Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038220 (status epilepticus)
 7,272 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Aphasia due to simple partial status epilepticus is rare, particularly in the absence of a seizure history. No previous report describes acute aphasia as the sole clinical manifestation of EEG-monitored status epilepticus, with prompt resolution with treatment. We report a 45-year-old man with a left temporal glioblastoma who acutely developed a global aphasia, during which an EEG revealed continual repetitive sharp waves emanating from the left hemisphere. After injection of i.v. diazepam, the EEG seizure activity ceased, and the patient's language output returned to preseizure levels.
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PMID:Aphasia as the sole manifestation of simple partial status epilepticus. 137 Aug 1

Partial status epilepticus rarely manifests mainly with global aphasia. It usually results in diffusion-weighted imaging (DWI) abnormalities after prolonged seizures. We discuss the magnetic resonance imaging (MRI) findings in a patient with aphasic status epilepticus. MRI showed diffusion restriction four hours after onset of symptoms. We summarize previously reported brain imaging findings in status epilepticus and discuss the purported mechanism behind these changes. Findings in our patient, similar to few others described in the literature, suggest that cortical DWI hyperintensities can occur shortly following aphasic status epilepticus.
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PMID:Early appearance of diffusion-weighted hyperintensities in aphasic status epilepticus. A case report. 2402 74

Nonconvulsive status epilepticus with neuropsychological symptoms other than aphasia or amnesia is rare. We report two such cases. Case 1, a 62-year-old man with a history of a subcortical hemorrhage in the right lateral temporal lobe and a brain infarct in the left medial temporo-occipital lobes, suddenly developed left unilateral spatial neglect and visual object agnosia. Diffusion-weighted imaging indicated status epilepticus, not stroke. His deficits resolved immediately after treatment with diazepam and phenytoin sodium. Case 2, a 61-year-old man with a history of brain infarcts in the right lateral temporal and left medial temporo-occipital lobes, suddenly developed global aphasia and cortical deafness. An MRI revealed no new lesions, including infarcts. An EEG revealed lateralized periodic discharges in the left temporo-parieto-occipital area, and single-photon emission computed tomography revealed a transient high-uptake lesion in the left temporoparietal lobes, indicating status epilepticus. His deficits also resolved immediately after treatment with diazepam and phenytoin sodium. The two patients' neuropsychological symptoms-visual object agnosia and cortical deafness-were associated with focal nonconvulsive status epilepticus and were successfully treated with anti-epileptic medications. It is suggested that individuals with acute neuropsychological symptoms be diagnosed with MRI and/or EEG as well as CT for differential diagnoses other than cerebrovascular diseases.
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PMID:Nonconvulsive Status Epilepticus With Neuropsychological Symptoms: Two Case Reports. 3326 55