Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0038220 (
status epilepticus
)
7,272
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Objective:
To measure mortality, identify predictors of death and investigate causes of death in patients with anti-gamma-aminobutyric-acid B receptor (anti-GABA
B
R) encephalitis.
Methods:
Prospective analysis of anti-GABA
B
R encephalitis cases diagnosed between June 2013 and August 2018 in West China Hospital of Sichuan University, with assessment of factors associated with mortality.
Results:
A total of 28 patients (11 females) with anti-GABA
B
R encephalitis were included in this study. After a maximum time of 52 months (median 11 months, range 2-52) of follow-up, 9 (32.1%) patients died, with a median survival time of 6.5 months. Five patients died of tumor progression, one patient died of convulsive
status epilepticus
, one patient died of septic shock, and two patients died of severe pneumonia. Predictors of death were older age at onset (
P
= 0.025), presence of a tumor (66.7 vs. 15.8%,
P
= 0.013), the number of complications (2.6 vs. 1.0,
P
= 0.009) and
deep venous thrombosis
(33.3% vs. 0,
P
= 0.026).
Conclusion:
Patients with GABA
B
R encephalitis have a high mortality rate within 5 years. Older age at onset, presence a tumor, the number of complications, and
deep venous thrombosis
are associated with death.
...
PMID:Encephalitis With Antibodies Against the GABA
B
Receptor: High Mortality and Risk Factors. 3168 Nov 35
