Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0038220 (status epilepticus)
 7,272 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 5-year-old Japanese male with intractable running and laughing fits was reported to have had status epilepticus from 18 hours after birth. This intractable convulsions were thought to be due to hyperviscosity syndrome induced by neonatal idiopathic polycythemia. A phlebotomy ended the convulsions in the neonatal period, but the EEG continued to display right temporal spikes afterwards. He suffered from running and laughing fits 3 to 5 times daily from the age of 2 years up to 4 years 8 months. EEG revealed generalized dysrhythmia and poly-spikes and waves, mainly in the right side. Computerized tomography showed dilatation of all the ventricles plus multiple low density areas in the right temporal lobe. This case of running and laughing fits was presumed to be one of the temporal lobe epilepsy induced by the hyperviscosity syndrome brought on by neonatal polycythemia.
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PMID:Running and laughing fits as the sequelae of the neonatal hyperviscosity syndrome. 55 52

A calcified epidural hydroma, or old hematoma, was incidentally found in the left parietal region of a 55-year-old man presenting status epilepticus due to uremia after a lapse of 16 years following head injury. The hydroma (10x7x1.2 cm) was extirpated operatirelly. There was an extensive calcificantion in the wall, and the outer wall showed bone-like metaplasia and hemosiderin deposit. No skull fracture was discernible. The dura and the brain surface neighboring the hydroma were gloslsly normal. The patient eventually died of uremia.
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PMID:[Calcified epidural hematoma-report of a case incidentally found 16 years after head injury (author's transl)]. 55 36

Three family members intoxicated with methyl bromide presented with a variety of neuropsychiatric manifestations including coma, severe status epilepticus, hyporeflexia, and acute psychosis. The simulation of Reye syndrome in the child emphasizes the need for careful toxicologic screening of all children presenting with this syndrome. The initial diagnostic difficulty encountered in these cases emphasizes the need for heightened awareness of the toxic chemicals used in local industries and the clinical manifestations of their intoxication.
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PMID:Methyl bromide intoxication: neurologic features, including simulation of Reye syndrome. 56 10

In the second trimester of pregnancy in a 26-year-old woman, marked exacerbation of epileptic seizures occurred with somatomotor status epilepticus. The oral requirement of phenytoin varied, and up to 1,200 mg per day were needed to maintain a therapeutic plasma concentration during the second trimester. Intestinal malabsorption was shown to be a causal factor; 56 percent of the daily oral dose of phenytoin was found in the stool. Late in pregnancy and postpartum, therapeutic plasma concentrations of phenytoin were maintained with decreased daily oral doses. Intestinal absorption improved postpartum.
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PMID:Status epilepticus in pregnancy: effect of phenytoin malabsorption on seizure control. 56 42

Acute renal failure developed in a 28-year-old man after status epilepticus. Myoglobinuria was contributed to by convulsions, trauma and coma during status epilepticus, the three mechanisms responsible for this condition.
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PMID:Myoglobinuria and renal failure after status epilepticus. 56 2

Four prolonged episodes of partial complex status epilepticus were observed in a teenaged girl. During each there was an "ictal" phase, in which her mental state frequently fluctuated between mildly clouded consciousness and almost total unresponsiveness; once, she was also blind during this phase of impaired consciousness. With therapy, the periods of unresponsiveness became less frequent and less prolonged until a second, "postictal," phase occurred when she was alert, but with profound retrograde and anterograde amnesia that gradually resolved in several weeks. The "ictal" EEG pattern always consisted of lateral temporo-occipital fast and sharp waves continually alternating with slow activity. These cycled independently in the two hemispheres and correlated with the fluctuating behavioral state. During the "postictal" phase the EEG was diffusely slow with isolated bilaterally independent temporal spikes. The key to the diagnosis of partial complex status epilepticus may be the fluctuating mental state. Recognition and prompt treatment of this disorder are important since delay could result in prolonged or enduring memory impairment.
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PMID:Prolonged partial complex status epilepticus: EEG and behavioral observations. 56 60

Large doses of phenytoin were administered on 159 occasions to 139 adult patients. Most patients had had more than three seizures or were in status epilepticus. Based on response to treatment, patients could be divided into two groups. Those with excellent response (recurrent seizures, 10%; mortality, 1%) included known epileptics with exacerbation of seizures (n = 75), atypical alcohol withdrawal (6), or miscellaneous conditions (17). Those with poor results (recurrent seizures, 57% mortality, 38%) included patients with anoxic or metabolic encephalopathy (14), stroke or other vascular disease (14), brain tumor (5), or trauma (5).
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PMID:Intravenous phenytoin in acute treatment of seizures. 57

Fifteen infants and children were treated with phenytoin for status epilepticus. They received doses 31.5 mg/kg (18--46) in the first 24 hours, 18.5 mg/kg (10--28) on the second day and 11 mg/kg (7.7--15.4) on the third day controlled by frequent serum level determinations. After reaching the upper therapeutic range (8--25 microgram/ml) within 24 hours these serum concentrations were maintained over the next days. Twelve of fifteen--including five newborns and infants below four months of age--were thus successfully treated; the remaining three in whom phenytoin had no effect, no other anticonvulsant drug or a combination of several other drugs were successful. A dose schedule based upon serial serum concentration measurements is given. It enables an efficient phenytoin treatment of status epilepticus or equivalent convulsive states in infancy and childhood.
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PMID:An effective dose schedule for phenytoin treatment of status epilepticus in infancy and childhood. 57 99

Disseminated intravascular coagulation is here reported as a complication of status epilepticus. Other features of this case were rhabdomyolysis, hyperthermia, myoglobinuria and renal failure.
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PMID:Disseminated intravascular coagulation in status epilepticus. 57 96

A 52 year old woman developed a severe encephalopathy with status epilepticus of six days duration in the terminal course of an acute hepatitis associated with hyperammonaemia and hyperventilation. Acute haemorrhagic lesions were observed in the brain, involving symmetrically both amygdala and cornu Ammonis. The sequential occurrence of these lesions with status epilepticus are discussed in the light of data from the literature.
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PMID:Mesial temporal haemorrhage, consequence of status epilepticus. 59 70


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