Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0038187 (starvation)
 24,951 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Calcium ions (Ca(2+)) and Ca(2+)-related proteins mediate a wide array of downstream processes involved in plant responses to abiotic stresses. In Arabidopsis (Arabidopsis thaliana), disruption of the vacuolar Ca(2+)/H(+) transporters CAX1 and CAX3 causes notable alterations in the shoot ionome, including phosphate (P(i)) content. In this study, we showed that the cax1/cax3 double mutant displays an elevated P(i) level in shoots as a result of increased P(i) uptake in a miR399/PHO2-independent signaling pathway. Microarray analysis of the cax1/cax3 mutant suggests the regulatory function of CAX1 and CAX3 in suppressing the expression of a subset of shoot P(i) starvation-responsive genes, including genes encoding the PHT1;4 P(i) transporter and two SPX domain-containing proteins, SPX1 and SPX3. Moreover, although the expression of several PHT1 genes and PHT1;1/2/3 proteins is not up-regulated in the root of cax1/cax3, results from reciprocal grafting experiments indicate that the cax1/cax3 scion is responsible for high P(i) accumulation in grafted plants and that the pht1;1 rootstock is sufficient to moderately repress such P(i) accumulation. Based on these findings, we propose that CAX1 and CAX3 mediate a shoot-derived signal that modulates the activity of the root P(i) transporter system, likely in part via posttranslational regulation of PHT1;1 P(i) transporters.
 ...
PMID:Vacuolar Ca2+/H+ transport activity is required for systemic phosphate homeostasis involving shoot-to-root signaling in Arabidopsis. 2154 57

The importance of SPX-domain-containing proteins to phosphate (Pi) homeostasis and signalling transduction has been established in plants. In this study, phylogenetic analysis revealed that OsSPX3 and OsSPX5 (SPX3/5) are paralogous SPX genes ( SYG1/Pho81/XPR1) in cereal crops. SPX3/5 are specifically responsive to Pi starvation at both the transcriptional and post-transcriptional levels. Similar tissue expression patterns of the two genes and proteins were identified by in situ hybridization and the transgenic plants harbouring SPX3pro-SPX3-GUS or SPX5pro-SPX5-GUS fusions, respectively. Both SPX3/5 are localized in the nucleus and cytoplasm in rice protoplasts and plants. SPX3/5 negatively regulate root-to-shoot Pi translocation with redundant function. The data showed that the Pi-starvation-accumulated SPX3/5 proteins are players in restoring phosphate balance following phosphate starvation. In vitro and in vivo protein-protein interaction analyses indicated that these two proteins can form homodimers and heterodimers, also implying their functional redundancy. Genetic interaction analysis indicated that SPX3/5 are functional repressors of OsPHR2 (PHR2), the rice orthologue of the central regulator AtPHR1 for Pi homeostasis and Pi signalling. These results suggest that the evolution of the additional redundant paralogous SPX genes is beneficial to plants recovering Pi homeostasis after Pi starvation by PHR2 pathway.
...
PMID:The paralogous SPX3 and SPX5 genes redundantly modulate Pi homeostasis in rice. 2436 4

Rapeseed (Brassica napus L.) is highly susceptible to boron (B) and phosphorus (P) deficiencies, yet knowledge of how these two essential elements interact to contribute to plant growth and crop yield is limited. To this end, a pot experiment with three P application rates (5, 75, and 150 mg P2O5 kg-1 dry soil) and two B application rates (0.25 and 1 mg B kg-1 dry soil) was conducted. The results showed that high P combined with high B optimized plant growth and facilitated P distribution forward to seeds compared with high P and low B combination at the maturity stage. Under low P conditions, low B supply was more beneficial for P absorption at seedling and bolting stages and increased P distribution ratio in seeds at the maturity stage, resulting in higher photosynthetic efficiency and growth parameters than low P and high B combination. Interestingly, high B supply could upregulate the expression of the P-starvation-induced gene BnaC3.SPX3 and P transport genes in roots under low P conditions, so low B-facilitated P absorption appears to be a BnaPHT1s-independent process. Significant differences of B and P interaction on the seed yield, net photosynthetic rate, and total P absorption and distribution at the maturity stage between two cultivars might reflect the distinct genotypic properties. Overall, our findings highlight the importance of balanced B and P nutrition which acts synergistically to modulate growth and yield formation of B. napus either in nutrition deficiency or sufficiency.
 ...
PMID:Boron and Phosphorus Act Synergistically to Modulate Absorption and Distribution of Phosphorus and Growth of Brassica napus. 3261 76