Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0038187 (
starvation
)
24,951
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Autophagy is a membrane trafficking process involved in intracellular degradation and recycling in eukaryotic cells.
DRAM2
(damage-regulated autophagy modulator 2) is a homologue of DRAM that regulates p53-mediated cell death. As its name implies, DRAM expression induces autophagy in a p53-dependent manner; however, the role of
DRAM2
in autophagy is not clear. In this study, we report that
DRAM2
expression contributes to autophagy induction. Overexpression of
DRAM2
induces cytoplasmic GFP-LC3 punctuates, and increases the level of endogenous LC3-II. Moreover, the silencing of endogenous
DRAM2
interferes with
starvation
-induced autophagy. Thus, we propose that
DRAM2
as well as DRAM are involved in autophagy.
...
PMID:The expression of damage-regulated autophagy modulator 2 (DRAM2) contributes to autophagy induction. 2158 98
