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Query: UMLS:C0038187 (starvation)
 24,951 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of mazindol (1 mg/day) on some metabolic and regulatory values was investigated in ten adult obese women and compared with the same number of controls during weight reduction in hospital (a five-times repeated cycle of 5 days complete starvation and 3 days on a 500 kcal(2.1MJ/day diet.) Mazindol caused a rise of hydroxyacyl CoA dehydrogenase in striated muscle by 70 per cent and a marked decline in malic dehydrogenase. Mazindol also produced higher levels of non-esterified fatty acids--significantly higher during the fifth starvation period; a small decrease in blood glucose, IRI and glucose/IRI ratio being unaffected, a significantly two-fold greater decrease of serum cholesterol; a significant increase of the noradrenaline elimination compared with a decrease in controls and in increase in triiodothyronine binding globulin towards the upper range of normal.
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PMID:The effect of mazindol on metabolic and regulatory changes in obese women during weight reduction. 9 88

Omental fat cells were 30% smaller than those in subcutaneous regions. In omental fat cells with a mean diameter of 95 mu, the basal cAMP concentration was 50% lower, but the basal rate of glycerol release was three times as rapid as in subcutaneous (epigastric) fat cells of identical size. Added at maximal effective concentration, noradrenaline increased the level of cAMP and the rate of glycerol release more markedly in the omental than in the subcutaneous adipocytes, whereas the response to isopropyl noradrenaline was similar. Before starvation the lipolytic effects of noradrenaline and isopropyl noradrenaline, respectively, were identical in the two regions of subcutaneous adipose tissue investigated (femoral and hypogastric). The findings were well related to the tissue levels of cAMP induced by the two agents. During starvation noradrenaline and isopropyl noradrenaline increased the cAMP level and the rate of lipolysis in fat cells obtained from the hypogastric region, whereas noradrenaline decreased these parameters in femoral adipocytes. Starvation was associated with a more prominent inhibitory effect of phenylephrine on basal and isopropyl-noradrenaline-induced lipolysis in femoral than in hypogastric adipose tissue. In conclusion, differences exist between different regions of adipose tissue in their lipolytic responsiveness to noradrenaline, which seems related to the balance between alpha- and beta-adrenergic receptor response.
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PMID:Regional differences in the control of lipolysis in human adipose tissue. 22 83

1. Intracranial or subcutaneous doses of atropine or atropine methyl nitrate that were fully effective at preventing drinking in response to intracranial carbachol did not block angiotensin-induced drinking. 2. The nicotinic antagonist dihydro-beta-erythroidine given intracranially affected neither angiotensin- nor carbachol-induced drinking. 3. The dopaminergic antagonists haloperidol and spiroperidol injected intracranially blocked angiotensin-induced drinking but did not affect carbachol-induced drinking. 4. Angiotensin- and carbachol-induced drinking were unaffected by alpha- or beta-adrenergic antagonists except at toxic doses. 5. Destruction of catecholaminergic neurones with 6-hydroxydopamine markedly reduced angiotensin-induced drinking, but had relatively little effect on carbachol-induced drinking. 6. Intracranial haloperidol reduced the amount of water drunk in response to overnight deprivation of water, but did not affect feeding in response to overnight starvation or to intracranial noradrenaline. 7. Drinking following overnight water deprivation was unaffected by intracranial alpha- or beta-adrenergic antagonists. 8. Preventing dopaminergic transmission with intracranial haloperidol decreased the water to food ratio of the rat's intake after overnight starvation, whereas increasing the dopamine levels with the combination of FLA-63 and L-DOPA increased the ratio. 9. Intraventricular dopamine in large amounts caused the water-replete rat to drink. 10. It is concluded that among the many functions of dopaminergic systems in the brain is a role in the control of water intake, and that these systems participate in an important way in drinking in response to angiotensin.
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PMID:The relative importance of central nervous catecholaminergic and cholinergic mechanisms in drinking in response to antiotensin and other thirst stimuli. 24 Sep 34

Teh effect of 48 hr food deprivation on noradrenaline (NA) and dopamine (DA) content in the dorsomedial, ventromedial and arcuate hypothalamic nuclei, in the anterior and posterior part of medial forebrain bundle, in the medial preoptic region, nucleus of diagonal band (septum), and in the central, medial and basal nuclei of the amygdaloid complex was investigated by radioenzymatic assay. It was found that starvation resulted in decreased NA and DA levels in arcuate and ventromedial nuclei, and increased DA content in the posterior medial forebrain bundle. A statistically insignificant increase of DA in the central amygdaloid nucl. was also observed.
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PMID:Hunger induced changes in the noradrenaline and dopamine contents in various nuclei of the limbic system in rats. 31 24

A highly sensitive double isotope method for the simultaneous determination of serotonin, dopamine, noradrenaline and adrenaline has been developed. Advantages and limitations of the method are discussed. The mentioned biogenic amines are all present in isolated pancreatic islet tissue from albino mice in concentrations ranging from approximately 5-30 micronmol per kg wet weight (0.8-5 X 10(-3) pmol/ng DNA). A somewhat higher content of these amines, especially dopamine, was found in pancreatic acinar tissue. The hypothesis that the impaired glucose-induced insulin secretion during starvation partly is caused by an increased content of biogenic amines in the pancreatic islets was not supported by our experiments which showed an unchanged islet content of these amines after 48 h starvation.
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PMID:Simultaneous determination of the content of serotonin, dopamine, noradrenaline and adrenaline in pancreatic islets isolated from fed and starved mice. 33 61

Experiments show the influence of progressive starvation upon the synthetic and metabolic activity of monoaminergic function in the brain and the adrenal gland of young rats of two different ages. Brain and adrenal monoamine oxidase (MAO) showed a tendency to decline with the prolongation of the starvation interval. After 60 h of starvation, MAO activity was irreversibly decreased, even with 24 h of feeding, in the two age groups. Cerebral catechol-O-methyltransferase (COMT) activity was very slightly affected in response to the starvation in the older group, but the younger group showed an increased level of enzyme activity, and refeeding after 60 h of starvation of the young rats produced further increases. 60 h of starvation produced an increase in COMT activity of the adrenal gland of the older rats whereas the younger group did not show any marked change. Adrenal phenylethanolamine-N-methyltransferase (PNMT) declined after 24 and 48 h of starvation in the older rats, but the younger rats showed progressive increases after similar intervals of starvation. After 60 h of starvation, PNMT in the adrenal gland of the old rats increased significantly when compared to the control value, but the younger rats did not show any important change. Adrenal stores of adrenaline rose progressively up to 60 h of starvation in the old rats whereas the younger group responded in a contrary manner. Adrenal noradrenaline followed a similar pattern of evolution in both groups up to 60 h of starvation (when the results are expressed per milligram of adrenal protein), and refeeding had very little influence on the effects of starvation. The effects of starvation upon adrenal and cerebral MAO activity were verified with two different substrates. The results provide evidence that the metabolism of monoamines by oxidative deamination can be markedly affected by starvation, and this can be irreversible even after 24 h of feeding of starved rats. COMT activity augments when MAO activity declines.
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PMID:Influence of progressive starvation upon brain and adrenal monoaminergic activity in developing rats of two different ages. 47 96

Monoamine oxidase (MAO) activity was studied in whole brain, hypothalamus, adrenals and liver of developing rats subjected to disturbed feeding patterns or undernutrition for 3 weeks. The rats were divided into six groups: (1) normally fed controls; (2) rats starved for 24 h, fed for the following 8 h and killed after the last starvation period (PAS); (3) same treatment as in (2) but killed after the last feeding period (PAF); (4) rats starved for 16 h, fed for the following 8 h at a constant schedule, and killed after the last starvation period (PS); (5) same treatment as in (4) but killed after the last feeding period (PF), and (6) undernourished (U). Alteration of the feeding time resulted in significant decreases of MAO activity in the brain and the adrenal gland whereas the hypothalamus and the liver showed a slight increase in activity in the PAS group. In PS rats, MAO activity increased in the brain, adrenals and hypothalamus; in PF rats, the effects of the treatment were inverse. Both in the PS and PF rats, hepatic MAO activity was strongly decreased when assayed with kynuramine. In U rats, hepatic MAO activity was highly increased when assayed with kynuramine but the other tissues responded differently. The adrenaline and noradrenaline stocks of the adrenal gland were markedly increased in all the treated groups; the maximum increase in noradrenaline was observed in the PS rats. The results suggest that any disturbance in the feeding pattern affects the MAO activity in the central and peripheral regions of the young rat during postnatal development. The developing rat seems to get accustomed to new alimentary rhythms, and normal monoaminergic function is rapidly restored when the rat is given a compensatory diet. Increased adrenal catecholamines after a disturbance in the feeding patterns seem to be a response to stress.
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PMID:Maintenance of central and peripheral monoamine oxidase activity in developing rats subjected to disturbed alimentary rhythms and undernutrition. 47 1

The effect of intragastric glucose infusion (1.5 g per rat) to sated rats on the catecholamine content in the medial basal and lateral hypothalamic regions and in the nuclei of the amygdaloid body was investigated. The effect of glucose overloading on the noradrenaline (NA) and dopamine (DA) content in the ventromedial (VMH) and arcuate hypothalamic nuclei was also studied in rats deprived of food for 48 hr. Glucose administration to rats fed ad lib. resulted in an increase in NA in the VMH and a decrease in DA in the central nucleus of the amygdaloid body. In fasted animals glucose overloading partially reversed the changes of NA concentration in the arcuate nucleus produced by starvation, whereas in the VMH glucose was not effective in producing any changes of catecholamine content. Possible interrelations between the amygdala and hypothalamus in respect to the role of catecholamines in the regulation of food intake are discussed.
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PMID:The relationship between catecholamine levels in the hypothalamus and amygdala under influence of glucose overloading in hungry and sated rats. 52 39

The recovery of brain noradrenaline (NA) from a single dose of 100 mg/kg pyrazole was rapid, but after 500 mg/kg brain NA levels were still maximally reduced 3 days later and did not return to normal until 7 days after injection. The consumption of water followed a similar time course at this dose. Sub-acute experiments were carried out in two sets of animals: those with free access to food and water throughout the experiment and those which during the latter half of the experiment received a known, restricted quantity of food and fluid by gastric intubation. Diet restriction did not alter the pyrazole induced decrease in brain NA and potentiated the decrease observed in the heart. A significant increase in brain 5-hydroxyindoleacetic acid was observed with pyrazole 100 mg/kg in both diet schedules. In addition to the disturbances in food and water consumption, pyrazole also caused a decrease in locomotor activity which was only partly due to the starvation. Rectal temperature did not change. At the higher pyrazole dose in the rats fed by intubation there was incomplete emptying of the stomach. It is concluded that these many changes demonstrate the non-specificity of pyrazole and caution is advocated in its use combined with ethanol in research on experimental alcoholism.
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PMID:Effects of pyrazole treatment of physical status and brain biogenic amines in rats. 86 52

1. The regulation of the synthesis of phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) in epididymal adipose tissue, liver and kidney in vivo was studied immunochemically. 2. Phosphoenolpyruvate carboxykinase (GTP) synthesis in adipose tissue is increased by starvation, diabetes and noradrenaline, and decreased by re-feeding and insulin. These changes were also seen in adrenalectomized rats and are qualitatively similar to those observed for the liver enzyme. This indicates the involvement of cyclic AMP as an inducer and insulin as a de-inducer in the regulation of phosphoenolpyruvate carboxykinase (GTP) in both tissues. (Induction and de-induction are defined as selective increase and decrease respectively in the rate of enzyme synthesis, regardless of the mechanism involved.)3. Adrenalectomy had little effect on phosphoenolpyruvate carboxykinase (GTP) synthesis in liver and kidney, but increased the synthesis rate of the adipose-tissue enzyme. Starvation and adrenalectomy had additive effects in increasing the synthesis rate of adipose-tissue phosphoenolpyruvate carboxykinase (GTP). In adrenalectomized diabetic rats glucocorticoids increased phosphoenolpyruvate carboxykinase (GTP) synthesis in liver and kidney while decreasing enzyme synthesis in adipose tissue. De-induction of adipose tissue phosphoenolpyruvate carboxykinase (GTP) is therefore regulated independently by glucocorticoids and insulin. 4. Although liver, kidney and adipose-tissue phosphoenolpyruvate carboxykinases (GTP) are seemingly identical, there is an apparent tissue-specific differentiation in regulatory systems for the enzyme.
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PMID:Regulation of phosphoenolpyruvate carboxykinase (GTP) in adipose tissue in vivo by glucocorticoids and insulin. 96 85


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