Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Enzyme
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Query: UMLS:C0038187 (
starvation
)
24,951
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The gastrodermis of adult Schistosoma mansoni was examined by electron microscopy to determine the effects of
starvation
and the effects of hycanthone, administered in vitro. Special attention was focused on the relationship of the Golgi complexes with the process of autophagy. In general, autophagy was increased in the gastrodermis when it was exposed to stress conditions such as
starvation
and hycanthone. Acid phosphatase and thiamine pyrophosphatase activities were used as enzyme markers for the Golgi complexes and lysosomes. During the early stages of
starvation
, there was a 4-fold increase in the number of Golgi complexes per unit area in the gastrodermis. A progressive increase in the number of secondary lysosomes was evident as
starvation
time was increased.
Hycanthone
accelerated the effects of
starvation
. It was hypothesized that acid hydrolases are passed to the Golgi complexes via ER-derived vesicles. The enzymes are subsequently released as primary lysosomes from the Golgi complex to fuse with cytosegresomes and form secondary lysosomes (cytosomes).
...
PMID:Cytochemistry of gastrodermal autophagy following starvation in Schistosoma mansoni. 112 52
