Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038187 (starvation)
 24,951 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A sudden induction of the imbalance between the rates of DNA and protein synthesis in the cell (by nalidixic acid or by thymine starvation) results in the stabilization of breaks in DNA chains in vivo. Such "imbalance induced breaks" represent gaps in DNA chains formed with the participation of exonuclease V. Stabilization of the "imbalance induced breaks" is accompanied by DNA degradation and cell death. Restoration of the imbalance between the rates of DNA and protein syntheses by balanced inhibition completely prevents the stabilization of breaks in cells with competent repair systems. Balanced inhibition of intracellular DNA and protein synthesis decreases the rate of repair and permits to see the sequence of induction (stabilization) and disappearance (repair) of breaks in DNA chains in vivo. Repair of breaks occuring on the background of balanced inhition of DNA and protein synthesis decreases the extent of DNA degradation and completely prevents death of E. coli cells with completely functional repair systems.
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PMID:[Induction and repair of breaks in DNA chains in vivo due to the imbalance between DNA and protein synthesis]. 37 3

The phenomenon of metabolic mutagenesis is found to be determined by stabilization of metabolic breaks in DNA chains, being linked with disbalance of intracellular synthesis of DNA and protein. The rate of metabolic mutagenesis observed in case of the DNA-protein synthesis disbalance due to thymine starvation is influenced by cell genotype. The lack of exonuclease V in recB-thy- cells decreases (reduces) the rate of metabolic mutagenesis and does not effect the viability. The lack of DNA polymerase I activity in polA-thy- cells causes a sharp increase in the metabolic mutagenesis rate and a parallel sharp drop in the survival under thymine starvation, as compared to cells with polA+thy- genotype.
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PMID:[Relation between Escherichia coli K-12 viability and mutability and the balance between DNA and protein synthesis. III. Relation between disruptions in the balance between DNA and protein synthesis and mutagenesis and viability during thymidine deprivation of thy- cells defective with respect to recB and polA genes]. 625 61

Investigation of the formation of metabolic imbalance breaks in the DNA of thy- cells of E. coli during thymine starvation is described. The results of experiments indicate that two enzymes--exonuclease V and 3' exonuclease activity of DNA polymerase II take part in the formation of metabolic imbalance gaps. The manifestation of activity of the enzymes has a tandem character.
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PMID:[Molecular mechanisms of stabilization and preparation of metabolic breaks in DNA strands in vivo. I. Tandem action of exonuclease V and DNA polymerase II]. 628 32