Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038187 (starvation)
 24,951 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. The activities of four enzymes of glycolysis were assayed in the liver of five different strains of rats (four ;Wistar-derived', one Sprague-Dawley) kept on three different but very similar diets. 2. Major strain differences were found for the activities of pyruvate kinase (3-fold), alpha-glycerophosphate dehydrogenase (5-fold), glyceraldehyde phosphate dehydrogenase (3-fold) and triokinase (1.5-fold). 3. Although the initial activities of pyruvate kinase differed greatly the percentage responses to starvation or a diet high in soluble carbohydrate were of the same order in two strains. 4. The importance of considering strain differences is emphasized when making comparisons of measurements carried out in different laboratories.
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PMID:Strain differences in the activities of rat liver enzymes. 534 4

We have examined the role of fructose as a substrate for the mammalian lung. Isolated and ventilated rat lungs were perfused for 2 h in the presence of either [U-14C]- or [5-3H]fructose. Fructose utilization, 3H2O production, and lactate and pyruvate production were measured. Insulin had no effect on the production of radiolabeled lactate. The 14C label from [U-14C]fructose was incorporated into the neutral lipids, phospholipids, fatty acid moiety, and deacylated fraction of lung. The apparent Km and maximum velocity of enzyme reaction for fructose utilization were 0.5 mM and 75 nmol X h-1 X g dry wt-1, respectively. Recovery of fructose 1-phosphate and fructose 1,6-diphosphate after perfusion with fructose, as well as detection of fructokinase, aldolase, and triokinase activities in the lung homogenates, suggested that fructose had been metabolized via phosphorylation through fructose 1-phosphate. Activities of fructose-metabolizing enzymes were not altered by the induction of diabetes, hypophysectomy, or starvation. These results suggest that mammalian lungs may utilize fructose to synthesize fatty acids, which in turn are used for phospholipid biosynthesis. The utilization of fructose by lung does not seem to be affected by nutritional or hormonal conditions.
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PMID:Fructose utilization by lung. 632 66