Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0038187 (
starvation
)
24,951
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
When carrot suspension cells were cultured on medium containing no carbon source (
starvation
), the levels of phosphatidylserine (PS) increased transiently 3-4 d after the initiation of
starvation
while levels of most other phospholipid (PL) species decreased. We previously reported that fatty acids of these PLs served as an alternative carbon source during
starvation
. The present study showed that cells possess two different biosynthetic pathways involving phosphatidylcholine (PC)/phosphatidylethanolamine (PE) exchange enzymes and PS synthase to synthesize PS. These activities peaked similarly 4 d after the initiation of
starvation
and coincided with the peak of PS level. The synthesis of serine was also significantly activated during
starvation
. The activity of
phosphoserine aminotransferase
(
PSAT
) which is involved in serine synthesis increased with a time course similar to that of the increase in the PS level. These observations suggest that the increase in PS level plays an important role in membranes which are degraded during
starvation
.
...
PMID:Synthesis of phosphatidylserine in carrot cells cultured under carbon-source starvation. 1114 73
