Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038187 (starvation)
 24,951 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Prednisolone (2 mg/kg) was injected daily for 14 days. Collagen and protein biosynthesis were measured in isolated molar and incisor pulps by the incorporation of [14C]-proline into protein and collagen in vitro. Collagen solubility, free proline content, prolyl hydroxylase activity, collagenolytic activity and DNA and RNA contents were also assayed. Rabbits injected with saline or starved served as controls. Collagen synthesis was inhibited selectively in both prednisolone and starvation groups. No other aspect of collagen and protein metabolism was affected by either prednisolone treatment or starvation. Thus glucocorticoid administration reduces collagen formation in the pulp, resembling the anti-anabolic effect of starvation. Glucocorticoid treatment at high daily dosages, therefore, may disturb normal development and metabolism of teeth.
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PMID:Selective inhibition of collagen biosynthesis in the dental pulps of glucocorticoid-treated rabbits. 619 Apr 70

Broiler chicks, 4 weeks of age, were subjected to a regimen of 48-hr starvation and 24-hr refeeding as a means of inducing hepatic glycogen supercompensation. A synthetic glucocorticoid (prednisolone) and transcription inhibitor (actinomycin D) treatment were superimposed on the starvation-refeeding regimen to examine the effect of an exogenous glucocorticoid and the necessity for de novo protein synthesis during glycogen supercompensation. Starvation decreased plasma glucose, immunoreactive insulin and liver glycogen. These parameters returned to, or overshot prefasting levels after a 48-hr refeeding period. Prednisolone magnified the overshoot response but some de novo protein synthesis was required. Glycogen synthase a activity was opposite that of liver glycogen content. A possible nonhormone stimulated glycogen synthetic mechanism in the starvation-refeeding response of the chick was noted.
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PMID:Effect of starvation-refeeding and an exogenous glucocorticoid on carbohydrate metabolism in chick liver. 644 19