Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0038187 (
starvation
)
24,951
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The cylindromatosis (
CYLD
) gene is mutated in human tumors of skin appendages. It encodes a deubiquitylating enzyme (
CYLD
) that is a negative regulator of the NF-kappaB and JNK signaling pathways, in vitro. However, the tissue-specific function and regulation of
CYLD
in vivo are poorly understood. We established a genetically tractable animal model to initiate a systematic investigation of these issues by characterizing an ortholog of
CYLD
in Drosophila. Drosophila
CYLD
is broadly expressed during development and, in adult animals, is localized in the fat body, ovaries, testes, digestive tract and specific areas of the nervous system. We demonstrate that the protein product of Drosophila
CYLD
(
CYLD
), like its mammalian counterpart, is a deubiquitylating enzyme. Impairment of
CYLD
expression is associated with altered fat body morphology in adult flies, increased triglyceride levels and increased survival under
starvation
conditions. Furthermore, flies with compromised
CYLD
expression exhibited reduced resistance to bacterial infections. All mutant phenotypes described were reversible upon conditional expression of
CYLD
transgenes. Our results implicate
CYLD
in a broad range of functions associated with fat homeostasis and host defence in Drosophila.
...
PMID:A Drosophila ortholog of the human cylindromatosis tumor suppressor gene regulates triglyceride content and antibacterial defense. 1755 7
