Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038187 (starvation)
 24,951 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Phosphate is essential for cell metabolism in all organisms. As it is often limiting in the soil, plants have evolved various mechanisms to cope with low-phosphate conditions. Here, we report that Aluminum Sensitive 3 and NAP3, two genes previously identified to function in aluminum tolerance, play a critical role in plant response to phosphate deficiency. Two T-DNA insertional alleles of ALS3 gene in Arabidopsis showed hypersensitive responses to phosphate limiting conditions. Compared to the wild type, als3 mutant plants exhibited more severe root growth inhibition and developed more root hairs under phosphate starvation. Interestingly, these phenotypic changes occurred only when the low-phosphate medium is supplemented with sucrose, suggesting that ALS3 regulates low-phosphate response in a sugar-dependent manner. Furthermore, NAP3, a gene encoding the nucleotide binding domain protein that physically interacts with ALS3, was implicated in the same pathway in response to low-P. The nap3 mutant showed the same phenotype as the als3 mutant when grown on phosphate depletion medium. We conclude that ALS3 and NAP3 protein form an ABC transporter complex that is required for sugar-dependent response to phosphate deficiency.
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PMID:An ABC transporter complex encoded by Aluminum Sensitive 3 and NAP3 is required for phosphate deficiency responses in Arabidopsis. 2598 20

Antimicrobial peptides and proteins play critical roles in the host defense against invading pathogens. We recently discovered that recombinantly expressed human and mouse serum amyloid A1 (rhSAA1 and rmSAA1, respectively) proteins have potent antifungal activities against the major human fungal pathogen Candida albicans At high concentrations, rhSAA1 disrupts C. albicans membrane integrity and induces rapid fungal cell death. In the present study, we find that rhSAA1 promotes cell aggregation and targets the C. albicans cell wall adhesin Als3. Inactivation of ALS3 in C. albicans leads to a striking decrease in cell aggregation and cell death upon rhSAA1 treatment, suggesting that Als3 plays a critical role in SAA1 sensing. We further demonstrate that deletion of the transcriptional regulators controlling the expression of ALS3, such as AHR1, BCR1, and EFG1, in C. albicans results in similar effects to that of the als3/als3 mutant upon rhSAA1 treatment. Global gene expression profiling indicates that rhSAA1 has a discernible impact on the expression of cell wall- and metabolism-related genes, suggesting that rhSAA1 treatment could lead to a nutrient starvation effect on C. albicans cells.
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PMID:The Als3 Cell Wall Adhesin Plays a Critical Role in Human Serum Amyloid A1-Induced Cell Death and Aggregation in Candida albicans. 3220 53