Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0038187 (
starvation
)
24,951
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The pocket protein family controls several cellular functions such as cell cycle, differentiation, and apoptosis, among others; however, its role in stress has been poorly explored. The roundworm Caenorhabditis elegans is a simple model organism whose genes are highly conserved during evolution. C. elegans has only one pocket protein, LIN-35; a pRB-related protein similar to p130. To control the expression of some of its targets, LIN-35 interacts with E2F-DP transcription factors and LIN-52, a member of SynMUV (Synthetic Muv complex). Together, these proteins form the
DRM
complex, which is also known as the DREAM complex in mammals. In this review, we will focus on the role of LIN-35 and its partners in the stress response. It has been shown that LIN-35 is required to control
starvation
in L1 and L4 larval stages, and to induce
starvation
-induced germ apoptosis. Remarkably, during L1
starvation
, insulin/IGF-1 receptor signaling (IIS), as well as the pathogenic, toxin, and oxidative stress-responsive genes, are repressed by LIN-35. The lack of lin-35 also triggers a downregulation of oxidative stress genes. Recent works showed that lin-35 and hpl-2 mutant animals showed enhanced resistance to UPR
ER
. Additionally, hpl-2 mutant animals also exhibited the upregulation of autophagic genes, suggesting that the SynMuv/
DRM
proteins participate in this process. Finally, lin-35(n745) mutant animals overexpressed hsp-6, a chaperone that participated in the UPR
mt
. All of these data demonstrate that LIN-35 and its partners play an important role during the stress response.
...
PMID:LIN-35 beyond its classical roles: its function in the stress response. 3293 Mar 65
