Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0038187 (
starvation
)
24,951
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Two forms of acetyl-CoA synthetase (
ACS1
and ACS2) have been detected in Phycomyces blakesleeanus.
ACS1
, encoded by the gene facA, was induced by acetate and repressed by glucose at the transcriptional level. ACS2, not encoded by the gene facA, was detected as a response to carbon
starvation
both in the wild type and in an facA(-) mutant. Both enzymes were purified and characterized. They can use acetate and propionate as substrates. ACS2 is a much more stable enzyme than
ACS1
. After 60 min incubation at 55 degrees C, ACS2 retained 50% of its activity whereas
ACS1
only retained 3%. The optimum temperature was 50 degrees C for ACS2 and 30 degrees C for
ACS1
.
...
PMID:An acetyl-CoA synthetase not encoded by the facA gene is expressed under carbon starvation in Phycomyces blakesleeanus. 1592 92
