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Query: UMLS:C0038187 (starvation)
 24,951 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Pathological studies on the internal organs, endocrine glands inclusive, are carried out in white rats under conditions of deficient alimentation and fasting. The results of the study show that complete starvation with preceding full value or restricted (2 hours daily) feeding brings about a variety of morphological reactions in the internal organs and endocrine glands. The liver proves to be the most sensitive to reduced food supply it shows a marked response with fatty dystrophy and subsequent atrophy. Next ranks the kidney. Myocardium, spleen, thyroid gland, adrenals and testes fall in the third group--with a weaker and rather delayed response. Small intestine, lung and hypophysis do not show changes worth noting. The investigations performed are related to the effect exerted by starvation and deficient nutrition, assumed as a stress factor for the organism.
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PMID:[Morphological changes in the internal organs and endocrine glands of rats subjected to deficient nutrition and fasting]. 123 99

Maintenance of gut mucosal homeostasis depends on a balance between cell proliferation and cell death. Gut mucosal integrity is impaired after severe burn and during starvation. We determined the effect of burn, starvation, and the combination of both on small bowel epithelial apoptosis and proliferation. Fifty adult male Fischer 344 rats (260-300 g) received a 60% full-thickness scald burn and were randomly divided into fed and starved groups. Small intestine was taken at 12, 24, and 48 hr after injury. All animals in the 12-hr group were starved while recovering from anesthesia. Apoptosis was quantified by immunohistochemical staining (TUNEL) and mucosal proliferation was determined by bromodeoxyuridine (BrdU) incorporation. The apoptotic index was higher in burned rats compared to controls at 12 hr after burn; both these groups were starved (P < 0.05). At 24 and 48 hr after burn, apoptosis was highest in the starved groups, with no additional effects of burn (P < 0.05). Mucosal epithelial cell proliferation was not different between groups at any time point. In conclusion, burn and starvation both increase apoptosis in the small bowel mucosa; however, these effects are not additive. Apoptosis could be attenuated by enteral feeding, which delineates the importance of early enteral feeding initiation after injury to maintain mucosal integrity.
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PMID:Burn and starvation increase programmed cell death in small bowel epithelial cells. 1071 61