Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
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Target Concepts:
Gene/Protein
Disease
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Query: UMLS:C0038187 (
starvation
)
24,951
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Alcoholic liver disease
(
ALD
) is one of the major causes of chronic liver disease worldwide. Currently, no successful treatments are available for
ALD
. The pathogenesis of
ALD
is characterized as simple steatosis, fibrosis, cirrhosis, alcoholic hepatitis (AH), and eventually hepatocellular carcinoma (HCC). Autophagy is a highly conserved intracellular catabolic process, which aims at recycling cellular components and removing damaged organelles in response to
starvation
and stresses. Therefore, autophagy is considered as an important cellular adaptive and survival mechanism under various pathophysiological conditions. Recent studies from our lab and others suggest that chronic alcohol consumption may impair autophagy and contribute to the pathogenesis of
ALD
. In this chapter, we summarize recent progress on the role and mechanisms of autophagy in the development of
ALD
. Understanding the roles of autophagy in
ALD
may offer novel therapeutic avenues against
ALD
by targeting these pathways.
...
PMID:Role and mechanisms of autophagy in alcohol-induced liver injury. 3130 84
