Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0038002 (splenomegaly)
 9,873 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

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Human Gene/Protein
IL12RB1 protein 11.7
Smith-Magenis syndrome chromosome region, candidate 8 11.7
sterolin 2 11.7
mitogen-activated protein kinase associated protein 1 10.7
MYC binding protein 2 10.7
neurobeachin-like 2 10.5
solute carrier family 15, member 4 10.1
FKSG76 10.1
WD repeat domain 41 10.1
SCLL 9.7
C7orf11 9.7
TNF receptor-associated factor 5 9.7
uroporphyrinogen-III synthase 9.3
FCRN 9.3
CA X 9.3
SMCR8 9.1
MUNC18-2 9.1
RAB15 9.1
MFSD1 9.1
DRF1 9.1
WDR41 9.0
NBEAL2 8.7
TOM1L2 8.7
NOTCH2 protein 8.7
FIP1L1/PDGFRA fusion 8.7
STX5 8.7
MHCS 8.7
CD37 antigen 8.5
Phospholipase D4 8.5
HCL3 8.5
Transcobalamin I 8.3
FNTB 8.3
SLAM-associated protein 8.3
TALDO1 8.3
SPTB 8.3
Asrij 8.3
CSRP1 8.2
SEC23B 8.1
sulfatase modifying factor 1 8.1
TTDN1 8.1
TOM1L1 8.1
RCAN2 8.1
EPB42 8.0
IGVH 8.0
VH4-34 7.9
ANK1 7.9
phospholipase D3 7.8
sterolin 7.7
MTCP-1 7.7
Fc gamma receptor IIB 7.7
Niemann-Pick disease, type C1 7.7
Munc13-4 7.7
MAPKAP1 7.7
ccr6 7.7
Natural resistance-associated macrophage protein 1 7.7
ZNF202 7.7
immunoglobulin M heavy chain 7.7
imiglucerase 7.6
BCR/ABL protein 7.5
TNFRSF6 7.5
alpha 1 globin 7.5
GPR116 7.5
ATG16L 7.4
STX6 7.4
CD11d 7.4
ABIN-3 7.4
PLA2G3 7.4
MPL 7.4
ELTD1 7.3
BCR/ABL1 fusion 7.3
KAISO 7.3
hPHT1 7.3
Calreticulin 7.2
HLA B44 7.2
differentially expressed in normal and neoplastic cells 7.1
PSTPIP2 7.1
WASP interacting protein 7.1
C-X-C chemokine receptor type 5 7.1
JAK2 7.1
CPA4 7.1
more...
Disease
staphylitis 11.7
Adenomegaly 11.7
Rheumatic myocarditis 11.7
panhemocytopenia 11.7
Papovavirus infection 11.7
Neorickettsiosis 11.7
nonautoimmune hemolytic anemia 11.7
anemia; progressive 11.7
Fleisher ring 10.7
Disseminated protothecosis 10.7
Splenic sequestration 10.7
Turkey hemorrhagic enteritis 10.7
Rietti-Greppi-Micheli 10.7
Secondary autoimmune haemolytic anaemia 10.7
XLTT 10.7
Polycystic hydatid 10.7
Myelemia 10.7
Splenic lymphoma 10.3
Hairy cell leukemia variant 10.3
Beta thalassemia intermedia 10.1
Banti 10.1
splenoptosis 10.1
Hepatic schistosomiasis 10.1
Mediterranean macrothrombocytopenia 10.1
Adenylate kinase deficiency 10.1
Hematocytopenia 10.1
Myeloid hyperplasia 10.1
Storage pool deficiency 10.1
Littoral cell angioma 10.0
Hepatosplenic schistosomiasis 10.0
hypersplenism 9.9
Splenic marginal zone lymphoma 9.7
Splenic cyst 9.7
Megakaryocytic hyperplasia 9.7
Quail bronchitis 9.7
Endomyocardial disease 9.7
Sea-blue histiocytosis 9.7
PPBL 9.7
Calabar swelling 9.7
Granulomatous uveitis 9.7
B-cell prolymphocytic leukemia 9.6
leukoerythroblastosis 9.5
Felty's syndrome 9.5
Acute myelofibrosis 9.5
splenic disease 9.5
Prolidase deficiency 9.5
splenic marginal zone lymphoma 9.4
Sickle cell thalassemia 9.3
Epstein-Barr viremia 9.3
Massive hematemesis 9.3
Coombs negative hemolytic anemia 9.3
Persistent lymphocytosis 9.3
Myelomonocytic leukemia 9.3
Acute orchitis 9.3
Splenic necrosis 9.3
Abdominal lymphadenopathy 9.2
Splenic hamartoma 9.2
Marble spleen disease 9.1
refractory hairy cell leukemia 9.1
Cavernous lymphangioma 9.1
Myeloid metaplasia 9.1
Recurrent urticaria 9.1
Acute idiopathic thrombocytopenic purpura 9.1
perisplenitis 8.9
autoimmune lymphoproliferative syndrome 8.9
Granulocytosis 8.8
untreated hairy cell leukemia 8.8
Congenital thrombocytopenia 8.8
nutmeg liver 8.8
Spontaneous rupture of spleen 8.8
Myeloproliferation 8.8
Wandering spleen 8.8
Hepatosplenic T-cell lymphoma 8.8
Congenital malaria 8.8
Congenital hepatic fibrosis 8.7
Cruveilhier-Baumgarten syndrome 8.7
myelofibrosis 8.7
chronic neutrophilic leukemia 8.7
primary myelofibrosis 8.7
splenic infarction 8.7
more...
Symptom
splenomegaly 11.7
Venous hum 10.7
Bronchial breathing 9.7
hepatomegaly 9.4
left upper quadrant pain 8.9
enanthema 8.5
Kehr's sign 8.3
Easy bruising 8.2
pallor 7.5
Kayser-Fleischer ring 7.4
night sweats 7.2
hepatosplenomegaly 7.1
Scrotal pain 7.1
Osler's nodes 7.0
Multiple symptoms 6.8
Sore 6.8
periorbital edema 6.7
fever of unknown origin 6.7
generalized abdominal pain 6.6
Roth spots 6.4
dark urine 6.3
emaciation 6.1
abdominal discomfort 6.1
Physical findings 6.1
epigastric distress 6.1
Kernig's sign 6.0
Reticulocytosis 6.0
prostration 5.9
pedal edema 5.9
Flu-like symptoms 5.8
Chronic abdominal pain 5.8
abdominal fullness 5.8
General symptoms 5.8
clubbing 5.8
Murphy's sign 5.7
lethargy 5.7
Organ failure 5.7
bone pain 5.7
decreased appetite 5.6
non-productive cough 5.5
lassitude 5.5
sore throat 5.4
asthenia 5.4
Neurologic symptoms 5.1
abdominal pain 5.1
generalized pain 5.0
NVE 5.0
arthralgia 5.0
intestinal bleeding 5.0
anorexia 5.0
chills 5.0
monoplegia 4.9
Visual disturbances 4.8
hypoproteinemia 4.8
epigastric pain 4.8
rigors 4.6
cachexia 4.5
chromosome marker 4.5
livedo 4.5
generalized rash 4.5
Ill 4.5
myalgia 4.4
tachypnea 4.4
Respiratory symptoms 4.4
menometrorrhagia 4.4
exertional chest pain 4.3
acute abdominal pain 4.3
right upper quadrant pain 4.2
scaly skin 4.2
abdominal cramps 4.2
adenitis 4.1
catarrh 4.1
impaired motor coordination 4.1
giddiness 4.0
giddiness 4.0
acute abdomen 4.0
consciousness disturbance 4.0
labored breathing 3.9
productive cough 3.8
oliguria 3.8
more...
Drug
Ceredase 8.1
Cerezyme 8.0
Cerezyme 7.9
Mebrofenin 7.5
Roferon A 7.3
Nipent 7.3
Halofantrine hydrochloride 7.2
Histoplasmin 7.1
Lumefantrine 6.7
Thioguanine 6.6
Miglustat 6.6
Glucantime 6.4
Plaquenil 6.3
Interferon alfa-2a 6.3
Plaquenil 6.2
Anagrelide 6.2
Amprolium 6.0
Ambisome 5.8
AmBisome 5.8
Genasense 5.8
Methylcellulose 5.8
Tenecteplase 5.8
Biltricide 5.7
Fansidar 5.7
Fansidar 5.7
Midostaurin 5.7
Revlimid 5.5
Oxaliplatin 5.4
Miltefosine 5.3
Lenalidomide 5.3
Pentostam 5.3
Ziconotide 5.2
Artemether 5.1
Pegasys 5.1
Fludarabine 5.1
Azacytidine 5.1
Ovulen 5.1
Rituximab 5.1
Idarubicin 5.0
Tocilizumab 4.9
CA-074 4.8
Prednisone 4.8
Intron A 4.8
Vindesine 4.8
Dipyrone 4.8
Vindesine 4.7
Portal 4.7
Anakinra 4.7
Clodronate 4.7
MDS 4.6
Intron A 4.6
Intron A 4.6
Vicryl 4.6
-deoxyadenosine 4.5
Trabectedin 4.5
Campath 4.4
Campath 4.4
Senna 4.4
Lead acetate 4.4
Senna 4.3
Calcipotriol 4.3
Sonazoid 4.3
Tetanus toxoid 4.2
Imiquimod 4.2
PMEA 4.1
Daclizumab 4.1
Abatacept 4.0
Pefloxacin 4.0
VCR 4.0
G-CSF 4.0
BLyS 4.0
Epoetin alfa 4.0
Imatinib 4.0
Prednisolone 3.9
Estriol 3.9
ARA-C 3.8
AZT 3.7
Serum albumin 3.7
TFT 3.7
Asparaginase 3.6
more...
Enzyme
porphobilinogenase 8.1
glucocerebrosidase 6.9
STK4 6.2
prolidase 6.2
proprotein convertase 1 6.1
LDT 5.8
caspase-10 5.2
caspase-10 5.1
phosphoglyceromutase 5.1
galactose-1-phosphate uridylyltransferase 4.9
ribose-5-phosphate isomerase 4.8
alpha-N-acetylglucosaminidase 4.8
CD10 4.7
PHT 4.7
focal adhesion kinase 4.6
prephenate dehydratase 4.4
TdT 4.4
glucosylceramide synthase 4.3
AST 4.3
CD13 4.2
Rex 4.1
BMT 4.0
uridyltransferase 3.9
DNase II 3.9
lactic acid dehydrogenase 3.8
type III procollagen 3.8
granzyme B 3.8
lactic acid dehydrogenase 3.8
lecithin:cholesterol acyltransferase 3.7
GAR 3.7
cathepsin S 3.7
nucleotidase 3.6
CPL 3.6
aspartate aminotransferase 3.6
asparaginase 3.6
lactate dehydrogenase 3.6
alanine aminotransferase 3.4
beta-glucosidase 3.4
acid phosphatase 3.4
beta-glucosidase 3.4
inositol phosphatase 3.3
disulfide reductase 3.3
caspase-11 3.2
gamma-glutamyl transpeptidase 3.2
caspase-11 3.2
alkaline phosphatase 3.2
phosphoglycerate kinase 3.2
nicotinamide phosphoribosyltransferase 3.1
pyruvate kinase 3.1
alpha-L-iduronidase 3.1
CEP 3.1
lactic acid dehydrogenase 3.1
mevalonate kinase 3.1
mannosidase II 3.1
transaldolase 3.0
3'-exonuclease 3.0
Thy1 3.0
cholesterol acyltransferase 3.0
CGT 2.9
LPL 2.8
tryptase 2.8
adenosine deaminase 2.8
purine nucleoside phosphorylase 2.8
adenosine deaminase 2.8
DAT 2.7
alpha-L-fucosidase 2.7
matriptase 2.7
dihydroorotate dehydrogenase 2.7
dihydroorotate dehydrogenase 2.7
ceruloplasmin 2.7
alpha-L-fucosidase 2.6
thiopurine methyltransferase 2.5
CEP 2.5
branching enzyme 2.4
lysozyme 2.4
thromboplastin 2.4
factor C 2.3
DCF 2.3
neutral sphingomyelinase 2.3
polynucleotide kinase 2.3
more...
Compound
CI-501 9.7
2-Aminobiphenyl 9.3
AB-132 9.1
Imexon 8.7
RPCNU 8.7
3-Deazaguanine 8.7
2-Deoxy-D-galactose 8.7
Pipobroman 8.7
2,4,6-octatrienoic acid 8.1
No. 118 8.0
Oxamniquine 7.6
Ailanthone 7.6
hexan-2-one 7.4
Pyran 7.4
ara-AMP 7.3
ara-AMP 7.3
Ailanthone 7.3
Deoxycoformycin 7.2
Prednimustine 7.2
Oxymetholone 7.1
uroporphyrin I 7.0
Reticulin 6.9
Proguanil 6.7
HBB 6.7
Uroporphyrinogen III 6.7
MCNU 6.6
Mibolerone 6.6
C6H8O7 6.5
Fludarabine phosphate 6.3
Chlorambucil 6.1
CIPC 6.0
Butyl benzyl phthalate 5.9
cyclohexanone oxime 5.9
Nodular 5.9
Busulfan 5.8
Glucosylceramide 5.8
Psychosine 5.7
Hydroxyurea 5.6
CD 3 5.6
MIDA 5.6
Halofantrine 5.4
Castanospermine 5.4
Praziquantel 5.4
Diphenyl diselenide 5.4
Hemoglobin 5.3
Levan 5.3
ABPP 5.3
Diallyl sulfide 5.2
CPH 5.2
1-(3-chlorophenyl)piperazine 5.1
aceturate 5.1
2-ethoxyethanol 5.1
Sulfadoxine 5.0
Coumestrol 5.0
Phenylhydrazine 5.0
Benznidazole 5.0
Diallyl disulfide 5.0
Benznidazole 5.0
Benznidazole 5.0
Diallyl disulfide 5.0
Pyrimethamine 4.9
MCH 4.9
3-Deazaneplanocin 4.9
IVE 4.9
2,4-DNT 4.9
hexanamide 4.9
Berenil 4.9
2-ethoxyethanol 4.9
CeCl3 4.8
BCR 4.8
Sulfinpyrazone 4.8
Bantu 4.8
Tuftsin 4.8
docosanoic acid 4.7
PHT 4.7
NFS 4.7
Meglumine 4.6
6-Thioguanine 4.6
butyl nitrite 4.6
6-Mercaptopurine 4.6
more...