Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0038002 (splenomegaly)
9,873 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 654
lymphoid 535
hemoglobin 469
CD4 294
She 269
cytokine 263
erythroid 242
CD8 236
JAK2 236
interferon 215
hairy 166
thymus 153
CD5 147
Mol 136
alkaline phosphatase 136
CD20 135
IFN 129
erythropoietin 115
ferritin 105
CD25 99
HLA 97
CD19 97
Fas 94
lactate dehydrogenase 93
IL-6 90
granulocyte 88
non-Hodgkin's lymphoma 87
TNF 85
CD11c 82
collagen 81
CD10 79
IgA 79
LDH 76
IL-10 73
IFN-gamma 72
JAK1 71
albumin 68
megakaryocyte 67
lipopolysaccharide 65
prothrombin 64
IL-4 63
CLL 62
glucocerebrosidase 60
CD34 60
tyrosine kinase 58
DBA 58
BCR 56
IL-2 55
CHOP 55
MRI 54
white cell 54
tumor necrosis factor 53
granulocyte colony-stimulating factor 52
CD23 52
MPL 50
TCR 50
rheumatoid factor 50
CSF 49
serum albumin 49
SLAM-associated protein 49
aspartate aminotransferase 48
Janus kinase 48
interferon-alpha 48
STAT 47
alanine aminotransferase 44
cyclin D1 44
nodal 43
acid phosphatase 43
C-reactive protein 42
CD45 42
LPS 42
Calreticulin 41
interleukin-6 41
ABL 40
tartrate-resistant acid phosphatase 40
interleukin-2 39
p53 38
IgG3 38
BCR-ABL1 38
fibrinogen 38
more...
Disease
anemia 1527
lymphadenopathy 1273
thrombocytopenia 1044
cancer 842
leukemia 740
lymphoma 715
tumor 689
portal hypertension 561
myelofibrosis 495
pancytopenia 471
malaria 417
cirrhosis 407
myeloproliferative disorders 330
hypersplenism 316
chronic lymphocytic leukemia 281
primary myelofibrosis 274
lymphocytosis 271
polycythemia vera 270
hepatitis 248
chronic myeloid leukemia 247
hemolytic anemia 247
immunodeficiency 247
hairy cell leukemia 233
esophageal varices 233
neutropenia 229
thalassemia 227
systemic lupus erythematosus 226
thrombocytosis 213
leishmaniasis 212
schistosomiasis 206
rash 200
essential thrombocythemia 197
Hodgkin's disease 196
chronic lymphocytic leukemia 194
AIDS 193
HIV 191
infectious diseases 181
Gaucher disease 170
liver disease 165
Epstein 165
arthritis 163
leukopenia 162
sepsis 159
acute myeloid leukemia 155
B-cell lymphoma 153
autoimmune disease 152
varices 147
lupus 140
kala-azar 135
sepsis 132
tuberculosis 130
rheumatoid arthritis 129
pneumonia 129
hemophagocytic lymphohistiocytosis 127
lupus 124
myelodysplastic syndrome 123
hypergammaglobulinemia 120
glomerulonephritis 118
infectious mononucleosis 117
Spleen 111
sickle cell disease 110
acute lymphoblastic leukemia 109
virus infection 105
sarcoidosis 104
non-Hodgkin's lymphoma 103
acute leukemia 101
cytomegalovirus 101
Leukemia 99
Infection 97
multiple myeloma 96
eosinophilia 90
Felty's syndrome 88
T-cell lymphoma 87
vasculitis 85
pruritus 83
hereditary spherocytosis 82
Schistosoma mansoni 81
splenic marginal zone lymphoma 81
proteinuria 80
graft-versus-host disease 80
more...
Symptom
splenomegaly 9873
hepatomegaly 1222
abdominal pain 333
diarrhea 215
fatigue 198
hepatosplenomegaly 193
pain 181
pallor 140
anorexia 136
vomiting 129
weakness 112
headache 95
lethargy 93
dyspnea 80
cough 79
Ill 78
arthralgia 72
fever of unknown origin 65
nausea 65
night sweats 56
bone pain 49
myalgia 44
respiratory distress 43
chills 42
cachexia 40
abdominal discomfort 37
sore throat 37
seizures 36
asthenia 34
discomfort 30
epigastric pain 29
discomfort 29
erythema 28
back pain 24
emaciation 23
ataxia 23
anesthesia 22
chest pain 19
left upper quadrant pain 19
tachypnea 17
nausea and vomiting 17
decreased appetite 17
clubbing 15
exhaustion 15
acute abdomen 15
dizziness 14
shortness of breath 14
cyanosis 14
dysarthria 12
collapse 12
constipation 12
acute abdominal pain 12
numbness 11
hypotonia 11
hemoptysis 11
hypoproteinemia 10
hypothermia 10
paresis 10
sleepiness 9
apathy 9
intestinal bleeding 8
periorbital edema 8
oliguria 8
abdominal fullness 7
prostration 7
dystonia 7
colic 7
dark urine 7
Physical findings 7
spasticity 7
cerebellar ataxia 7
regurgitation 6
shoulder pain 6
polyuria 6
angina 6
incoordination 6
syncope 6
livedo 6
rigors 6
HSA 6
more...
Drug
IFN-gamma 70
CSF 64
IL-2 56
Dermatol 44
Portal 34
Rituximab 30
G-CSF 26
MDS 17
CTX 17
-deoxyadenosine 15
ampicillin 14
Cardiovasc 13
Oxaliplatin 12
Imatinib 12
AZT 11
AZT 11
vitamin E 10
Kenyan 9
ROS 9
AmBisome 9
Prednisone 9
lysine 9
Cerezyme 8
Lenalidomide 8
VCR 8
Indomethacin 8
Prednisolone 7
Asthma 7
Adriamycin 6
Ceredase 6
Glucantime 6
Campath 5
Fludarabine 5
Serum albumin 5
Gleevec 5
Campath 5
Leaf 5
Heme 5
p75 4
Gel 4
Cerezyme 4
PMEA 4
ETS 4
Norplant 4
Fansidar 4
Vicryl 4
Fansidar 4
Dakar 4
Tocilizumab 4
BCG vaccine 4
Doxycycline 4
ROC 4
Gastro 3
Imiquimod 3
Miltefosine 3
Azithromycin 3
Asn 3
Dial 3
lactose 3
Monit 3
CTX 3
ENT 3
CTX 3
PTH 3
Miglustat 3
Nephron 3
Fluorescein 3
Lovastatin 2
Histamine 2
Anagrelide 2
TEL 2
IL-11 2
IL-1ra 2
Senna 2
Clodronate 2
Artemether 2
Anakinra 2
Acyclovir 2
VCR 2
TAC 2
more...
Enzyme
focal adhesion kinase 335
alkaline phosphatase 136
lactate dehydrogenase 107
alanine aminotransferase 90
aspartate aminotransferase 82
CD10 81
ERK 73
glucocerebrosidase 54
acid phosphatase 43
peroxidase 38
AST 37
lysozyme 34
mitogen-activated protein kinase 34
reverse transcriptase 29
gamma-glutamyl transpeptidase 26
thromboplastin 21
CD13 21
ACE 19
protein kinase 15
acetylcholinesterase 15
APC 15
granzyme B 14
pyruvate kinase 14
BMT 13
TdT 12
neuraminidase 12
superoxide dismutase 12
lipase 12
beta-glucosidase 11
adenosine deaminase 11
thrombin 11
adenosine deaminase 11
prolidase 11
asparaginase 10
ceruloplasmin 10
plasmin 10
catalase 10
glucose-6-phosphate dehydrogenase 10
protein kinase C 10
caspase-8 9
beta-glucosidase 9
cholinesterase 8
NOS 8
transcriptase 7
RNA polymerase 7
lipoprotein lipase 7
NO synthase 6
caspase-1 6
glutathione peroxidase 6
luciferase 6
trypsin 6
phosphoglycerate kinase 6
tryptase 6
beta-glucuronidase 5
lecithin:cholesterol acyltransferase 5
phosphatidylinositol 3-kinase 5
thymidine kinase 5
Rex 5
porphobilinogenase 5
endonuclease 5
cholesterol acyltransferase 5
MEK 5
AMP-activated protein kinase 5
beta-galactosidase 4
aldolase 4
MIP 4
5'-nucleotidase 4
RNase 4
creatine kinase 4
RNase 4
caspase-3 4
proteasome 4
nucleotidase 4
NADPH oxidase 3
renin 3
neutrophil elastase 3
purine nucleoside phosphorylase 3
NADPH oxidase 3
CDR 3
PARP 3
more...
Compound
Clin 742
Dec 702
DNA 401
iron 166
His 120
water 115
Hemoglobin 90
oxygen 88
TNF 85
sodium 71
DBA 60
DBA 58
DBA 58
BCR 56
creatinine 50
calcium 46
acetate 42
ABL 40
glucose 40
urea 35
leucine 34
tyrosine 33
phosphate 33
sulfate 31
BCG 29
nitric oxide 28
nitrogen 27
HBB 23
copper 21
arginine 19
galactose 19
zinc 18
alanine 18
Nodular 17
ATP 17
CTX 17
Hydroxyurea 17
phosphorus 16
Cardiol 16
DIC 15
PAS 14
Asp 14
ethanol 14
cysteine 14
AZT 14
Optimal 13
GSH 13
MCH 13
GSH 13
proline 13
ANA 12
ANA 12
Amphotericin B 12
GM1 11
potassium 11
vinyl 11
Cyclosporine 11
retinoic acid 11
lysine 11
Phe 11
Deoxycoformycin 10
salt 10
Prednisone 10
cadmium 10
Pac 10
silver 10
CO2 10
Adriamycin 10
Rapamycin 9
PPD 9
Busulfan 9
Neo 9
Praziquantel 9
nitrate 9
phenol 9
A 3 9
A 42 9
PPD 9
TAR 8
ITP 8
more...