Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0038002 (
splenomegaly
)
9,873
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
Sep
654
lymphoid
535
hemoglobin
469
CD4
294
She
269
cytokine
263
erythroid
242
CD8
236
JAK2
236
interferon
215
hairy
166
thymus
153
CD5
147
Mol
136
alkaline phosphatase
136
CD20
135
IFN
129
erythropoietin
115
ferritin
105
CD25
99
HLA
97
CD19
97
Fas
94
lactate dehydrogenase
93
IL-6
90
granulocyte
88
non-Hodgkin's lymphoma
87
TNF
85
CD11c
82
collagen
81
CD10
79
IgA
79
LDH
76
IL-10
73
IFN-gamma
72
JAK1
71
albumin
68
megakaryocyte
67
lipopolysaccharide
65
prothrombin
64
IL-4
63
CLL
62
glucocerebrosidase
60
CD34
60
tyrosine kinase
58
DBA
58
BCR
56
IL-2
55
CHOP
55
MRI
54
white cell
54
tumor necrosis factor
53
granulocyte colony-stimulating factor
52
CD23
52
MPL
50
TCR
50
rheumatoid factor
50
CSF
49
serum albumin
49
SLAM-associated protein
49
aspartate aminotransferase
48
Janus kinase
48
interferon-alpha
48
STAT
47
alanine aminotransferase
44
cyclin D1
44
nodal
43
acid phosphatase
43
C-reactive protein
42
CD45
42
LPS
42
Calreticulin
41
interleukin-6
41
ABL
40
tartrate-resistant acid phosphatase
40
interleukin-2
39
p53
38
IgG3
38
BCR-ABL1
38
fibrinogen
38
more...
Disease
anemia
1527
lymphadenopathy
1273
thrombocytopenia
1044
cancer
842
leukemia
740
lymphoma
715
tumor
689
portal hypertension
561
myelofibrosis
495
pancytopenia
471
malaria
417
cirrhosis
407
myeloproliferative disorders
330
hypersplenism
316
chronic lymphocytic leukemia
281
primary myelofibrosis
274
lymphocytosis
271
polycythemia vera
270
hepatitis
248
chronic myeloid leukemia
247
hemolytic anemia
247
immunodeficiency
247
hairy cell leukemia
233
esophageal varices
233
neutropenia
229
thalassemia
227
systemic lupus erythematosus
226
thrombocytosis
213
leishmaniasis
212
schistosomiasis
206
rash
200
essential thrombocythemia
197
Hodgkin's disease
196
chronic lymphocytic leukemia
194
AIDS
193
HIV
191
infectious diseases
181
Gaucher disease
170
liver disease
165
Epstein
165
arthritis
163
leukopenia
162
sepsis
159
acute myeloid leukemia
155
B-cell lymphoma
153
autoimmune disease
152
varices
147
lupus
140
kala-azar
135
sepsis
132
tuberculosis
130
rheumatoid arthritis
129
pneumonia
129
hemophagocytic lymphohistiocytosis
127
lupus
124
myelodysplastic syndrome
123
hypergammaglobulinemia
120
glomerulonephritis
118
infectious mononucleosis
117
Spleen
111
sickle cell disease
110
acute lymphoblastic leukemia
109
virus infection
105
sarcoidosis
104
non-Hodgkin's lymphoma
103
acute leukemia
101
cytomegalovirus
101
Leukemia
99
Infection
97
multiple myeloma
96
eosinophilia
90
Felty's syndrome
88
T-cell lymphoma
87
vasculitis
85
pruritus
83
hereditary spherocytosis
82
Schistosoma mansoni
81
splenic marginal zone lymphoma
81
proteinuria
80
graft-versus-host disease
80
more...
Symptom
splenomegaly
9873
hepatomegaly
1222
abdominal pain
333
diarrhea
215
fatigue
198
hepatosplenomegaly
193
pain
181
pallor
140
anorexia
136
vomiting
129
weakness
112
headache
95
lethargy
93
dyspnea
80
cough
79
Ill
78
arthralgia
72
fever of unknown origin
65
nausea
65
night sweats
56
bone pain
49
myalgia
44
respiratory distress
43
chills
42
cachexia
40
abdominal discomfort
37
sore throat
37
seizures
36
asthenia
34
discomfort
30
epigastric pain
29
discomfort
29
erythema
28
back pain
24
emaciation
23
ataxia
23
anesthesia
22
chest pain
19
left upper quadrant pain
19
tachypnea
17
nausea and vomiting
17
decreased appetite
17
clubbing
15
exhaustion
15
acute abdomen
15
dizziness
14
shortness of breath
14
cyanosis
14
dysarthria
12
collapse
12
constipation
12
acute abdominal pain
12
numbness
11
hypotonia
11
hemoptysis
11
hypoproteinemia
10
hypothermia
10
paresis
10
sleepiness
9
apathy
9
intestinal bleeding
8
periorbital edema
8
oliguria
8
abdominal fullness
7
prostration
7
dystonia
7
colic
7
dark urine
7
Physical findings
7
spasticity
7
cerebellar ataxia
7
regurgitation
6
shoulder pain
6
polyuria
6
angina
6
incoordination
6
syncope
6
livedo
6
rigors
6
HSA
6
more...
Drug
IFN-gamma
70
CSF
64
IL-2
56
Dermatol
44
Portal
34
Rituximab
30
G-CSF
26
MDS
17
CTX
17
-deoxyadenosine
15
ampicillin
14
Cardiovasc
13
Oxaliplatin
12
Imatinib
12
AZT
11
AZT
11
vitamin E
10
Kenyan
9
ROS
9
AmBisome
9
Prednisone
9
lysine
9
Cerezyme
8
Lenalidomide
8
VCR
8
Indomethacin
8
Prednisolone
7
Asthma
7
Adriamycin
6
Ceredase
6
Glucantime
6
Campath
5
Fludarabine
5
Serum albumin
5
Gleevec
5
Campath
5
Leaf
5
Heme
5
p75
4
Gel
4
Cerezyme
4
PMEA
4
ETS
4
Norplant
4
Fansidar
4
Vicryl
4
Fansidar
4
Dakar
4
Tocilizumab
4
BCG vaccine
4
Doxycycline
4
ROC
4
Gastro
3
Imiquimod
3
Miltefosine
3
Azithromycin
3
Asn
3
Dial
3
lactose
3
Monit
3
CTX
3
ENT
3
CTX
3
PTH
3
Miglustat
3
Nephron
3
Fluorescein
3
Lovastatin
2
Histamine
2
Anagrelide
2
TEL
2
IL-11
2
IL-1ra
2
Senna
2
Clodronate
2
Artemether
2
Anakinra
2
Acyclovir
2
VCR
2
TAC
2
more...
Enzyme
focal adhesion kinase
335
alkaline phosphatase
136
lactate dehydrogenase
107
alanine aminotransferase
90
aspartate aminotransferase
82
CD10
81
ERK
73
glucocerebrosidase
54
acid phosphatase
43
peroxidase
38
AST
37
lysozyme
34
mitogen-activated protein kinase
34
reverse transcriptase
29
gamma-glutamyl transpeptidase
26
thromboplastin
21
CD13
21
ACE
19
protein kinase
15
acetylcholinesterase
15
APC
15
granzyme B
14
pyruvate kinase
14
BMT
13
TdT
12
neuraminidase
12
superoxide dismutase
12
lipase
12
beta-glucosidase
11
adenosine deaminase
11
thrombin
11
adenosine deaminase
11
prolidase
11
asparaginase
10
ceruloplasmin
10
plasmin
10
catalase
10
glucose-6-phosphate dehydrogenase
10
protein kinase C
10
caspase-8
9
beta-glucosidase
9
cholinesterase
8
NOS
8
transcriptase
7
RNA polymerase
7
lipoprotein lipase
7
NO synthase
6
caspase-1
6
glutathione peroxidase
6
luciferase
6
trypsin
6
phosphoglycerate kinase
6
tryptase
6
beta-glucuronidase
5
lecithin:cholesterol acyltransferase
5
phosphatidylinositol 3-kinase
5
thymidine kinase
5
Rex
5
porphobilinogenase
5
endonuclease
5
cholesterol acyltransferase
5
MEK
5
AMP-activated protein kinase
5
beta-galactosidase
4
aldolase
4
MIP
4
5'-nucleotidase
4
RNase
4
creatine kinase
4
RNase
4
caspase-3
4
proteasome
4
nucleotidase
4
NADPH oxidase
3
renin
3
neutrophil elastase
3
purine nucleoside phosphorylase
3
NADPH oxidase
3
CDR
3
PARP
3
more...
Compound
Clin
742
Dec
702
DNA
401
iron
166
His
120
water
115
Hemoglobin
90
oxygen
88
TNF
85
sodium
71
DBA
60
DBA
58
DBA
58
BCR
56
creatinine
50
calcium
46
acetate
42
ABL
40
glucose
40
urea
35
leucine
34
tyrosine
33
phosphate
33
sulfate
31
BCG
29
nitric oxide
28
nitrogen
27
HBB
23
copper
21
arginine
19
galactose
19
zinc
18
alanine
18
Nodular
17
ATP
17
CTX
17
Hydroxyurea
17
phosphorus
16
Cardiol
16
DIC
15
PAS
14
Asp
14
ethanol
14
cysteine
14
AZT
14
Optimal
13
GSH
13
MCH
13
GSH
13
proline
13
ANA
12
ANA
12
Amphotericin B
12
GM1
11
potassium
11
vinyl
11
Cyclosporine
11
retinoic acid
11
lysine
11
Phe
11
Deoxycoformycin
10
salt
10
Prednisone
10
cadmium
10
Pac
10
silver
10
CO2
10
Adriamycin
10
Rapamycin
9
PPD
9
Busulfan
9
Neo
9
Praziquantel
9
nitrate
9
phenol
9
A 3
9
A 42
9
PPD
9
TAR
8
ITP
8
more...