Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0038002 (splenomegaly)
 9,873 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 654
lymphoid 535
hemoglobin 469
CD4 294
She 269
cytokine 263
erythroid 242
CD8 236
JAK2 236
interferon 215
hairy 166
thymus 153
CD5 147
Mol 136
alkaline phosphatase 136
CD20 135
IFN 129
erythropoietin 115
ferritin 105
CD25 99
CD19 97
HLA 97
Fas 94
lactate dehydrogenase 93
IL-6 90
granulocyte 88
non-Hodgkin's lymphoma 87
TNF 85
CD11c 82
collagen 81
CD10 79
IgA 79
LDH 76
IL-10 73
IFN-gamma 72
JAK1 71
albumin 68
megakaryocyte 67
lipopolysaccharide 65
prothrombin 64
IL-4 63
CLL 62
glucocerebrosidase 60
CD34 60
tyrosine kinase 58
DBA 58
BCR 56
IL-2 55
CHOP 55
MRI 54
white cell 54
tumor necrosis factor 53
granulocyte colony-stimulating factor 52
CD23 52
rheumatoid factor 50
TCR 50
MPL 50
CSF 49
serum albumin 49
SLAM-associated protein 49
interferon-alpha 48
Janus kinase 48
aspartate aminotransferase 48
STAT 47
cyclin D1 44
alanine aminotransferase 44
nodal 43
acid phosphatase 43
CD45 42
C-reactive protein 42
LPS 42
interleukin-6 41
Calreticulin 41
ABL 40
tartrate-resistant acid phosphatase 40
interleukin-2 39
BCR-ABL1 38
p53 38
fibrinogen 38
Janus kinase 2 38
IgG3 38
CD103 37
AST 37
CD56 37
HLA-DR 36
thrombopoietin 36
CD11b 36
CD22 36
B12 35
ESR 35
beta-globin 34
FDG 34
lysozyme 34
IgE 34
TNF-alpha 33
surface antigen 33
AML 33
interferon-gamma 32
mast cell 31
Pol 30
CD2 30
CD30 30
ALL 29
imiglucerase 29
IL-17 29
serum protein 29
B10 28
transferrin 28
CD7 28
CML 27
membrane-bound 27
gut 27
CD43 26
natural killer cell 26
bcr 26
Bcl-2 26
MHC 26
CD68 26
G-CSF 26
CD40 25
STAT3 25
B-CLL 24
BCR/ABL 24
major histocompatibility complex 24
T cell receptor 24
granulocyte-macrophage 24
STAT5 23
chemokine 23
IL-5 23
HBB 23
myeloperoxidase 23
CD21 23
IL-1 23
CD13 23
Gen 23
FAB 22
TLR4 22
BRAF 22
Hop 22
FAS 21
macrophage colony-stimulating factor 21
X-linked 21
CD79a 21
PHA 21
glycoprotein 21
membrane protein 21
CD38 20
Cytokine 20
Fas ligand 20
thromboplastin 20
TLR9 20
c-kit 19
MHC class II 19
ASXL1 19
insulin 19
methemoglobin 19
esterase 19
reserved 19
Thy-1 19
vascular endothelial growth factor 19
more...
Disease
anemia 1527
lymphadenopathy 1273
thrombocytopenia 1044
cancer 842
leukemia 740
lymphoma 715
tumor 689
portal hypertension 561
myelofibrosis 495
pancytopenia 471
malaria 417
cirrhosis 407
myeloproliferative disorders 330
hypersplenism 316
chronic lymphocytic leukemia 281
primary myelofibrosis 274
lymphocytosis 271
polycythemia vera 270
hepatitis 248
immunodeficiency 247
hemolytic anemia 247
chronic myeloid leukemia 247
esophageal varices 233
hairy cell leukemia 233
neutropenia 229
thalassemia 227
systemic lupus erythematosus 226
thrombocytosis 213
leishmaniasis 212
schistosomiasis 206
rash 200
essential thrombocythemia 197
Hodgkin's disease 196
chronic lymphocytic leukemia 194
AIDS 193
HIV 191
infectious diseases 181
Gaucher disease 170
liver disease 165
Epstein 165
arthritis 163
leukopenia 162
sepsis 159
acute myeloid leukemia 155
B-cell lymphoma 153
autoimmune disease 152
varices 147
lupus 140
kala-azar 135
sepsis 132
tuberculosis 130
rheumatoid arthritis 129
pneumonia 129
hemophagocytic lymphohistiocytosis 127
lupus 124
myelodysplastic syndrome 123
hypergammaglobulinemia 120
glomerulonephritis 118
infectious mononucleosis 117
Spleen 111
sickle cell disease 110
acute lymphoblastic leukemia 109
virus infection 105
sarcoidosis 104
non-Hodgkin's lymphoma 103
cytomegalovirus 101
acute leukemia 101
Leukemia 99
Infection 97
multiple myeloma 96
eosinophilia 90
Felty's syndrome 88
T-cell lymphoma 87
vasculitis 85
pruritus 83
hereditary spherocytosis 82
Schistosoma mansoni 81
splenic marginal zone lymphoma 81
proteinuria 80
graft-versus-host disease 80
Mycobacterium 75
lymphoproliferative disorders 74
endocarditis 74
brucellosis 73
autoimmune hemolytic anemia 73
hepatitis B 73
disseminated intravascular coagulation 72
metastases 72
hypertension 70
cholestasis 69
mantle cell lymphoma 69
chronic hepatitis 67
EBV infection 65
rare disease 64
gallstones 64
carcinoma 64
West 63
hepatocellular carcinoma 63
tumor growth 63
depression 61
chronic liver disease 61
coagulopathy 60
hyperbilirubinemia 60
iron overload 59
sarcoma 58
DBA 58
renal disease 57
macroglobulinemia 56
erythrocytosis 56
chronic myelomonocytic leukemia 56
splenic infarction 56
idiopathic thrombocytopenic purpura 55
polycythemia 55
purpura 55
liver fibrosis 53
renal failure 53
heart failure 53
pancreatitis 51
angiosarcoma 51
lymphopenia 51
hematologic malignancies 51
hepatitis C 50
diabetes 49
viremia 49
dysplasia 48
blast crisis 48
plaque 48
hemangioma 47
hemoglobinopathies 46
interstitial pneumonia 46
encephalopathy 46
typhoid 46
hypercalcemia 45
Friend leukemia 45
hypogammaglobulinemia 44
petechiae 44
autoimmune lymphoproliferative syndrome 44
prolymphocytic leukemia 44
gammopathy 44
colitis 42
viral hepatitis 42
thrombocytopenic purpura 42
cold 42
pharyngitis 42
erythroleukemia 41
ABL 41
melanoma 40
Still's disease 40
malnutrition 39
inflammatory bowel disease 39
Kaposi's sarcoma 39
B-cell lymphomas 39
dermatitis 38
polyneuropathy 38
peripheral neuropathy 37
myelosuppression 37
hypofibrinogenemia 37
Schistosoma mansoni infection 36
myocarditis 36
Niemann-Pick 36
more...
Symptom
splenomegaly 9873
hepatomegaly 1222
abdominal pain 333
diarrhea 215
fatigue 198
hepatosplenomegaly 193
pain 181
pallor 140
anorexia 136
vomiting 129
weakness 112
headache 95
lethargy 93
dyspnea 80
cough 79
Ill 78
arthralgia 72
nausea 65
fever of unknown origin 65
night sweats 56
bone pain 49
myalgia 44
respiratory distress 43
chills 42
cachexia 40
abdominal discomfort 37
sore throat 37
seizures 36
asthenia 34
discomfort 30
epigastric pain 29
discomfort 29
erythema 28
back pain 24
ataxia 23
emaciation 23
anesthesia 22
left upper quadrant pain 19
chest pain 19
decreased appetite 17
nausea and vomiting 17
tachypnea 17
clubbing 15
exhaustion 15
acute abdomen 15
dizziness 14
shortness of breath 14
cyanosis 14
acute abdominal pain 12
dysarthria 12
constipation 12
collapse 12
hemoptysis 11
hypotonia 11
numbness 11
hypothermia 10
hypoproteinemia 10
paresis 10
apathy 9
sleepiness 9
periorbital edema 8
oliguria 8
intestinal bleeding 8
abdominal fullness 7
prostration 7
dystonia 7
cerebellar ataxia 7
colic 7
spasticity 7
Physical findings 7
dark urine 7
syncope 6
incoordination 6
HSA 6
angina 6
livedo 6
polyuria 6
rigors 6
regurgitation 6
shoulder pain 6
polydipsia 5
agitation 5
leg pain 5
paresthesia 5
productive cough 5
chronic cough 5
acute pain 5
nasal discharge 5
vertigo 4
non-productive cough 4
lassitude 4
right upper quadrant pain 4
dysuria 4
consciousness disturbance 4
ophthalmoplegia 4
pedal edema 4
dry skin 4
Kayser-Fleischer ring 4
hemiplegia 4
hip pain 4
tremor 4
tense 3
paraparesis 3
skin damage 3
adenitis 3
generalized abdominal pain 3
abdominal cramps 3
enanthema 3
analgesia 3
exertional dyspnea 3
Respiratory symptoms 3
torticollis 3
stomach pain 2
hoarseness 2
photophobia 2
blurred vision 2
tingling 2
low back pain 2
neck stiffness 2
pleuritic chest pain 2
clumsiness 2
overweight 2
myoclonus 2
generalized pain 2
knee pain 2
pelvic pain 2
tenesmus 2
flank pain 2
renal colic 2
Gastrointestinal symptoms 2
persistent cough 2
tonic-clonic seizure 2
sneezing 2
Neurologic symptoms 2
Multiple symptoms 1
hunger 1
hypercapnia 1
monoplegia 1
Flu-like symptoms 1
Fluctuation 1
Visual disturbances 1
right lower quadrant pain 1
impaired motor coordination 1
excessive sweating 1
catarrh 1
Kehr's sign 1
exertional chest pain 1
Venous hum 1
leg edema 1
labored breathing 1
lightheadedness 1
dysesthesia 1
thinning 1
meningism 1
Scrotal pain 1
chorea 1
muscle cramps 1
muscle stiffness 1
Osler's nodes 1
hypertonia 1
more...
Drug
IFN-gamma 70
CSF 64
IL-2 56
Dermatol 44
Portal 34
Rituximab 30
G-CSF 26
CTX 17
MDS 17
-deoxyadenosine 15
ampicillin 14
Cardiovasc 13
Imatinib 12
Oxaliplatin 12
AZT 11
AZT 11
vitamin E 10
Prednisone 9
lysine 9
AmBisome 9
ROS 9
Kenyan 9
Lenalidomide 8
Cerezyme 8
Indomethacin 8
VCR 8
Prednisolone 7
Asthma 7
Ceredase 6
Glucantime 6
Adriamycin 6
Leaf 5
Heme 5
Campath 5
Campath 5
Gleevec 5
Serum albumin 5
Fludarabine 5
Dakar 4
Doxycycline 4
Tocilizumab 4
p75 4
PMEA 4
ETS 4
BCG vaccine 4
ROC 4
Norplant 4
Vicryl 4
Fansidar 4
Gel 4
Fansidar 4
Cerezyme 4
Miglustat 3
Dial 3
Azithromycin 3
Miltefosine 3
CTX 3
lactose 3
CTX 3
Imiquimod 3
Asn 3
ENT 3
Gastro 3
Monit 3
PTH 3
Nephron 3
Fluorescein 3
CDP 2
Paraffin 2
IL-11 2
Anagrelide 2
Histamine 2
Artemether 2
Vitamin E 2
Etoposide 2
TAC 2
VCR 2
Clodronate 2
Lumefantrine 2
Senna 2
Idarubicin 2
TAK 2
Senna 2
pyridoxal phosphate 2
Pentostam 2
Nephron 2
PMPA 2
Bortezomib 2
Itraconazole 2
EE2 2
Albumin 2
Acyclovir 2
Fraction 2
ICI 2
Dasatinib 2
Anakinra 2
Lovastatin 2
IFN-beta 2
IL-1ra 2
TEL 2
Methylcellulose 2
Tenofovir 1
MAP 1
Artesunate 1
Bayer 1
Acacia 1
Halofantrine hydrochloride 1
Isoniazid 1
DNase I 1
CPR 1
Daclizumab 1
Trabectedin 1
Abatacept 1
CTT 1
Nitric Oxide 1
BLyS 1
Cellulose acetate 1
CAM 1
Fluorescein 1
Alliance 1
Alteplase 1
Dextrose 1
Ovulen 1
Ambisome 1
DFP 1
Ganciclovir 1
AGG 1
NBT 1
Roferon A 1
ADM 1
CPT-11 1
Clonidine 1
Spectrum 1
Asparaginase 1
Rutin 1
CTC 1
Intron A 1
Methylene blue 1
Estriol 1
Intron A 1
Pefloxacin 1
LCM 1
Phenytoin 1
Midostaurin 1
LCM 1
Ethanol 1
Tetanus toxoid 1
Methylprednisolone 1
Thioguanine 1
Simvastatin 1
Vitamin K 1
Ziconotide 1
Plaquenil 1
Misoprostol 1
Biltricide 1
CTC 1
Nipent 1
Vitamin B 1
Dipyrone 1
EPA 1
more...
Enzyme
focal adhesion kinase 335
alkaline phosphatase 136
lactate dehydrogenase 107
alanine aminotransferase 90
aspartate aminotransferase 82
CD10 81
ERK 73
glucocerebrosidase 54
acid phosphatase 43
peroxidase 38
AST 37
mitogen-activated protein kinase 34
lysozyme 34
reverse transcriptase 29
gamma-glutamyl transpeptidase 26
CD13 21
thromboplastin 21
ACE 19
acetylcholinesterase 15
protein kinase 15
APC 15
pyruvate kinase 14
granzyme B 14
BMT 13
neuraminidase 12
lipase 12
TdT 12
superoxide dismutase 12
thrombin 11
prolidase 11
beta-glucosidase 11
adenosine deaminase 11
adenosine deaminase 11
protein kinase C 10
asparaginase 10
ceruloplasmin 10
plasmin 10
catalase 10
glucose-6-phosphate dehydrogenase 10
beta-glucosidase 9
caspase-8 9
NOS 8
cholinesterase 8
lipoprotein lipase 7
transcriptase 7
RNA polymerase 7
trypsin 6
caspase-1 6
glutathione peroxidase 6
tryptase 6
phosphoglycerate kinase 6
luciferase 6
NO synthase 6
endonuclease 5
phosphatidylinositol 3-kinase 5
porphobilinogenase 5
lecithin:cholesterol acyltransferase 5
AMP-activated protein kinase 5
thymidine kinase 5
MEK 5
beta-glucuronidase 5
Rex 5
cholesterol acyltransferase 5
5'-nucleotidase 4
aldolase 4
RNase 4
RNase 4
beta-galactosidase 4
creatine kinase 4
MIP 4
caspase-3 4
proteasome 4
nucleotidase 4
purine nucleoside phosphorylase 3
DCF 3
phosphoenolpyruvate carboxykinase 3
PARP 3
CDR 3
ATPase 3
ribonucleotide reductase 3
ribonucleotide reductase 3
phosphoenolpyruvate carboxykinase 3
heme oxygenase 3
phosphoenolpyruvate carboxykinase 3
type III procollagen 3
NADPH oxidase 3
NADPH oxidase 3
renin 3
Thy1 3
glucose-6-phosphatase 3
topoisomerase 3
calcineurin 3
topoisomerase 3
CYP3A4 3
glucosylceramide synthase 3
arginase 3
neutrophil elastase 3
LPL 3
DAT 3
kallikrein 2
thyroid peroxidase 2
PHT 2
IKK 2
BAL 2
phosphoglucose isomerase 2
cytochrome oxidase 2
aldehyde dehydrogenase 2
lactic acid dehydrogenase 2
lactic acid dehydrogenase 2
ricin 2
phospholipase A2 2
matrix metalloproteinase 9 2
LDT 2
phosphofructokinase 2
glutathione S-transferase 2
MEKK1 2
DNase 2
protein phosphatase 2A 2
collagenase 2
glutathione reductase 2
proteinase K 2
transpeptidase 2
peroxiredoxin 2
CEP 2
phosphoinositide 3-kinase 2
glyceraldehyde-3-phosphate dehydrogenase 2
malate dehydrogenase 2
CPR 2
P-glycoprotein 2
caspase-10 2
alpha-galactosidase 2
micrococcal nuclease 2
histone acetyltransferase 2
lactic acid dehydrogenase 2
phosphodiesterase 2
cathepsin G 2
CEP 2
demethylase 2
phospholipase C 2
caspase-10 2
cathepsin S 2
DNA polymerase 2
phosphoglyceromutase 2
DNase II 2
adenylate kinase 2
sulfatase 1
chondroitinase 1
nicotinamide phosphoribosyltransferase 1
galactose-1-phosphate uridylyltransferase 1
uridyltransferase 1
chondroitinase 1
CAD 1
tissue kallikrein 1
CAD 1
glyceraldehyde-3-phosphate dehydrogenase 1
cathepsin B 1
3'-exonuclease 1
mevalonate kinase 1
elastase 1
cathepsin L 1
more...
Compound
Clin 742
Dec 702
DNA 401
iron 166
His 120
water 115
Hemoglobin 90
oxygen 88
TNF 85
sodium 71
DBA 60
DBA 58
DBA 58
BCR 56
creatinine 50
calcium 46
acetate 42
glucose 40
ABL 40
urea 35
leucine 34
phosphate 33
tyrosine 33
sulfate 31
BCG 29
nitric oxide 28
nitrogen 27
HBB 23
copper 21
arginine 19
galactose 19
alanine 18
zinc 18
ATP 17
CTX 17
Nodular 17
Hydroxyurea 17
phosphorus 16
Cardiol 16
DIC 15
Asp 14
cysteine 14
ethanol 14
PAS 14
AZT 14
GSH 13
Optimal 13
proline 13
GSH 13
MCH 13
ANA 12
ANA 12
Amphotericin B 12
lysine 11
GM1 11
potassium 11
Cyclosporine 11
retinoic acid 11
vinyl 11
Phe 11
Prednisone 10
cadmium 10
silver 10
Deoxycoformycin 10
salt 10
Pac 10
Adriamycin 10
CO2 10
Busulfan 9
PPD 9
A 42 9
phenol 9
Praziquantel 9
Rapamycin 9
nitrate 9
Neo 9
PPD 9
A 3 9
glycerol 8
ITP 8
TAR 8
aniline 8
valine 8
SDS 8
PEG 8
GPT 8
CDA 7
A 71 7
DTPA 7
vitamin D 7
chromium 7
neopterin 7
methionine 7
serine 7
pyrimidine 7
pyrimidine 7
hydrogen 7
GTP 7
CCl4 7
A 1 7
Isoproterenol 7
ammonium 7
Prednisolone 7
pyridine 7
Bilirubin 7
chloroform 6
Chlorambucil 6
VP-16 6
ANCA 6
6-12 6
Adrenal 6
LCR 6
PEG 6
iodine 6
Chloroquine 6
uridine 6
PMA 6
Chloroquine 6
HCl 6
selenium 6
hyaluronic acid 6
DDT 6
Methotrexate 6
H2O2 5
isopropanol 5
MEK 5
AMP 5
methanol 5
bis(2-chloroethyl) 5
SET 5
2,3-diphosphoglycerate 5
Bantu 5
carbonate 5
ALP 5
barium 5
cAMP 5
ACTH 5
cobalt 5
pentose 5
Rifampicin 5
ADP 5
pentose 5
ADP 5
tryptophan 5
pentose 5
threonine 5
pentose 5
aspartic acid 5
ADP 5
aspartic acid 5
CdCl2 5
aspartic acid 5
Indomethacin 5
NKT 5
Lactate 5
ASA 5
cGMP 5
DDD 5
PMA 5
Ara-C 5
more...