Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038002 (splenomegaly)
 9,873 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Phenylhydrazine (PHZ) oxidation resulting in free iron release followed by free radical generation has increased frequency of cancer. This study aims towards the dose-dependent response of PHZ and the role of melatonin in comparison with vitamin E following PHZ-induced toxicity within the lymphoid tissue (spleen) of Indian tropical seasonal breeder, Funambulus pennanti, during reproductively active phase. An increase in the damages in terms of lipid peroxidation (LPO), apoptosis percentage, and splenomegaly was observed following different doses of PHZ treatment, i.e., 0.025, 0.5, and 1 mg/100 g body weight (b.wt.), where dose of 1 mg/100 g b.wt. showed more significant damages. Both melatonin (0.5 mg/100 g b.wt.) and vitamin E (1 mg/100 g b.wt.) administration ameliorated oxidative damages of 1 mg/100 g b.wt. PHZ-treated group. Melatonin altered PHZ-induced responses significantly to a greater degree than vitamin E as evidenced by LPO status, SOD activity, and ABTS radical cation scavenging activity of antioxidants. Thus, melatonin might be able to restrict carcinogenic property of PHZ-induced oxidative stress by protecting macromolecules of the cell from harmful effects of PHZ and instead preserving cell viability.
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PMID:Comparative effect of melatonin and vitamin E on phenylhydrazine-induced toxicity in the spleen of Funambulus pennanti. 1844 75

We analyzed the effect of natural solar insolation and artificial photoperiodic conditions on melatonin MT1 receptor expression of a tropical rodent, Funambulus pennanti. Melatonin mediates reproductive and circadian responses and regulates the production of a large number of cytokines, including interleukin-2 (IL-2), via modulation of MT1 receptor expression. Maximum pineal activity, resulting in high melatonin level, low melatonin receptor expression, and increased splenic mass, was noted in the winter months, while an opposite effect was noted during the summer months. Further, constant light exposure mimicked an "enhanced summer"-like condition with significant hyposplenia, and an opposite effect was observed with constant dark exposure with significant splenomegaly in F. pennanti. In the annual study, a slight increase in melatonin level was noted during the monsoon period, when the duration of photoperiod was the same but the amount of solar insolation and direct radiation decreased. The present study found that not only the duration of natural sunlight (i.e., photoperiod) but the intensity of sunlight expressed by solar insolation affects the circulatory level of melatonin and melatonin receptor expression in this wild tropical rodent. An increase in the circulatory level of melatonin induced a decrease in its receptor subtype MT1 expression in splenic cells, both at the transcriptional and translational levels, thus reflecting autoregulatory down-regulation of melatonin receptors. Therefore, in our animal model, F. pennanti melatonin may be suggested as a molecular messenger of photoperiodic signals (duration and intensity) directly acting via MT1 receptor regulation to adapt the immune system of animals residing in the tropical zone.
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PMID:Response of melatonin receptor MT1 in spleen of a tropical Indian rodent, Funambulus pennanti, to natural solar insolation and different photoperiodic conditions. 2003 May 40