Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0038002 (
splenomegaly
)
9,873
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
It is well documented that enhanced garlic (Allium sativum) consumption leads to decrease in the cancer incidences.
Diallyl sulfide
(
DAS
), one of the components of garlic, induces cytotoxicity and apoptosis in many cancer cell lines. The present studies are focused on the in vivo effects of
DAS
on leukemia WEHI-3 cells in the BALB/c mice. We examined the effects of
DAS
on the cytotoxicity of WEHI-3 cells and results indicated that
DAS
decreased the percentage of viable WEHI-3 cells and these effects are dose-dependent. We examined the effects of
DAS
on WEHI-3 in vivo and the results indicated that
DAS
decreased the percentage of Mac-3 and CD11b, indicating that the differentiation of the precursor of macrophage cells was inhibited.
DAS
stimulated the percentage of CD3 and CD19, indicating that the differentiation of the precursor of T and B cells promoted. The weights of liver and spleen indicated that
DAS
decreased the weight of these organs after being compared to the control groups. One of the major characteristic of WEHI-3 leukemia is the
enlarged spleen
in murine after intraperitoneal (i.p.) injection of WEHI-3 cells. In conclusion,
DAS
affects WEHI-3 cells both in vitro and in vivo.
...
PMID:Diallyl sulfide inhibits murine WEHI-3 leukemia cells in BALB/c mice in vitro and in vivo. 1985 Jun 53
