Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038002 (splenomegaly)
 9,873 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hyperreactive malarious splenomegaly (HMS) represents an abnormal immune response to recurrent malarial infection. In the Upper Watut Valley of Papua New Guinea, where over 80% of adult inhabitants are known to develop the disease, human leucocyte antigen (HLA) studies have demonstrated an association between the antigen DR2 and gross splenomegaly. To test the hypothesis that the magnitude of the individual immune response to malaria is also influenced by the number of different HLA antigens present, we have studied the correlation of the level of observed heterozygosity at HLA-A, -B, -C and -DR loci with the degree of splenomegaly in adult Watut subjects. Heterozygosity per se provides additional antigens for the formation of complexes between HLA and foreign antigenic epitopes, considered crucial to mounting an immune response. Multiply heterozygous individuals were found to exhibit more intense immune responses to recurrent malarial infections than did individuals with low multiple-locus heterozygosity. On the basis of the analysis presented here, we suggest that the degree of immune response to malaria is also influenced by the level of HLA heterozygosity, although the exact mechanisms remain unclear.
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PMID:HLA heterozygosity and hyperreactive malarious splenomegaly in the Upper Watut Valley of Papua New Guinea. 269 23

Tropical splenomegaly syndrome (TSS) develops as a result of an atypical immune response to recurrent malarial infection. In general a low prevalence disorder, in the Upper Watut Valley of New Guinea TSS affects more than 80% of the inhabitants. We have studied the association of antigens and haplotypes of HLA-A,B,C, DR, and DQ loci with the severity of TSS as judged by the degree of splenomegaly in 77 unrelated Watut. The study confirmed the previously observed lack of association of TSS with HLA-A and B locus antigens. By contrast, HLA-DR2 was found to be more frequent in patients with gross splenomegaly than in those with moderate splenic enlargement. No two-locus haplotypes were, however, found to be significantly associated with TSS.
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PMID:HLA and tropical splenomegaly syndrome in the Upper Watut Valley of Papua New Guinea. 392 41

20 patients of schistosomal hepatic fibrosis and splenomegaly (SHF) with and without haematemesis were examined. Typing for HLA-A, B and C antigens in these patients were compared with those of a group of 100 Egyptian controls. The study showed the presence of an association between HLA-A1 and B5 antigens in SHF cases. However, there was no significant association between HLA antigens and SHF cases with haematemesis.
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PMID:HLA antigens in schistosomal hepatic fibrosis patients with haematemesis. 393 92