Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0038002 (
splenomegaly
)
9,873
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Spleen plays an important role in removing old and damaged red blood cells and malaria-infected erythrocytes. When malaria parasites invade the spleen and induce
splenomegaly
, splenic function tends to be impaired. Thus, the inhibition of
splenomegaly
is strongly required to protect the spleen. In this study, malaria-induced
splenomegaly
is inhibited by injecting genistein into a Plasmodium berghei-infected ICR mouse. To explain this phenomenon, the effect of genistein in spleen and liver of malaria-infected mice was evaluated by histological examination. Malaria parasites disrupted splenic architecture. After treating genistein, the disrupted architecture in which red and white pulp regions were clearly separated in recovered to uninfected ones. Changes in biophysical properties of blood were studied by measuring the viscosity of blood collected from malaria-infected and uninfected mice using a microfluidic viscometer.
Genistein
also had a negligible influence on variation in blood viscosity. The enzymatic activity and expression pattern of proteins were then investigated to explain the genistein effect on malaria-induced
splenomegaly
.
Genistein
is a potential drug for
splenomegaly
in P. berghei-infected mouse.
...
PMID:In vivo study on splenomegaly inhibition by genistein in Plasmodium berghei-infected mice. 2600 68
Spleen traps malaria-infected red blood cells, thereby leading to
splenomegaly
.
Splenomegaly
induces impairment in splenic function, i.e., rupture. Therefore,
splenomegaly
inhibition is required to protect the spleen. In our previous study, genistein was found to have an influence on malaria-induced
splenomegaly
. However, the effect of genistein in malaria-induced
splenomegaly
, especially on the function of spleen, has not been fully investigated. In this study, hematoxylin and eosin (H&E) staining images show that genistein partially prevents malaria-induced architectural disruption of spleen. In addition, genistein decreases transgenic Plasmodium parasites accumulation in the spleen.
Genistein
treatment can protect splenic function from impairment caused by malaria infection. To examine the functions of malaria-infected spleen, we employed single-photon emission computed tomography/computed tomography (SPECT/CT) technology. Red blood cells are specifically radiolabeled with Technetium-99m pertechnetate (
99m
TcO
4
-
) and trapped inside the spleen. The standardized uptake values (SUVs) in the spleen of infected mice are higher than those of naive and genistein-treated mice. However, genistein reduces the malaria-induced trapping capacity of spleen for heat-damaged radiolabeled RBCs, while exhibiting a protective effect against malaria. Considering these results, we suggested that genistein could be effectively used in combination therapy for malaria-induced splenic impairment.
...
PMID:SPECT/CT analysis of splenic function in genistein-treated malaria-infected mice. 2758 99
