Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038002 (splenomegaly)
 9,873 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A comparative study of dengue hemorrhagic fever in infants and children was conducted at the Department of Pediatrics, Phetchabun Hospital between May,1999 and December, 2002. There were 1,924 DHF patients (aged 0-14 years). There were 40 (2.1%) infants (age 0-l years) and 27 (1.4%) young children (age 1-2 years). Sixty-seven cases (3.5%) of the older children (> 2-14 years) were selected to be compared. The clinical and epidemiological data for each of the three groups were not statistically different from each other, except for age, splenomegaly, shock state and mode of dengue infection. Older children were more likely to have a second dengue infection and a shock state than younger patients. Laboratory investigation results and fluid management for each of the three groups were not significantly different from each other except for the total WBC (min), neutrophils (max), lymphocytes (max) and platelets (min). The platelets (min) in the infants were significantly lower than in the younger children and the older children. Associated symptoms, diseases, complications, and hematologic manifestations in each of the three groups were not significantly different from each other except for the presence of coryza, seizures, nausea/vomiting, rash, and petichiae. Coryza, seizures, nausea/vomiting, rash, and petichiae in the infants and younger children were significantly different from the older children.
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PMID:DHF in infants, late infants and older children: a comparative study. 1629 42

The present work is a prospective, observational, hospital based study on 100 sero positive cases of dengue infection, admitted to Dhaka Children Hospital, Dhaka, Bangladesh during the period 2000 -2001. The patients were in the age group 8 months to 14 years with a mean age of 8.3 years. The serological tests were performed by rapid strip test. Primary dengue infection (only Ig M positive) was observed in 15% cases while rest 85% were secondary dengue infection (either Ig G or both Ig M and Ig G positive). Classical dengue fever (DF) was noted in 11% patients and 89% children presented with dengue hemorrhagic fever / dengue shock syndrome (DHF / DSS). Common clinical presentations were fever, headache, retro- orbital pain, arthralgia / bone pain, vomiting, abdominal pain and bleeding manifestations. Other presentations were tachycardia, bradycardia, hypotension, hepatomegaly, splenomegaly, pleural effusion, ascites, thrombocytopenia and high hematocrit values. The incidences of tachycardia, hypotension, hepatomegaly, high hematocrit and thrombocytopenia were significantly higher in DHF / DSS cases. The tourniquet test was positive in significantly higher percentage of DF cases. The tourniquet test and thrombocytopenia did not correlate well with other bleeding manifestations suggesting alternate pathogenesis for bleeding. In an epidemic setting, if a child presents with fever, vomiting, musculoskeletal pain and bleeding along with hepatomegaly, low platelet count and high hematocrit, a strong possibility of DHF/ DSS should be kept.
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PMID:Clinical and laboratory profile of dengue infection in children. 1860 66