Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0038002 (splenomegaly)
 9,873 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Administration of poly-4-vinylpyridine to mice in the maximal tolerance dose doubled the colony-forming units (CFU) and decreased the cell count by 22% in the bone marrow. The increase of CFU number takes place from 2 to 7 days. The cell count in the bone marrow began to decreased 2 hours after the administration of the polymer and remained below the initial level for 5 days; however it began to return to the normal from the second day, reaching the normal figures by the 7th day. In the spleen the CFU rose 9-fold, with a simultaneous development of splenomegaly on account of increased cell count.
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PMID:[Effect of poly-4-vinylpyridine on the quantity of colony-forming cells in the bone marrow and spleen of mice]. 87 Jan 13