Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038002 (splenomegaly)
 9,873 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cells and histocompatibility antigen systems involved in graft-versus-host reactions (GVHR) were analyzed using Simonsen's splenomegaly assay employing various combinations of donor and F1 hybrid recipients mice. Most of the cells proliferating in spleens of mice undergoing GVHR were J11d+, and had histological features of cells of the hematopoietic lineage. The proportions of CD3+ T cells were decreased in the spleens. Disparity at minor histocompatibility determinants of AKR, I-E and H-2D regions between B10.A(4R) donors and (4R X AKR) F1 recipients evoked only negligible GVHR. On the contrary, disparity at H-2K and/or I-A regions appeared to be sufficient to permit induction of full GVHR. When surface markers of donor spleen cells were analyzed, it was shown that Thy-1+ and/or MEL-14+ cells caused a strong effect on GVHR. Further, either CD4+ or CD8+ T cell subset could induce significant GVHR. However, synergistic influences of these two T cell subsets on one another in GVHR were observed. The present results raise the possibility of using Simonsen's assay along with a number of reagents to identify the contribution of subsets of T lymphocytes and in analyzing precise contributions of cellular components from both donor and recipient, and also of the target antigen systems of the recipient that contribute to early events involved in GVHR.
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PMID:A study on graft-versus-host reaction (GVHR) by Simonsen's splenomegaly assay. Cells and antigen systems involved in induction of GVHR. 278 42

The major histocompatibility locus in the chicken is the B locus with a minor histocompatibility antigen controlled by a gene (s) on the W chromosome. This study was designed to determine the quantitative effects of the B locus and the sex linked histocompatibility gene on splenomegaly of chick embryos after inoculation with adult male lymphocytes. The embryos and male lymphocyte donors had blood group genotypes designed B9/B9, B9/B11 so that nine donor-host combinations were used. When the donor and host were homozygous for different B alleles (B9 and B11) or different by one B allele (B9 or B11) the splenomegaly was 4 and 2 times greater, respectively, than the compatible donor and host. A greater splenomegaly was produced in male to female injections than in male to male injections. However, the histocompatibility antigen controlled by a gene(s) on the W chromosome was weaker than the controlled by the B locus.
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PMID:The quantitative effects of the B blood group locus and sex linked histocompatibility antigen in chickens on G-v-H reaction. 734 63

Spleen cells of female C57BL/6 mice, preimmunized to male histocompatibility antigen, elicited splenomegaly in adult male recipients and caused mortality of the newborn recipients. These cells, upon stimulation in vitro with the male antigen, were cytotoxic to male target cells.
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PMID:Graft-versus-host reactions against H-Y antigen. 737 69