Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0038002 (splenomegaly)
 9,873 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 32-year-old homosexual with AIDS, who until 1985 was a frequent traveller to South America and mediterranean countries, had recurrent bouts of fever, splenomegaly, arthralgias as well as granulocytopenia and anaemia. Liver and bone-marrow punctures were performed to exclude malignant lymphoma and (or) a mycobacterial infection. Both biopsies revealed Leishmania donovani. During administration of sodium stibogluconate (Pentostam) the fever disappeared for a time and there was clinical improvement, but further treatment was limited because of thrombocytopenia. In patients with AIDS who have splenomegaly with nonspecific fever, visceral leishmaniasis must be considered in the differential diagnosis even outside of endemic regions.
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PMID:[Visceral leishmaniasis (kala-azar) in acquired immunodeficiency syndrome (AIDS)]. 284 75

The case report is presented of a 18-year old patient, who was admitted to the Haematology Department of the Hanusch Hospital with septic fever, an enlarged spleen and suspected bone marrow failure. Since the patient reported a stay in Sicily prior to the onset of his disease, an infection with Leishmania was suspected. The serological test was highly positive and Leishmania was also isolated from the spleen aspirate. Chemotherapy with Pentostam was successful and the patient made an uneventful recovery. This paper deals with the epidemiology of the disease and discusses the diagnostic approaches.
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PMID:[A rare cause of septic syndrome]. 298 47