Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038002 (splenomegaly)
 9,873 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We present a six-year follow-up of a boy with a novel type of hypolipoproteinemia, with clinical and biochemical features distinct from classical hypoalphalipoproteinemias. There were abnormally low concentrations of total and high-density lipoprotein (HDL) cholesterol, apolipoprotein (apo) B, apo A-I, and apo A-II, and the phospholipids were decreased. The most striking abnormality was an extra fraction containing mainly phospholipids and apo A-I in the HDL3 subfraction. This fraction is reminiscent of concentric 20- to 50-nm-diameter lamellar phospholipid liposomes. Plasma lecithin:cholesterol acyltransferase activity was strongly decreased. We noted a persisting polyclonal hypergammaglobulinemia, hematological abnormalities (hemolytic anemia and thrombocytopenia), and a progressive splenomegaly. After the five-year follow-up, the patient had recurrent severe infections; moderate hematuria and proteinuria developed gradually. Treatment with corticosteroids and immunoglobulins improved thrombocytopenia and hypolipoproteinemia. These clinical and biochemical findings differ from those in the known primary and secondary hypo-alpha-lipoproteinemia syndromes. Although investigation of the relatives suggests a familial predisposition for hypo-alpha-lipoproteinemia, the subject's condition can be regarded as acquired.
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PMID:Acquired hypolipoproteinemia. 158 35

A random sample of 125 woodworkers in Ivory Coast was subjected to a biological health check-up. Being relatively simple this check-up has allowed us however to reveal the following pathological states for subjects not complaining of any illness: 2 anemia, 25 haemoglobinopathies, I monoclonal dysglobulinemia, I massive dysglobulinemia with splenomegaly, 8 massive hypergammaglobulinemia. Otherwise the following frequent values gave been determined according to RICHTERICH's statistical approach: age, height, weight, hematocrite haemoglobinemia, haemoglobin type, proteinemia, lipidemia, cholesterolemia, triglyceridemia, alpha-lipoproteinemia, A. M. G. immunoglobulinemia.
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PMID:[Biological health check-up for woodworkers in Ivory Coast: first results (author's transl)]. 627 28