Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0038002 (
splenomegaly
)
9,873
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The haemolytic process in hepatosplenic schistosomiasis is often regarded as a result of
splenomegaly
that can be increased by spontaneous or surgical shunts. The importance of
splenomegaly
and/or shunt on the etiology of haemolysis was studied in a group of 74 patients with hepatosplenic schistosomiasis and portal hypertension. They were divided into 4 groups: Group I (22 cases) - pre-operative; Group II (15 cases) - classic splenorenal shunt; Group III (22 cases) - selective portal decompression and Group IV (15 cases) - azygoportal disconnection with splenectomy. The first group is characterized by the presence of
splenomegaly
and the absence of shunt; the second by the presence of shunt and absence of
splenomegaly
; the third, by the presence of both
splenomegaly
and shunt and the last by absence of both, shunt and
splenomegaly
. In all cases, the levels of sensitive markers of haemolysis, such as haptoglobin and
hemopexin
as well as non-conjugated and total bilirubins were determined. Biochemical and coagulation parameters, used to evaluate the hepatic function, were also studied. The data was initially analysed according to a factorial experiment of 2 and standard least squares techniques were used to evaluate the effects of
splenomegaly
, shunt and their interaction. The results showed that the shunts always provoked haemolysis, even in the absence of
splenomegaly
, but the presence of both,
splenomegaly
and shunt, always increased the process of haemolysis.
...
PMID:Systemic surgical shunts and splenomegaly as causes of haemolysis in portal hypertension in mansonic schistosomiasis. Evaluation through serum levels of haptoglobin, hemopexin and bilirubins. 308 93
Intravascular hemolysis is associated with several pathologic conditions that include hemoglobinopathies, trauma, malaria, and bacterial infections. Among plasma-protective proteins against oxidative damage caused by red blood cell rupture, haptoglobin and
hemopexin
are thought to play a crucial role. Haptoglobin and
hemopexin
, by binding with high-affinity hemoglobin and heme, respectively, exert an antioxidant action by preventing heme-catalyzed free radical production. Moreover, these proteins prevent iron loss by inhibiting glomerular filtration of hemoglobin and heme diffusion through plasma membranes. Analysis of single-null mice demonstrated the antioxidant action of haptoglobin and
hemopexin
in vivo and suggests that the 2 proteins cooperate in the resolution of hemolytic stress. To evaluate the physiological relevance of the haptoglobin-
hemopexin
system and the principal targets of its action, we generated haptoglobin-
hemopexin
double-knockout mice and analyzed them under basal conditions and after acute hemolysis. Whereas haptoglobin-
hemopexin
double-null mice displayed no obvious alteration in phenotype under basal conditions, nonlethal hemolytic stress in these animals led to pronounced
splenomegaly
as well as liver inflammation and fibrosis. These data demonstrate that haptoglobin and
hemopexin
together are essential for protection from
splenomegaly
and liver fibrosis resulting from intravascular hemolysis.
...
PMID:Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis. 1239 71
