Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038002 (splenomegaly)
 9,873 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During the 9-year period 1968-76 116 splenectomies were performed at the General Hospital, Nottingham. Of these, 13 (11 per cent) were undertaken for unexplained splenomegaly. In 6 patients a diagnosis was established by the operative procedure (2 with sarcoidosis, 2 splenic cysts, 1 Gaucher's disease and 1 haemangiosarcoma). Histological examination of the excised spleens in the remaining 7 patients showed no specific features. Two of these patients benefited considerably from removal of very large spleens. Another patient died from lymphosarcoma which was diagnosed 21 months after splenectomy. In the remaining 4 patients with mild to moderate splenomegaly, there were no real diagnostic or therapeutic advantages. It is concluded that splenectomy should always be considered in patients with unexplained moderate or gross splenomegaly but it may not be helpful in the patient whose spleen is only midly enlarged.
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PMID:Splenectomy for undiagnosed splenomegaly. 42 Sep 76

Twenty-two patients with lymphocytosis and sometimes accompanied by splenomegaly selected from our difficult diagnostic cases over the past two years are presented. The clinical and laboratory features pointed to one of the following: chronic lymphatic leukaemia without lymphadenopathy, lymphosarcoma or other lymphoreticular tumour, tropical splenomegaly syndrome with a lymphatic leukaemoid reaction. The precise diagnosis was usually made by haemotological laboratory tests - viz. (a) Lymphocytes transformation test (LTT) (b) Serum/Plasma IgM estimation. It was found that: (1) There was markedly raised IgM in the responders i.e. patients with Tropical Splenomegaly Syndrome (TSS) whose spleens regressed following treatment with antimalarials, contrasting the normal levels of IgM in the non-responders to antimalarial therapy. (2) The PHA - Lymphocytes Transformation in the TSS was normal while that of Chronic Lymphatic Leukaemia (CLL) was abnormally low. These combined tests (LTT & IgM) are recommended as investigations for leukaemoid reactions involving lymphocytes.
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PMID:The use of lymphocyte transformation and IgM estimation as diagnostic aids in leukaemoid reactions. 52 52

Foam cells in the spleen, bone marrow, liver and lymph nodes were examined on the 73 reliably recorded and sampled leukemia autopsy cases encountered at Kobe University from 1958 to 1972. Although the substances stored in the foam cells were biochemically unknown, the foam cells in leukemia could be morphologically classified into two types: The one was identified with the Gaucher type, but the other was not identified with the sea-blue type and might be considered as to be the transitional type described in another report. Foam cells could be found in the spleen of 6 out of 12 cases of chronic myeloid leukemia, one out of 2 cases of chronic lymphatic leukemia, one out of 7 cases of leukemic lymphosarcoma, one out of 9 cases of acute lymphatic leukemia, and none in 3 cases of monocytic leukemia. In acute myeloid leukemia, the incidence of foam cells in the spleen was 47.5% in 40 cases, and acquired lipidoses were more frequently seen in cases under 19 years of age, in male cases, in cases with an enlarged spleen over 400 g, and in cases of over 4 months' duration.
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PMID:Secondary lipidosis in leukemia. 99 40

A 56-year-old male was admitted to our hospital with lymphocytosis (16.4 x 10(9)/l; 79% lymphocytes including 50% small lymphocytes), generalized lymphadenopathy, massive splenomegaly, and heavily infiltrated bone marrow. Immunophenotype analysis of the neoplastic cells in the bone marrow revealed that they were B cells (CD20 + CD19 + Ia1 + sIgM+) positive for CD10. By contrast, the cells in the lymph node were CD20 + CD19 + Ia1 + sIgM+ but negative for CD10. The patient was tentatively diagnosed as having lymphosarcoma cell lymphoma, however, the final diagnosis was leukemic phase of intermediate lymphocytic lymphoma. We concluded that CD10+ neoplastic cells in the bone marrow and peripheral blood had differentiated to CD10- cells.
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PMID:Leukemic phase of intermediate non-Hodgkin's lymphoma with cells showing different matured stages in invaded various organs. 138 93

Different types of lymphoid malignancy were observed in two sheep inoculated with BLV-containing materials. Sheep 1 showed severe leukemic change in the peripheral blood and splenomegaly but lymphosarcoma in the lymph nodes was absent. Sheep 2 had lymphosarcoma in the lymph nodes and various organs. Neoplastic cells had B-cell marker in both cases and a few neoplastic cells contained intracytoplasmic IgM in sheep 2. It was presumed that B-cells might be transformed into neoplastic cells on the way of their differentiation. Some of neoplastic cells might have ability of immunoglobulin-production in sheep 2.
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PMID:Pathological findings of two types of lymphoid malignancy in sheep inoculated with bovine leukemia virus. 255 19

Results from transabdominal fine-needle aspiration of the spleen in 28 dogs and 5 cats are reported. Splenomegaly was present in 79% of these patients, and splenic masses were present in 15%. Extramedullary hematopoiesis, the most common cytologic diagnosis, was found in 24% of the patients and was associated with a variety of diseases including immune hemolytic anemia, hemangiosarcoma, and bone marrow hypoplasia. Hematopoietic neoplasms including lymphosarcoma, plasmacytoma, myelogenous leukemia, and systemic mastocytosis were diagnosed in 24% of the patients. Other diagnoses included malignant neoplasia of undetermined cell type and lymphoreticular hyperplasia. Splenic aspirates were considered normal in 18% of the animals. Two (6%) of the aspirates contained liver tissue rather than spleen. Histologic evaluation of splenic tissue was performed in 42.5% of the patients. All cytologic diagnoses correlated well with their final histologic diagnoses. Complications from the aspiration procedure were not observed, even in thrombocytopenic patients.
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PMID:Fine-needle aspiration of the spleen as an aid in the diagnosis of splenomegaly. 350 95

Transplantable strain of murine lymphosarcoma growing as a free suspension in the peritoneal cavity of isologous hosts was continuously irradiated by 60Co unit at a low exposure rate of 1.2 Gy/day for 350 weeks. Long-term irradiation did not alter substantially the viability and invasiveness of tumor cells. In the host of irradiated cells the spleen mass was six times higher around the day 8. Histological sections of the spleen revealed areas of edema and hemorrhage and infiltration and proliferation of tumor cells mostly in subcapsular area. Most of the splenomegaly is considered to be due to hyperemia caused by mass of erythrocytes in dilated spleen sinuses. Continuous irradiation is supposed to lead to more pronounced sarcomatous character of LS/B1 tumor.
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PMID:The growth and dissemination of continuously irradiated LS/B1 lymphosarcoma cells. 654 11

Thoracic and abdominal radiographs from 100 dogs with lymphosarcoma were reviewed to determine the type and frequency of radiographic abnormalities associated with the disease. Sternal lymphadenopathy was the most frequent (60%) thoracic radiographic abnormality. Hepatomegaly (47%), splenomegaly (55%), and sublumbar lymphadenopathy (49.5%) were the most frequent abdominal radiographic abnormalities; these were most often seen in combination. A single radiographic abnormality or combination of abnormalities was not observed frequently enough to suggest that a diagnosis could be made only on the basis of radiographic findings.
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PMID:Thoracic and abdominal radiographic abnormalities in the multicentric form of lymphosarcoma in dogs. 689 27

Lymphosarcoma is described in a wild juvenile harbor seal (Phoca vitulina richardii). Gross lesions included hepatomegaly, splenomegaly and lymphadenopathy. Neoplastic lymphoid cells were observed histologically in lung, kidney, liver, spleen, adrenals, bone marrow and visceral and peripheral lymph nodes.
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PMID:Lymphosarcoma in a harbor seal (Phoca vitulina richardii). 689 10

221 patients were treated by splenectomy for various hematologic disorders, including immunologic thrombocytopenia (80 cases), hereditary spherocytosis (15 cases), immune hemolytic anemia (25 cases), chronic lymphatic leukemia (27 cases), lymphosarcoma (27 cases), myelofibrosis (11 cases) and pancytopenia/aplastic anemia (14 cases). There were 8 postoperative deaths (3.6%), and 49 patients (22%) had postoperative complications, mainly infections and bleeding. Complications were more frequent in cases of massive splenomegaly (greater than or equal to 1 000 g) (65 cases), severe thrombocytopenia (less than 20 X 10(6)/1) (51 cases), and leukemia. Late postsplenectomy fulminant infection was seen in 8 patients (3.6%) for a mean follow up of 5.3 years. We conclude that splenectomy is sufficiently well tolerated even by severely ill patients to make it applicable as a therapeutic modality in the various hematologic disorders presently studied.
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PMID:Complications after therapeutic splenectomy for hematologic disease in adults. 722 97


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