Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038002 (splenomegaly)
 9,873 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Clinical and laboratory parameters investigated in pseudotuberculosis patients with and without CO proved patients with mixed infection to be more seriously affected. They had more pronounced polymorphism of clinical symptoms, more severe intoxication, fever, hepato- and splenomegaly, longer convalescence, more frequent relapses, worse laboratory findings. Complicated course of pseudotuberculosis patients with CO may be due to hypersensitization of the body and hepatobiliary disorders resultant from parasitic invasion.
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PMID:[The clinico-laboratory characteristics of pseudotuberculosis in persons with chronic opisthorchiasis]. 790 7

During the last fourty years the "hare type" of Yersinia enterocolitica was detected in the brown hare and other mammals in several European countries. In northern Germany (Province of Schleswig-Holstein) the pathogen was not found in the post mortem materials of the cattle, swine and horses during the years 1990-1996. In approximately 1,000 sheep studied this yersinia was cultured from the internal organs of one diarrhoeic lamb. The examination of some 200 perished hares reveals one animal with granulomatous splenomegaly and culture of this pathogen. Yersinia enterocolitica is one of the pathogens causing pseudotuberculosis-like lesions in the hare.
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PMID:[Yersinia enterocolitica serovar 2a, wb, 3:b,c biovar 5 in hares and sheep]. 929 39

An outbreak of Yersinia pseudotuberculosis (Yptb) occurred in a closed colony of Egyptian fruit bats (Rousettus aegyptiacus) and resulted in the death of seven bats over a 6-week period. An initial survey of the remaining bats revealed visceral abscessation characteristic of pseudotuberculosis in five of the 12 bats examined (41.7%), inciting depopulation of the colony. At necropsy, 70% of the 115 bats in the colony exhibited gross evidence suggestive of Yptb infection, including mesenteric lymphadenopathy (ML), hepatic abscessation (HA), and/or splenomegaly (SPM). Thirty of these bats (13 females and 17 males of various ages) were chosen at random and their tissues submitted for bacterial culture and histopathologic examination. Twenty-three of these 30 bats had one or more gross lesions considered consistent with Yptb, including ML, HA, and SPM. On histopathology, four of the 30 bats had necrotizing lesions containing Gram-negative bacteria in multiple organs, while 18 others exhibited mild mesenteric lymphadenitis and hepatitis. Four of the 30 bats had positive cultures for Yptb. Bats with gross evidence of mesenteric lymphadenopathy, splenomegaly, or histopathologic presence of demodicosis or bacteria in tissues were more likely (P < 0.05) to have a positive Yersinia culture. Examination of the correlation between population density and mortality rates of the colony revealed that the mortality rate of subadult bats increased dramatically at the time of the outbreak, when the population density was at its highest. It is suspected that stress, primarily from severe overcrowding, predisposed the bat colony to morbidity and mortality from this organism, which likely originated from a rodent reservoir.
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PMID:Yersinia pseudotuberculosis in a closed colony of Egyptian fruit bats (Rousettus aegyptiacus). 1936 35