Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0038002 (splenomegaly)
 9,873 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Upper gastrointestinal hemorrhage secondary to splenic vein thrombosis is a curable form of localized portal hypertension when treated with splenectomy. A high index of suspicion is necessary in order to promptly diagnose and treat this underrecognized condition that is most commonly caused by inflammation or neoplasm of the pancreas. The triad of isolated gastric varices, splenomegaly, and normal hepatic function is classic; it is not uncommon, however, for patients to have only some or even none of these conditions. Mesenteric angiography with venous phase imaging is the gold standard of diagnosis. Ultrasound and CT may identify splenic vein thrombosis, but are most helpful in delineating concomitant upper abdominal pathology. Early recognition and intervention allow associated underlying conditions to be treated under the same anesthetic with minimal morbidity and mortality.
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PMID:The clinical complexity of splenic vein thrombosis. 961 78

A combined experience of 37 cases of subacute hepatic failure encountered in five major gastroenterology centres over a period of ten years is discussed. Majority (65%) were males with average age of 38 years. Maximum (54%) were in 5th decade. Jaundice (100%), abdominal distention (38.7%), swelling feet (64%), fever (54%), abdominal pain (54%), exhaustion (78.3%) were the major presenting features. Jaundice and ascites were present in all cases. Pedal oedema (78.3%), hepatomegaly (54%), splenomegaly (32.4%) and encephalopathy (27%) were the other important clinical features. Hypoalbuminemia and prolonged prothrombin time were significant laboratory findings in addition to hyperbilirubinemia and elevated ALT and AST. Hbs Ag was detected in 46%. Major complications encountered were renal failure (48.7%), spontaneous bacterial peritonitis (43.2%), other infections (43.2%), encephalopathy (43.2%) and upper gastrointestinal bleed (22%). 54% died during stay in hospital. To conclude subacute hepatic failure is potentially fatal condition.
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PMID:SUBACUTE HEPATIC FAILURE-A CLINICAL PROFILE. 2877 25

Left renal vein (LRV) has been considered as the most suitable vein for proximal splenorenal shunt (PSRS), a commonly performed shunt for non-cirrhotic portal hypertension. Anatomical anomalies in LRV that can pose technical difficulty during shunt procedure are reported in 10% cases. We report a rare anomaly of LRV which precluded performance of standard end-to-side proximal splenorenal shunt and describe its management by performing an interposition end-to-end proximal splenorenal shunt. A 50-year-old female presented with recurrent episodes of upper gastrointestinal bleed for five years. She was pale and had a massive splenomegaly. There were no signs of encephalopathy. Upper gastrointestinal (UGI) endoscopy revealed three columns of grade 3 esophageal varices, large fundal varices and mild portal hypertensive gastropathy. Duplex ultrasound and contrast-enhanced computed tomography (CECT) of the abdomen was suggestive of non-cirrhotic portal fibrosis. She underwent an interposition end-to-end proximal splenorenal shunt with inferior branch of left renal vein. She developed partial shunt thrombosis at follow-up of 18 months and underwent balloon angioplasty and metallic stenting of shunt. She is doing well at 24 months follow-up with no recurrence of symptoms and a patent shunt. In conclusion, the presence of renal vein abnormalities does not preclude performance of PSRS with suitable modifications. A high index of suspicion is required to detect them preoperatively to avoid technical difficulties and to plan modifications of PSRS. Interposition end-to-end graft proximal splenorenal shunt is a valid option with good primary-assisted patency rate and clinical outcome.
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PMID:Proximal Splenorenal Shunt in a Rare Renal Vein Anomaly: A Case Report. 3136 36

Portal hypertension is a clinical syndrome characterized by splenomegaly, with or without hypersplenism, and esphagogastric varices. Non-cirrhotic portal hypertension (NCPH) belongs to the presinusoidal sub category of portal hypertension. We present the case of a young 35-year-old male who had presented with two episodes of upper gastrointestinal bleed. On endoscopy, he was found to have large esophageal varices. On general physical examination, there were diffuse hyperpigmented papules and nodules all over the body, with palmoplantar thickening. His liver function tests were normal. Computed tomography of the abdomen showed a dilated portal and splenic vein with splenomegaly and normal liver size and histopathology showed non-cirrhotic portal fibrosis (NCPF). He had history of intake of oral indigenous medications for skin lesions. On investigating, patient was found to have chronic arsenicosis, which was likely the underlying etiology for NCPF as well. Hence, while evaluating patients of NCPF, it is imperative to rule out the use of indigenous medications, especially in the Indian scenario.
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PMID:Clue to the cause of portal hypertension: Look at the raindrops. 3228 Jul 85