Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0038002 (splenomegaly)
 9,873 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Over a period of 9 years in general practice temporary enlargement of the spleen was found in 29 episodes of pharyngitis or tonsillitis, in 2 episodes of acute upper respiratory tract infection other than pharyngitis and in 6 episodes of acute cervical lymphadenitis. In five patients more than one episode of illness associated with splenomegaly was recorded. In 26 of the 37 episodes a possible aetiology was identified. Evidence only of infection with group A streptococci was found in 14 episodes, adenoviruses or coxsackie B viruses were isolated alone in 4 episodes and in 4 episodes the only finding was the presence in the blood of more than occasional atypical mononuclear cells; in 4 episodes there was evidence of both streptococcal and viral infection. Episodes with evidence of streptococcal infection only tended to be of shorter duration and to be more evenly distributed over the year than were episodes without such evidence. Temporary splenomegaly was noted also in two children with varicella (one of whom also had streptococcal infection) and in an adult with probable rubella.
 ...
PMID:Splenomegaly in acute infections due to group A streptococci and viruses. 139 11

Twenty-four cases of purpura of the urinary tract are discussed and analysed.Purpura of the kidney may be a cause of painless haematuria. In some cases nephrectomy may be necessary to check the bleeding.Purpura of the bladder is a cause of painful haematuria. In such cases the diagnosis can be made with the cytoscope.A number of the cases appear to be caused by a streptococcal infection of throat, teeth or bowel.The exhibition of horse serum by the mouth usually has an immediate effect in checking the bleeding tendencySplenectomy should be considered in severe chronic recurrent cases.Purpura is a symptom and not a disease. It can attack the kidney or bladder in any type of case. The attacks may be simple, recurrent or fulminating. In many cases no cause can be discovered, in others it is associated with acute rheumatism. In a number of cases a proximate cause can be discovered, in the nature of a bacterial infection, a chemical poison, a thrombocytopenia, splenomegaly, or the deprivation of some vitamin.
 ...
PMID:President's Address: Purpura of the Urinary Tract. 1998 73