Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038002 (splenomegaly)
 9,873 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Serial blood-xylose concentrations have been determined in 28 Papua New Guineans after 25 g oral xylose; 9 had an acute and 8 a chronic systemic infection, 4 the tropical splenomegaly syndrome and 7 were free of infection. Mean xylose was significantly depressed at 30, 60, 90 and 120 min in those with acute and chronic infections. Correlations between xylose and serum albumin, alpha 1, alpha 2, beta- and gamma-globulin concentrations were not significant. When the xylose test is used in tropical countries the effect of systemic infections on the result must be careful evaluated, otherwise tropical malabsorption ('tropical sprue') might be diagnosed erroneously.
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PMID:Influence of systemic infections on xylose absorption. 611 56

Celiac Disease (CD), also known as non-Tropical sprue, and Celiac sprue is an immune-mediated disorder, triggered by gluten containing grains in genetically susceptible people. The disease may be diagnosed at any age and can affect many organ systems. Its diagnosis and management can often be challenging. A high index of suspicion is required to diagnose this disease at an early stage in patients presenting with atypical symptomatology and delayed onset. Although serological tests are widely used, duodenal biopsy remains the gold standard for diagnosis of CD. Even though CD affects various body systems, Microscopic Colitis (MC) and refractory sprue are among the main gastrointestinal complications of CD, which are resistant to Gluten-Free Diet (GFD). A thorough and appropriate evaluation is mandatory for an early and accurate diagnosis of these complications. Herein, we report a case of a young female with CD in early phase in concordance with MC and splenomegaly.
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PMID:Early, non-refractory celiac disease associated with microscopic colitis and splenomegaly. 2593 49