Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0038002 (splenomegaly)
 9,873 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Adult T-cell leukemia/lymphoma (ATLL) is an HTLV-I associated lymphoid malignancy frequently seen in Japan. Abdominal involvement in 40 patients with ATLL were assessed by ultrasonography and the findings seen in four clinical types, acute, chronic, lymphoma and smoldering, were compared. Splenomegaly was frequently found in the cases of acute and lymphoma types, and the sizes of the spleens measured by ultrasonography correlated well with the disease activity. Hepatomegaly was also found more frequently in acute and lymphoma types, and hepatosplenomegaly was proved to be due to the infiltration by ATL cells. Nodular lesions in spleen and liver and abdominal lymph node swelling were also found frequently in the lymphoma type but rarely in the other types. Ascites, pleural effusion, and pericardial effusion were found in the active stage of acute and lymphoma types. Ultransonography also could detect findings associated with therapies. Thus, ultrasonography studies were found to be very useful for assessing the clinical classification, examining various pathological conditions associated with ATLL, and monitoring the disease activity.
 ...
PMID:Assessment of abdominal involvement of adult T-cell leukemia/lymphoma by ultrasonography: comparison among four clinical types. 165 79

There is an increased frequency of disseminated tuberculosis in patients with acquired immunodeficiency syndrome (AIDS). The authors reviewed 6 thoracic and 10 abdominal computed tomography scans from 11 patients who had AIDS and disseminated tuberculosis. All scans demonstrated multiple, large, mediastinal or retroperitoneal lymph nodes, or both; low-density centers within enlarged nodes were identified in seven patients (63%). The scans also showed a diffuse miliary pattern (three patients), pericardial effusion (three patients), mild hepatomegaly (six patients), moderate splenomegaly (seven patients), hypodense splenic lesions (one patient), peritoneal fluid (four patients), bowel involvement (two patients) and dilatation of the biliary tract (two patients). Infection with Mycobacterium tuberculosis was demonstrated in all cases. The findings of this study show that lymph-node enlargement and nodes with low-density centers in patients who have AIDS are suggestive of disseminated tuberculous infection.
 ...
PMID:Disseminated lymphatic tuberculosis in acquired immunodeficiency syndrome: computed tomography findings. 225 9

A 29-year-old man had a febrile illness accompanied by chest pain and tachycardia. The ECG suggested either myocarditis or acute ischemia. Heart muscle enzymes were normal, the peripheral blood count showed absolute and relative lymphocytosis, and an echocardiogram disclosed a small pericardial effusion. After defervescence, splenomegaly was noted and the SGPT level was elevated to four times normal. There was a greater than fourfold rise in titer of IgM antibodies to cytomegalovirus. This is only the second report in detail of perimyocarditis caused by cytomegalovirus mononucleosis. An interesting aspect of the case was an afebrile prodrome that lasted for more than one week, during which prostration, palpitations, and breathlessness on exertion were present and the sole physical finding was tachycardia.
 ...
PMID:Perimyocarditis. Report on an unusual cause. 253 10

In addition to intrathoracic great vessel abnormality, pericardial effusion, and splenomegaly, extracardiac intrathoracic abnormalities were found in 12 of 210 patients' 99mTc red blood cell (RBC) gated cardiac blood pool imagings. These abnormalities, including five cases of absent pulmonary perfusion due to tumor mass, four of pleural effusion, two of pneumothorax, and one of left lung mass attenuation, were confirmed with concurrent or subsequent chest radiography, chest CTs, or biopsy. Pulmonary blood pool activity is normally seen on both sides in both anterior and left anterior oblique views; decreased or absent perfusion on either side or in part of the lung may indicate chest/pulmonary pathologies. Although pulmonary and thoracic wall lesions are not frequently seen, such incidental findings during gated cardiac blood pool imagings can lead to further study for these clinically unsuspected lesions and may benefit the patient.
 ...
PMID:Extracardiac intrathoracic abnormalities demonstrated by Tc-99m RBC gated blood pool imaging. 256 Dec 15

Mother, father (26 y.o.) and their only child (5 y.o.) developed nonproductive cough, fever (39.5 to 40.4 degrees C) and bilateral pulmonary infiltrates within three weeks. In addition the mother developed a small left pleural effusion and a pericardial effusion, a relative bradycardia, a pruritic vesicular exanthem of the extremities and the trunk, an erythema nodosum and arthritis of the tarsal joints. The father's coulter counter red blood count was distorted by microagglutination at room temperature (hemoglobin 13.2 gr/dl; erythrocytes 1,91 X 10(6) mm-3 and MCH 69.1 pg; MCV 120 fl and hematocrit 23.8%) but not at 37 degrees C (13.2; 4.15 and 31.8; 92 and 39.3, respectively). In the daughter myringitis, pharyngitis, cervical lymphadenopathy and splenomegaly were observed. Cold agglutinins and serologic evidence for mycoplasma pneumoniae infection were demonstrable in all three. Treatment with Tetracycline (parents) and Erythromycin (child) was effective.
 ...
PMID:[Familial Mycoplasma pneumonia. The varied picture of pulmonary and extrapulmonary manifestations]. 311 25

Subcostal echocardiography in patients with tense ascites can reveal an echo-free space anterior to the heart which could be mistaken for a loculated anterior pericardial effusion or a pericardial cyst. The ascitic nature of the space can be recognized by the contours of the space, its relationship to the liver, and to the distinctive midline appearance of the falciform ligament of the peritoneum bisecting the space. Less frequently ascitic fluid inferior to the left ventricle, between it and an enlarged spleen, can mimic a posterior pericardial effusion, on M-mode and even long-axis 2-D echography, but the ascitic nature of the space is evident on the short-axis 2-D view.
 ...
PMID:Echocardiographic simulation of pericardial effusion by ascites. 669 Feb 58

A 64-year-old man was admitted with complaints of lethargy, malaise, weight loss and transient left-hemiplegia and aphasia. Initial physical and laboratory findings showed splenomegaly and pericardial effusion. During his hospital stay, his mental status deteriorated progressively. The characteristic pathology of malignant reticulosis was noted at autopsy. Microscopic examination of the brain demonstrated accumulations of malignant histiocytic cells confined within small vessels and subsequent multiple hemorrhages and necroses in the gray matter. Malignant reticulosis with antemortem manifestations of pericardial effusion and central nervous system involvement is rare.
 ...
PMID:[A case of malignant reticulosis with pericardial effusion and central nervous system involvement]. 685 69

A case of acute monoblastic leukemia in a 68-year-old man is reported in which one of the presenting manifestations was a pericardial effusion. A blood-stained fluid was removed from the pericardium. The pericardial fluid showed blast cells on microscopical examination. The patient was treated with 6-Mercaptopurine and Methotrexate and achieved a short partial remission. He died of general infection, 4 months after the start of his illness. We found in the medical literature 30 additional cases with a mean age of 24 +/- 16 years and a striking male predominance (68. p. 100). We found 15 acute lymphoid leukemias, 9 acute myeloid leukemias, 4 acute indifferentiated leukemias, and 2 acute nontyped leukemias. The leukemic pericardial involvement is often associated with splenomegaly, adenopathy and pleural effusion. The management procedures include pericardiocentesis, general of local chemotherapy, irradiation of the cardiac area. The prognosis is generally poor, with a mean survival of 5 months.
 ...
PMID:[Pericarditis as the presenting manifestation of acute monoblastic leukemia-Report of a case and review of the literature (author's transl)]. 693 4

The investigations were carried out in 51 patients with different cardiovascular diseases using a gamma camera coupled to a computer. Pyrophosphate (Sn) injection followed by technetium-99m injection were administered through only one puncture of an antecubital vein. Tc-99m was given as a bolus and its passage through the cardiac cavities was recorded and ejection fraction and wall motion of left ventricle were estimated. It was observed that 10-30 min after Tc-99m injection a steady activity Tc-99m-labeled RBCs was maintained in the vascular bed which made possible evaluation of the motility of cardiac walls by the gating technique. Presence of labeled RBCs also permitted blood pool scans and spleen scans to be obtained. Cases investigated by this method for pericardial effusion and splenomegaly are described for illustration.
 ...
PMID:Cardiac studies using red blood cells labeled with Tc-99m in vivo with single intravenous injections--first pass technique, gating and blood pool scanning. 737 9

The detailed features of right sided endomyocardial fibrosis are described in 15 out of 10,000 consecutive patients who all had infection with Schistosoma mansoni and came from rural Egypt. Laboratory investigations, 12 lead electrocardiography, chest radiography, and Doppler echocardiography were performed in all patients. Cardiac catheterisation and angiography were performed in eight. Endomyocardial biopsy specimens were obtained from the right ventricles of two patients and pericardial biopsy specimens from two. Pericardiocentesis was performed in all patients. All patients were infected with S mansoni and had schistosomal hepatic fibrosis and ascites. Eleven had splenomegaly. All patients had raised cervical venous pressure with prominent Y descent and atrial fibrillation. Eosinophilia was notably absent. Echocardiography showed apical fibrosis in the right ventricle, obliteration of the ventricle, and moderate to massive exudative pericardial effusion in all patients. Calcification and fibrosis extended into the right ventricular outflow tracts in two patients. Huge right atrial thrombi occurred in five patients. Tricuspid regurgitation (grades I-II) was detected in 11 patients by Doppler ultrasonography. Haemodynamic and angiographic data confirmed the pure right sided restrictive pathophysiology. Pericardial biopsy specimens showed perivascular inflammatory infiltrates in two patients and a schistosomal granuloma in one. Endocardial biopsy specimens showed dense fibrosis with many fibroblasts. Endomyocardial fibrosis in Egypt is unique in several aspects. It always affected only the right side of the heart. Calcification and fibrosis extended to the right ventricular outflow tract. Pericardial inflammatory reaction was present. The relation to schistosomiasis and the link to periportal hepatic fibrosis in these patients is intriguing.
 ...
PMID:Endomyocardial fibrosis in Egypt: an illustrated review. 915 33


1 2 3 Next >>