Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0038002 (splenomegaly)
 9,873 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Idiopathic myelofibrosis is a myeloproliferative disorder of unknown origin. The bone marrow becomes fibrotic with an associated decrease in hematopoiesis resulting in anemia, bleeding problems, splenomegaly, and other secondary abnormalities. Although idiopathic myelofibrosis is usually diagnosed in middle age, there have been a few reports of the disorder in the pediatric population. This case report documents dental treatment considerations in a 6-year-old female with idiopathic myelofibrosis, severe anemia, and abnormal blood coagulation studies. The patient was successfully treated in a hospital after medical consultation, transfusion of packed red blood cells, and administration of prophylactic antibiotics. Local hemostatic measures following multiple extractions of carious teeth controlled bleeding. No postoperative sequelae occurred.
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PMID:Idiopathic myelofibrosis: dental treatment considerations. 183 Dec 96

A study of health status of Orang Asli population (based on physical examination findings) was conducted in 4 villages in Pos Piah, Sungai Siput Perak, Malaysia. In all 356 individuals between 4 months-72 years old (178 males and 178 females) participated in this study. Poor general health status, physical and mental handicaps were seen in 7.8%, 0.3% and 0.3% of the population, respectively. About one-fifth of the population had dental caries. Splenomegaly, hepatomegaly and hepatosplenomegaly were among the commonest abnormalities with the occurrence rates of 19.8%, 13.7% and 6.7%, respectively, being detected in the population. About one-fifth of the population showed signs suggestive of protein-energy deficiency; whilst less than 5% showed signs indicative of riboflavin, iodine and iron deficiencies. Vitamin A deficiency was the commonest nutritional deficiency identified in this community with almost 38.4% of them showing signs of the deficiency. The commonest skin infection was scabies.
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PMID:Health status of Orang Asli (aborigine) community in Pos Piah, Sungai Siput, Perak, Malaysia. 974 Feb 69

Dental plaque is composed of a biofilm community of microorganisms on teeth that coats the oral cavity, including attaching to the teeth, and provides a protective reservoir for oral microbial pathogens, which are the primary cause of persistent and chronic infectious diseases. Oral streptococci are pioneering organisms that play an important role in biofilm formation on tooth surfaces as well as being primary causative agents of dental caries. The purpose of this study was to clarify the role of the E2f1 gene in susceptibility to dry mouth and bacterial adherence of oral streptococci to tooth surfaces in animal model experiments. A mutation of the E2f1 gene in mice is known to cause enhanced T-lymphocyte proliferation, leading to testicular atrophy, splenomegaly, salivary gland dysplasia, and other systemic and organ-specific autoimmunity. We found a decreased volume of saliva production and protein production rate, along with increased amylase activity, IgA concentration, and mucin 1 concentration in E2F-1(-/-) mice as compared with the control C57BL/6 mice. Further, we quantified the recolonization of oral streptococci in E2F-1(-/-) mice and found that a higher number of some oral streptococci were colonized on the teeth of these mice. In particular, following oral ingestion of 1% sucrose in water, the colonization of Streptococcus mutans increased in comparison with other streptococci. Our results suggest that the E2f1 gene may affect susceptibility for oral biofilm formation by streptococci in humans with dry mouth.
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PMID:Role of gene E2f1 in susceptibility to bacterial adherence of oral streptococci to tooth surfaces in mice. 1520 99

Ethnobotanical knowledge is one of the precious cultural heritage parts of an area that involves the interaction between plants and people and foremost among these are the management of plant diversity by indigenous communities and the traditional use of medicinal plants. An ethnobotanical analysis was conducted in order to document the traditional medicinal uses of plants, particularly medicinally important folklore food phytonims of flora of Samahni valley, Azad Kashmir (Pakistan). In the valley, inhabitants use different taxa of flora in two different ways; herbal medicines and food (vegetable and fruits) medicines. The distinctive geographic position and historic demological background of the area keep folk phytotherapy potential of medicinal herbs hitherto alive, which are used in various forms; as regular herbal medicines prescribed by Hakeems (herbal practitioners) and as food (medicines) recepies suggested by elder people. Among these, some herbs are used as single remedy while others depict better curative effects in synergistic mode against various ailments. Some interesting and uncommon findings are as; Sisymbrium irio is used for treatment of measles, asthma; Solanum miniatum to cure urinary calculi, heart pain, rheumatism, Momordica balsamina leaves as wound healer; Allium sativum bulb juice as anti cancer, contraceptive, blood pressure; Boerhavia diffusa roots as anti jaundice, anemia, edema; Capsicum annuum fruit as omen against evil eye and giant, yellow fever; Corriandrum sativum seeds as diuretic, anti spermatogenesis; Raphanus sativus seeds against syphilis; Solanum miniatum fruit for treatment of enlarged spleen and liver; seed's oil of Pisum sativum as anti spermatogenesis; Bauhinia variegata for skin diseases, ulcers; Malva sylvestris for cough, bladder ulcer; Phoenix sylvestris kernel as anti-aging tonic; Phyllanthus emblica for diuretic, anemia, biliousness; Terminalia chebula to cure chronic ulcers, carious teeth pain, heart problems; Veronica anthelmintica for bandage of broken bones and Withania coagulans is used to treat small pox. Many wild plants are eaten green and raw as salad, or in boiled form of soup as blood and intestine cleansing tonics. Moreover, some plants are spiritually recorded as sacred and used as ritual plant for good omens or against the evil eye and removal of giant. About 95 species of 38 families were recorded to be important part of phyto heritage of folk pharmacopoeia of Samahni valley. Among most frequent used families are Papilionaceae 9.47%, Solanaceae and Poaceae 8.42% each, Cucurbitaceae 7.36% and Brassicaceae and Rosaceae 6.31% each. Among the surveyed families used to treat various diseases, Solanaceae is at first rank with 9.74%, Brassicaceae 8.23% and Cucurbitaceae 7.39% subsequently. Most commonly used families with highest percentage of plants used as food medicines are Solanaceae (11.37%), Brassicaceae (8.38%) and Papilionaceae (7.18%) respectively. Most frequent plant parts used are; roots, leaves, seeds and flowers while popular forms of plants uses are decoction, poultice, infusions, soups and raw form as salad. Importance of ethnobotanical inventory constructed from ethnomedicinal uses and folklore phytonims of flora in perspectives of initiative for future phytochemical and pharmacological research on these taxa to develop and discover of new drugs is present and discussed.
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PMID:An ethnomedicinal survey and documentation of important medicinal folklore food phytonims of flora of Samahni valley, (Azad Kashmir) Pakistan. 1907 Jan 89