Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0037315 (sleep apnea)
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Human Gene/Protein
Calcium/calmodulin-dependent protein kinase ID 12.0
GTPase activating protein and VPS9 domains 1 11.0
AHDC1 10.4
Zinc finger protein 36 10.0
CPAP 9.6
GAPVD1 9.4
TARS2 9.4
ZNF462 9.0
PIBF1 9.0
PRPF40A 8.8
ORP9 8.8
PSG2 8.5
EDR3 8.4
PSG 8.4
Hoxb-13 8.3
CD3EAP 8.3
DLEU7 8.2
hPER2 8.1
CSR 8.0
iduronate-2-sulphatase 7.9
CT90 7.9
CAMK1D 7.6
POGZ 7.6
REM 7.5
MAGEL2 7.4
RAI1 7.4
Nuclear respiratory factor 1 7.3
PLOD3 7.3
STOP 7.1
SIDS 7.1
hSyn 7.1
MEMO 7.1
NEDD1 7.0
PSG1 7.0
C4BPA 6.9
beta1,3-galactosyltransferase 6.9
monocarboxylate transporter 2 6.8
putative nuclear factor 6.7
CSA 6.7
PTGER3 6.6
more...
Disease
pathological emotionality 12.0
Secondary restless legs syndrome 12.0
High altitude periodic breathing 12.0
Subglottic obstruction 12.0
sleep apnea 12.0
Insufficient sleep syndrome 11.4
Primary alveolar hypoventilation 11.0
Sleep drunkenness 11.0
Scalloped tongue 11.0
Central sleep apnea 10.9
Other sleep disorders 10.7
Upper airway resistance syndrome 10.7
Idiopathic Hypersomnia 10.4
disorders of initiating or maintaining sleep 10.4
Epiglottic cyst 10.0
Sleep-related painful erections 9.6
Nonarteritic ischemic optic neuropathy 9.6
Obesity hypoventilation syndrome 9.6
obstructive sleep apnea 9.4
tonsillar hypertrophy 9.2
Floppy eyelid syndrome 9.1
Mandibular retrognathism 9.0
Ondine's curse 8.9
Ondine's curse 8.8
Nasopharyngeal stenosis 8.8
sleep disorders 8.8
Generalized obesity 8.6
Upper airway obstruction 8.6
sleep terrors 8.6
narcolepsy 8.6
parasomnia 8.5
Tracheal obstruction 8.4
restless legs syndrome 8.4
partial monosomy 6q 8.4
Chronic respiratory failure 8.4
Benign neonatal sleep myoclonus 8.4
infantile apnea 8.3
Perennial allergic rhinitis 8.3
sleepwalking 8.1
REM sleep behavior disorder 8.1
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Symptom
Morning headache 10.6
snoring 10.4
Hypersomnolence 9.9
CSR 9.7
Nocturnal angina 9.6
feeling of choking 9.6
Persistent insomnia 9.0
hypersomnia 8.9
abnormal breathing 8.7
Respiratory abnormalities 8.6
eds 8.5
Periodic breathing 8.5
sleepiness 8.4
Neuromuscular weakness 8.3
nocturnal polyuria 8.2
dry throat 8.2
Kussmaul's sign 7.6
Poor sleep 7.4
Lung hyperinflation 7.2
insomnia 7.1
hypercapnia 6.9
Mouth breathing 6.9
bedwetting 6.9
respiratory problem 6.9
Orthostasis 6.8
bradypnea 6.6
situational stress 6.6
hypocapnia 6.5
enuresis 6.4
Nasal symptoms 6.3
stridor 5.9
breath holding 5.8
feeling tired 5.7
nasal congestion 5.4
sighing 5.4
ENT 5.3
cardiovascular impairment 5.2
No pain 5.2
Visual symptoms 5.2
orthopnea 5.1
more...
Drug
Galsulfase 9.4
Aldurazyme 8.8
Aldurazyme 8.8
Idursulfase 8.6
Xyrem 8.1
Tilade 7.9
Armodafinil 7.6
Modafinil 7.5
Equipoise 7.5
Remeron 7.4
Pegvisomant 7.2
Tryptophane 7.0
Anafranil 5.9
Ramelteon 5.6
MINO 5.5
Orlistat 5.4
Atrovent 5.3
Anafranil 5.2
Ketorolac tromethamine 5.2
Tapentadol 5.1
Fluticasone propionate 5.1
PNT 4.9
Diurnal 4.8
NLF 4.7
Mirtazapine 4.7
ENT 4.7
Methyldopa 4.6
Nadolol 4.6
AVC 4.5
Agomelatine 4.4
Nedocromil sodium 4.4
Zonisamide 4.4
Omalizumab 4.3
Pramipexole 4.3
Ipratropium bromide 4.2
Pramipexole 4.2
Liraglutide 4.2
DM1 4.1
Growth hormone 4.0
Theophylline 4.0
more...
Enzyme
iduronate-2-sulfatase 5.6
acetylserotonin O-methyltransferase 5.2
alpha-L-iduronidase 5.0
NAO 4.5
SPT 3.9
ACAT 3.5
PAT 3.2
FFT 3.2
SPT 3.1
O-GlcNAc transferase 3.0
cystathionine gamma-lyase 2.9
p80 2.9
renin 2.8
thromboxane synthase 2.8
phenylethanolamine N-methyltransferase 2.7
cathepsin K 2.7
chymase 2.6
carbonic anhydrase 2.6
DAT 2.4
CAD 2.2
CAD 2.2
caspase-7 2.2
LasR 2.2
IMP dehydrogenase 2.1
CAD 2.1
caspase-7 2.1
BIS 2.1
GAS 2.1
cystathionine beta-synthase 2.0
ADH 1.8
myosin ATPase 1.8
NADPH oxidase 1.4
MAP 1.4
sialyltransferase 1.4
sialyltransferase 1.4
sialyltransferase 1.4
CPT 1.3
NADPH oxidase 1.3
paraoxonase 1.2
CPT 1.2
more...
Compound
DNPD 12.0
Protriptyline 8.4
Phentermine 5.9
CLTC 5.9
Acetazolamide 5.8
CHQ 5.7
Nalmefene 5.6
Sibutramine 5.2
SD 25 5.2
ADMA 5.2
Tamsulosin 5.0
Trazodone 5.0
MIT 4.9
AIR 4.9
MIT 4.9
PNT 4.9
Clonazepam 4.8
Pyridostigmine 4.5
MNE 4.5
Gallamine 4.5
CUE 4.5
Aminophylline 4.5
Phenothiazine 4.4
11-dehydro-thromboxane 4.4
Esmolol 4.4
Prone 4.4
Bisoprolol 4.3
Clomipramine 4.3
SHB 4.3
Zonisamide 4.3
Bepridil 4.3
Nitrazepam 4.3
Tempol 4.2
PAP 4.1
Inactin 4.1
Geigy 4.1
Salmeterol 4.0
Cabergoline 4.0
Mirtazapine 3.9
PAP 3.9
more...