Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0037315 (sleep apnea)
 8,000 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Calcium/calmodulin-dependent protein kinase ID 12.0
GTPase activating protein and VPS9 domains 1 11.0
AHDC1 10.4
Zinc finger protein 36 10.0
CPAP 9.6
TARS2 9.4
GAPVD1 9.4
PIBF1 9.0
ZNF462 9.0
PRPF40A 8.8
ORP9 8.8
PSG2 8.5
EDR3 8.4
PSG 8.4
CD3EAP 8.3
Hoxb-13 8.3
DLEU7 8.2
hPER2 8.1
CSR 8.0
CT90 7.9
iduronate-2-sulphatase 7.9
POGZ 7.6
CAMK1D 7.6
REM 7.5
MAGEL2 7.4
RAI1 7.4
PLOD3 7.3
Nuclear respiratory factor 1 7.3
STOP 7.1
SIDS 7.1
hSyn 7.1
MEMO 7.1
PSG1 7.0
NEDD1 7.0
C4BPA 6.9
beta1,3-galactosyltransferase 6.9
monocarboxylate transporter 2 6.8
putative nuclear factor 6.7
CSA 6.7
PTGER3 6.6
mPR 6.6
MASK 6.5
ASH1L 6.5
EDR1 6.4
MATR3 6.3
pycnodysostosis 6.3
QRFP 6.3
LTF 6.3
MKS 6.3
PIAS4 6.3
acetyl-CoA carboxylase 2 6.2
MsrB3 6.2
AHI1 6.1
OPT 6.1
MPS II 6.1
ms2 6.0
ZBTB7A 6.0
iduronate-2-sulfatase 5.9
ACVR2A 5.9
CLTC 5.9
natriuretic peptide receptor B 5.9
NFATc3 5.8
MAP2K2 5.8
HELIOS 5.8
ARSB 5.8
NKB1 5.7
PLM 5.7
MNK 5.7
PAFR 5.7
ESM-1 5.7
melanoma inhibitory activity 5.6
IDUA 5.6
SNA 5.6
DNA damage-inducible protein 5.6
TNR 5.5
FMR2 5.4
PDHA1 5.4
FIF 5.4
CX3C chemokine receptor 1 5.4
CHAT 5.4
HHH 5.4
prostaglandin E2 receptor 5.4
MD1 5.4
TCS 5.3
EDR2 5.3
ENT 5.3
TASK-2 5.2
P49 5.2
GPR4 5.2
NB-1 5.2
HLA DRB1 5.2
fat mass and obesity associated 5.2
CTSK 5.1
TC1 5.1
NPAS2 5.1
PFL 5.1
SAS 5.0
GABAB2 5.0
GBP 5.0
SGT 5.0
ERAS 5.0
SRO 5.0
alpha-L-iduronidase 5.0
PGDS 4.9
FNDC5 4.9
with Parkinsonism 4.9
MRP-1 4.9
pancreatitis-associated protein 4.9
ADRB3 4.9
orexin 4.9
OSCAR 4.9
FOSB 4.9
COPD 4.9
HRI 4.9
CD40-L 4.8
ACC2 4.8
MPS VI 4.8
EDF 4.8
acetyl-CoA carboxylase 1 4.8
CVT 4.7
endocan 4.7
HTN 4.7
EDN1 4.7
Facioscapulohumeral muscular dystrophy 4.7
TASK-1 4.7
intelectin 4.6
DAN 4.6
DQB1*0501 4.6
mitochondrial glycerol-3-phosphate dehydrogenase 4.6
NIPBL 4.5
AD2 4.5
Galanin-like peptide 4.5
CCTG 4.5
rhodanese 4.5
AT1B 4.5
Acetylcholine receptor 4.4
EPP 4.4
TPM3 4.4
Rubinstein-Taybi syndrome 4.4
vesicular glutamate transporter 2 4.4
aquaporin-3 4.4
SREBF1 4.4
COB 4.4
GDX 4.4
CREBBP 4.4
Megalin 4.3
AIR 4.3
DST 4.3
prostaglandin-endoperoxide synthase 2 4.3
neuroserpin 4.3
UDG 4.3
PWS 4.3
UND 4.3
ANGPTL4 4.2
resistin 4.2
Chymase 4.2
DM1 4.2
MCT2 4.2
AHS 4.2
HO2 4.2
more...
Disease
sleep apnea 12.0
Secondary restless legs syndrome 12.0
High altitude periodic breathing 12.0
Subglottic obstruction 12.0
pathological emotionality 12.0
Insufficient sleep syndrome 11.4
Scalloped tongue 11.0
Sleep drunkenness 11.0
Primary alveolar hypoventilation 11.0
Central sleep apnea 10.9
Upper airway resistance syndrome 10.7
Other sleep disorders 10.7
Idiopathic Hypersomnia 10.4
disorders of initiating or maintaining sleep 10.4
Epiglottic cyst 10.0
Sleep-related painful erections 9.6
Nonarteritic ischemic optic neuropathy 9.6
Obesity hypoventilation syndrome 9.6
obstructive sleep apnea 9.4
tonsillar hypertrophy 9.2
Floppy eyelid syndrome 9.1
Mandibular retrognathism 9.0
Ondine's curse 8.9
Ondine's curse 8.8
Nasopharyngeal stenosis 8.8
sleep disorders 8.8
Generalized obesity 8.6
Upper airway obstruction 8.6
sleep terrors 8.6
narcolepsy 8.6
parasomnia 8.5
Tracheal obstruction 8.4
restless legs syndrome 8.4
partial monosomy 6q 8.4
Chronic respiratory failure 8.4
Benign neonatal sleep myoclonus 8.4
Perennial allergic rhinitis 8.3
infantile apnea 8.3
sleepwalking 8.1
REM sleep behavior disorder 8.1
Multiple symmetrical lipomatosis 8.1
ethanolism 8.1
Cough syncope 8.0
Chronic paroxysmal hemicrania 8.0
Hypothalamic dysfunction 7.9
recurrent tonsillitis 7.8
Recurrent apnea 7.8
Pycnodysostosis 7.7
Severe hypothyroidism 7.7
claustrophobia 7.7
adenoiditis 7.6
Primary insomnia 7.6
Thornwaldt 7.6
cataplexy 7.5
sleep disturbances 7.5
Hypopharynx 7.4
Transient epileptic amnesia 7.4
postpolio syndrome 7.4
sexual dysfunction and infertility 7.4
Cor Pulmonale 7.3
Sleep disturbance 7.2
Diabetic autonomic neuropathy 7.2
Gerhardt 7.1
Kleine-Levin syndrome 7.1
Myhre syndrome 7.1
NARES 7.1
syringobulbia 7.0
Overlap syndrome 7.0
Secondary pulmonary hypertension 7.0
nocturia 7.0
secondary polycythemia 6.9
Mauriac syndrome 6.9
Chronic congestive heart failure 6.9
chronic tonsillitis 6.8
behavior disorder 6.8
OHS 6.7
CSA 6.7
Craniometaphyseal dysplasia 6.7
peritonsillitis 6.7
Negative pressure pulmonary edema 6.7
Nasopharynx 6.6
Nasopharynx 6.6
bruxism 6.6
Tonsil 6.6
hyponasality 6.5
Kluver-Bucy syndrome 6.5
morbid obesity 6.5
sudden infant death syndrome 6.5
Retropharyngeal abscess 6.5
FXTAS 6.4
Sandifer syndrome 6.4
Multiple system atrophy 6.4
cor pulmonale 6.4
endometrial stromal sarcoma 6.4
Vocal cord paralysis 6.4
adjustment reaction 6.4
acromegaly 6.4
TDD 6.4
FIF 6.3
Androgen excess 6.2
MPS II 6.2
muscle contraction headache 6.2
Chronic heart failure 6.2
HFH 6.2
moderate obesity 6.2
Congenital central hypoventilation syndrome 6.2
psychological disease 6.2
CM1 6.1
Lymphoid hyperplasia 6.1
delusions of persecution 6.1
Renal amyloidosis 6.1
obstructive airway disease 6.0
Gallbladder disease 6.0
Patent foramen ovale 6.0
Left ventricular diastolic dysfunction 6.0
orthostatic proteinuria 6.0
hypernasality 6.0
nasopharyngitis 5.9
primary disorders 5.9
vagotonia 5.9
audiogenic epilepsy 5.9
chronic pharyngitis 5.9
laryngospasm 5.8
GH-secreting pituitary adenoma 5.8
depressive psychosis 5.8
mountain sickness 5.8
pediatric disorder 5.8
neurogenic hypertension 5.8
Pure autonomic failure 5.7
secondary hypertension 5.7
Rhinoconjunctivitis 5.7
BHD 5.7
Idiopathic pulmonary arterial hypertension 5.7
Carotid body 5.7
Carotid body 5.7
Carotid body 5.7
erythrocytosis 5.7
oxycephaly 5.7
jetlag 5.7
Uncontrolled hypertension 5.7
supraglottis 5.7
HHH 5.6
Neurogenic pulmonary edema 5.6
blepharochalasis 5.6
cardiovascular risk factor 5.6
pustulosis palmaris et plantaris 5.6
vascular headache 5.6
movement disorder 5.6
overbite 5.6
bradyarrhythmia 5.5
polycythemia 5.5
renin-dependent hypertension 5.5
Chronic insomnia 5.5
CHEST 5.5
Male hypogonadism 5.5
Headache Disorders 5.5
Crouzon syndrome 5.5
hyperventilation syndrome 5.5
brain stem glioma 5.5
MD1 5.5
more...
Symptom
Morning headache 10.6
snoring 10.4
Hypersomnolence 9.9
CSR 9.7
Nocturnal angina 9.6
feeling of choking 9.6
Persistent insomnia 9.0
hypersomnia 8.9
abnormal breathing 8.7
Respiratory abnormalities 8.6
eds 8.5
Periodic breathing 8.5
sleepiness 8.4
Neuromuscular weakness 8.3
nocturnal polyuria 8.2
dry throat 8.2
Kussmaul's sign 7.6
Poor sleep 7.4
Lung hyperinflation 7.2
insomnia 7.1
hypercapnia 6.9
Mouth breathing 6.9
bedwetting 6.9
respiratory problem 6.9
Orthostasis 6.8
bradypnea 6.6
situational stress 6.6
hypocapnia 6.5
enuresis 6.4
Nasal symptoms 6.3
stridor 5.9
breath holding 5.8
feeling tired 5.7
nasal congestion 5.4
sighing 5.4
ENT 5.3
cardiovascular impairment 5.2
No pain 5.2
Visual symptoms 5.2
orthopnea 5.1
hypotonia 5.1
lightheadedness 5.0
myoclonus 4.9
body pain 4.9
leg edema 4.9
collapse 4.7
orofacial pain 4.6
throat irritation 4.5
peri-menopausal 4.5
overweight 4.4
loss of taste 4.4
catarrh 4.4
generalized pain 4.3
Fluctuation 4.3
asterixis 4.3
labored breathing 4.2
drooling 4.2
inanition 4.2
forgetfulness 4.1
blackout 4.1
motor symptom 4.1
fatigue 4.1
chronic cough 4.0
postnasal drip 3.9
heartburn 3.9
male subfertility 3.9
distraction 3.9
sneezing 3.9
personality change 3.8
dyspnea 3.8
dark urine 3.8
lassitude 3.8
halitosis 3.7
cyanosis 3.7
dysarthria 3.7
Sedation 3.6
nasal discharge 3.5
hyperoxia 3.5
joint stiffness 3.5
tachypnea 3.5
productive cough 3.4
decreased appetite 3.4
cerebellar ataxia 3.3
lethargy 3.3
headache 3.2
cough 3.1
rhinorrhea 3.1
sore throat 3.1
Respiratory symptoms 3.1
shortness of breath 3.1
dysesthesia 3.1
wheezing 3.1
Depressive symptoms 3.0
syncopal episodes 3.0
polyuria 3.0
arthralgia 3.0
syncope 3.0
memory loss 2.9
hot flashes 2.9
Decreased activity 2.9
weakness 2.9
skin irritation 2.9
sinus pressure 2.9
Postoperative pain 2.9
clumsiness 2.9
discomfort 2.8
adenitis 2.8
exertional dyspnea 2.8
excessive sweating 2.8
neuralgia 2.8
mental fatigue 2.8
facial pain 2.8
bradykinesia 2.8
ataxia 2.8
respiratory distress 2.7
presyncope 2.7
discomfort 2.7
hypertonia 2.7
rales 2.6
chronic constipation 2.6
anesthesia 2.6
asthenia 2.6
agitation 2.6
thigh pain 2.6
right upper quadrant pain 2.5
partial seizure 2.5
hepatosplenomegaly 2.4
clonus 2.4
hoarseness 2.4
chronic back pain 2.4
anosmia 2.4
seizures 2.3
regurgitation 2.3
dystonia 2.2
Wind 2.2
angina 2.2
incoordination 2.2
clubbing 2.2
muscle cramps 2.1
spasm 2.1
otalgia 2.0
dry skin 2.0
tremor 2.0
Hudson 1.9
spasticity 1.9
analgesia 1.9
tinnitus 1.9
hunger 1.8
hypoproteinemia 1.8
night sweats 1.7
dysuria 1.7
paresthesia 1.7
hot flushes 1.7
pallor 1.7
constipation 1.6
fasciculation 1.6
acute pain 1.6
apathy 1.5
dizziness 1.5
cachexia 1.5
more...
Drug
Galsulfase 9.4
Aldurazyme 8.8
Aldurazyme 8.8
Idursulfase 8.6
Xyrem 8.1
Tilade 7.9
Armodafinil 7.6
Modafinil 7.5
Equipoise 7.5
Remeron 7.4
Pegvisomant 7.2
Tryptophane 7.0
Anafranil 5.9
Ramelteon 5.6
MINO 5.5
Orlistat 5.4
Atrovent 5.3
Anafranil 5.2
Ketorolac tromethamine 5.2
Tapentadol 5.1
Fluticasone propionate 5.1
PNT 4.9
Diurnal 4.8
NLF 4.7
Mirtazapine 4.7
ENT 4.7
Methyldopa 4.6
Nadolol 4.6
AVC 4.5
Agomelatine 4.4
Nedocromil sodium 4.4
Zonisamide 4.4
Omalizumab 4.3
Pramipexole 4.3
Ipratropium bromide 4.2
Pramipexole 4.2
Liraglutide 4.2
DM1 4.1
Growth hormone 4.0
Theophylline 4.0
Android 3.9
Triazolam 3.9
Check 3.8
IPD 3.7
Exenatide 3.6
Rimonabant 3.6
Ritalin 3.6
Growth hormone 3.6
Codeine 3.5
Codeine 3.4
Allergen 3.4
Xanthium 3.3
Atenolol 3.2
Diclofenac sodium 3.2
DEX 3.1
Singular 3.0
Propofol 2.9
Digitalis 2.7
Triad 2.7
Domperidone 2.6
Triad 2.5
Camp 2.5
ROC 2.2
DBS 2.2
Gabapentin 2.2
Gastro 2.1
Cetuximab 2.1
DDAVP 2.1
DDAVP 2.0
TAK 2.0
Clopidogrel 1.9
Spectrum 1.8
Phentolamine 1.8
Horizon 1.7
Serum albumin 1.7
DPA 1.6
CTC 1.6
CCL 1.6
Lovastatin 1.6
Phenytoin 1.6
Spectrum 1.5
Asthma 1.5
caffeine 1.5
Ranitidine 1.3
TAC 1.3
Atropine 1.3
Norplant 1.2
ADR 1.0
Frontal 0.9
Dakar 0.9
nitroglycerin 0.8
MDS 0.8
MAP 0.8
Albumin 0.7
Clonidine 0.7
Nephron 0.6
Angiotensin II 0.6
Fraction 0.6
Nitric Oxide 0.6
Forskolin 0.6
ETA 0.5
CSF 0.5
MOF 0.4
Nephron 0.4
Vitamin A 0.4
Dial 0.4
ADM 0.3
Monit 0.3
Kenyan 0.2
Cardiovasc 0.2
Glucagon 0.1
niacin 0.1
ROS 0.0
Portal -0.1
ABC -0.2
Ethanol -0.3
CTX -0.4
Glutathione -0.4
Posture -0.4
CAM -0.6
vitamin E -0.6
PTH -0.8
Leaf -1.4
ZnO -1.8
IL-2 -1.9
Dermatol -3.2
lysine -3.9
Enzyme
iduronate-2-sulfatase 5.6
acetylserotonin O-methyltransferase 5.2
alpha-L-iduronidase 5.0
NAO 4.5
SPT 3.9
ACAT 3.5
PAT 3.2
FFT 3.2
SPT 3.1
O-GlcNAc transferase 3.0
cystathionine gamma-lyase 2.9
p80 2.9
renin 2.8
thromboxane synthase 2.8
phenylethanolamine N-methyltransferase 2.7
cathepsin K 2.7
chymase 2.6
carbonic anhydrase 2.6
DAT 2.4
CAD 2.2
CAD 2.2
caspase-7 2.2
LasR 2.2
IMP dehydrogenase 2.1
CAD 2.1
caspase-7 2.1
GAS 2.1
BIS 2.1
cystathionine beta-synthase 2.0
ADH 1.8
myosin ATPase 1.8
NADPH oxidase 1.4
MAP 1.4
sialyltransferase 1.4
sialyltransferase 1.4
sialyltransferase 1.4
CPT 1.3
NADPH oxidase 1.3
paraoxonase 1.2
CPT 1.2
glycerol-3-phosphate dehydrogenase 1.2
tryptophan hydroxylase 1.2
glycerol-3-phosphate dehydrogenase 1.1
prolyl hydroxylase 1.1
ACE 1.1
TdT 1.1
cholesterol acyltransferase 0.9
paraoxonase 0.9
heme oxygenase 0.9
choline acetyltransferase 0.9
methylenetetrahydrofolate reductase 0.9
methylenetetrahydrofolate reductase 0.9
chondroitinase 0.9
PDK1 0.8
GSK 0.8
CPT 0.8
CDR 0.7
PKG 0.7
hypoxanthine-guanine phosphoribosyltransferase 0.7
NO synthase 0.6
AST 0.4
phosphodiesterase 0.3
sulfatase 0.3
calcineurin 0.2
HSD 0.2
aspartate aminotransferase 0.1
PDE 0.1
alanine aminotransferase 0.1
acetylcholinesterase -0.0
proteinase K -0.0
succinate dehydrogenase -0.0
cholinesterase -0.1
alpha-glucosidase -0.1
alcohol dehydrogenase -0.2
CD10 -0.3
MIP -0.3
tyrosine hydroxylase -0.3
tissue plasminogen activator -0.5
phosphoinositide 3-kinase -0.6
caspase-1 -0.7
AMPK -0.7
AMP-activated protein kinase -0.7
ribonuclease -0.7
ribonuclease -0.7
caspase-8 -0.8
protein kinase C -0.8
glutathione peroxidase -0.9
superoxide dismutase -0.9
caspase-9 -0.9
xanthine oxidase -1.1
cytochrome oxidase -1.1
gamma-glutamyl transpeptidase -1.2
phospholipase C -1.2
lipase -1.2
creatine kinase -1.2
glutathione reductase -1.3
adenylate cyclase -1.3
lactate dehydrogenase -1.3
protein kinase -1.4
mitogen-activated protein kinase -1.4
phosphatidylinositol 3-kinase -1.5
thrombin -1.5
catalase -1.5
caspase-3 -1.6
ERK -1.6
AMPK -1.6
ATPase -1.7
P-glycoprotein -1.7
beta-lactamase -1.8
PARP -1.8
RNase -2.0
RNase -2.2
collagenase -2.2
luciferase -2.3
lysozyme -2.4
focal adhesion kinase -2.5
glutathione S-transferase -2.5
alkaline phosphatase -2.6
proteasome -2.9
peroxidase -3.0
ACS -4.3
Compound
DNPD 12.0
Protriptyline 8.4
Phentermine 5.9
CLTC 5.9
Acetazolamide 5.8
CHQ 5.7
Nalmefene 5.6
Sibutramine 5.2
SD 25 5.2
ADMA 5.2
Tamsulosin 5.0
Trazodone 5.0
MIT 4.9
AIR 4.9
MIT 4.9
PNT 4.9
Clonazepam 4.8
Pyridostigmine 4.5
MNE 4.5
Gallamine 4.5
CUE 4.5
Aminophylline 4.5
Phenothiazine 4.4
11-dehydro-thromboxane 4.4
Esmolol 4.4
Prone 4.4
Bisoprolol 4.3
Clomipramine 4.3
SHB 4.3
Zonisamide 4.3
Bepridil 4.3
Nitrazepam 4.3
Tempol 4.2
PAP 4.1
Inactin 4.1
Geigy 4.1
Salmeterol 4.0
Cabergoline 4.0
Mirtazapine 3.9
PAP 3.9
PAP 3.9
NCD 3.9
MAD 3.8
Theophylline 3.8
PAP 3.8
Trimethylamine N-oxide 3.8
2-nonenal 3.8
Montelukast 3.8
HMS 3.8
IPD 3.8
Ritalin 3.7
MSL 3.7
Succinylcholine 3.7
Meperidine 3.6
Codeine 3.5
Fenfluramine 3.5
Domperidone 3.5
Desmopressin 3.4
oxygen 3.4
DMD 3.4
PAT 3.4
HAQ 3.3
PAG 3.3
Methylphenidate 3.3
PMS 3.3
Dexmedetomidine 3.2
CO2 3.2
DEX 3.2
Selectin 3.1
Zolpidem 3.1
MAOA 3.1
SVC 3.1
DBT 3.1
8-OHdG 3.1
BIC 3.1
Buspirone 3.0
Flumazenil 3.0
Testosterone 3.0
Quetiapine 3.0
Tanshinone 3.0
Testosterone 3.0
MEP 3.0
VMA 2.9
Desipramine 2.9
DETA 2.9
MEP 2.8
Ondansetron 2.8
Dipyridamole 2.8
Dipyridamole 2.8
Dipyridamole 2.8
Dipyridamole 2.8
Propofol 2.8
CMK 2.8
A 42 2.8
aldosterone 2.7
Baclofen 2.7
Nicardipine 2.7
Hydrochlorothiazide 2.6
PYR 2.6
Homocysteine 2.6
Homocysteine 2.6
DOS 2.6
gamma-hydroxybutyric acid 2.6
Tramadol 2.5
DHPG 2.5
TTA 2.5
DDD 2.5
Sevoflurane 2.5
Carvedilol 2.5
Clindamycin 2.5
DDVP 2.5
Prazosin 2.5
R 2 2.5
Spironolactone 2.5
DAT 2.4
Quinidine 2.4
SO2 2.4
RELA 2.4
Thyroxine 2.4
Chlorpyrifos 2.4
Androgen 2.4
CPA 2.4
6-12 2.3
CPA 2.2
ANS 2.2
HIS 2.2
ANS 2.2
Buprenorphine 2.2
CPA 2.2
DBS 2.2
Evans Blue 2.2
homocysteine 2.1
Optimal 2.1
Vincristine 2.1
Formal 2.1
BNP 2.1
Melatonin 2.1
DBP 2.0
NEM 2.0
Octreotide 2.0
Imipramine 2.0
Imipramine 2.0
Yohimbine 2.0
NPP 2.0
AMD 2.0
Isoflurane 2.0
Hypo 2.0
CPA 2.0
Sildenafil 1.9
DBP 1.9
Coronal 1.8
H2S 1.8
EDS 1.8
Midazolam 1.7
coenzyme Q10 1.7
Digoxin 1.7
Insulin 1.7
Risperidone 1.7
acetamide 1.7
acetamide 1.7
more...