Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0037315 (
sleep apnea
)
8,000
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A series of investigations suggest a specific role for
BCAA
in the regulation of respiration. In vitro incubation studies have shown that BCAAs improve the recovery of muscle force after fatigue. Further investigations revealed that leucine plays a key role in this action and acts in a manner not dependent on its use as an energy substrate. In humans, solutions enriched with
BCAA
have decreased PCO2 and stimulated the ventilatory response to hypercapnia, thereby corresponding to an enhanced ventilatory sensitivity with the administration of
BCAA
. The mechanisms for these actions are unknown. The most viable hypothesis is based on the ability of
BCAA
to decrease the synthesis of serotonin due to altered transport of AAs, including tryptophan, to the brain. Clinical studies have suggested a potency of
BCAA
in the treatment of respiratory dysfunction of preterm infants, as well as of patients with
sleep apnea
related to various disease states. The clinical applications of
BCAA
-enriched mixtures in respiratory diseases are still experimental, and many controversies exist concerning the validity of
BCAA
in clinical practice. Most TPN regimens contain
BCAA
approximating the average intake of
BCAA
in the Western diet. The question therefore remains whether additional
BCAA
supplementation is useful to achieve the suggested metabolic and pharmacological effects. Meticulous future studies are needed to establish the therapeutic value of
BCAA
in the treatment of various respiratory functions.
...
PMID:Branched-chain amino acids and respiration. 142 77
