Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0037315 (sleep apnea)
 8,000 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The objectives of this study were to test the sensitivity of the short form 36 health survey questionnaire (SF 36) to sleep disruption in patients with obstructive sleep apnoea (OSA) and assess its use as an outcome measure for treatment with nasal continuous positive airway pressure (CPAP). Two hundred and twenty-three subjects under investigation for snoring and/or daytime somnolence completed the questionnaire at presentation and again after a six month period. Subjects with OSA requiring treatment scored lower on all dimensions of the SF 36 (P < 0.05) than normative scores for the general population. The largest differences were for vitality (24%) and social functioning (27.9%). After six months of treatment with CPAP there was an improvement in all scores and the score for vitality was no longer significantly different from that of the general population. The SF 36 is sensitive to the effects of sleep disruption in subjects with obstructive sleep apnoea, is a useful outcome measure for treatment with CPAP and its value in other sleep disorders should be assessed.
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PMID:Is the SF 36 sensitive to sleep disruption? A study in subjects with sleep apnoea. 1060 57

Surgical results, economic consequences, and shortterm health of obese patients were evaluated before and after bariatric surgery. Of 35 patients in Mayo Health Plan Arizona eligible for bariatric surgery and scheduled for gastric restriction with Roux-en-Y gastrojejunostomy, 22 (7 men, 15 women) completed pre- and postoperative (6- and 12-mo) short form (SF)-12 Health Surveys. Nineteen patients had open bariatric procedures and 3 had laparoscopic procedures. Comorbid conditions, hospital course, weight loss, and complications were examined. Health care utilization (actual dollars paid by plan) for the preceding year and at 1- and 2-yr follow-up were compared. Major comorbid conditions included diabetes mellitus or impaired fasting glucose, hyperlipidemia, sleep apnea, and hypertension. Mean length of hospital stay was 4.8 d after open procedures and 2 d after laparoscopic procedures. No serious operative or postoperative complications occurred. From a baseline average body mass index (BMI) of 51.9, the 6- and 12-mo BMI averages were 39.6 (23.7% decrease) and 35.3 (32% decrease), respectively. Both physical and mental status improved. From baseline, physical health changed 18 and 21.2 points at 6 and 12 mo, respectively (p < 0.001), and mental health changed 9.3 points at each interval (p =0.003). Each postoperative year, resource utilization decreased (mean= $1300 per patient). Our findings of good surgical outcomes, significant weight loss, improved health status, and potential financial savings in this small sample may help patients, insurers, and self-funded employer groups evaluate the appropriateness of bariatric procedures.
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PMID:Outcomes, health status, and medical resource utilization after bariatric surgery. 1678 80

We utilized well-established and validated quality of life (QoL) measures to test the validity of the Health Utilities Index (HUI) in patients with untreated sleep disorders in a cross-sectional study. We submitted a 66-question survey to 86 patients presenting to the University of Maryland Sleep Disorders Center (68 with sleep apnea, 18 with other sleep disorders). HUI mark 2 (HUI2) and HUI mark 3 (HUI3) were compared with other indices of QoL: medical short form 12 (SF-12), Epworth Sleepiness Scale (ESS), and Functional Outcomes of Sleepiness Questionnaire (FOSQ). The participants of this study were eighty-six patients presenting with untreated sleep disorders to the University Medical Center. There were no interventions. The mean age in our patients was 50.7 +/- 14.2 years with a mean body mass index of 32.9 +/- 7.6. For patients with sleep apnea, the mean respiratory disturbance index was 32.6 +/- 29.1. For all patients, the mean HUI2 score was 0.73 + 0.23, and the mean HUI3 score was 0.6 +/- 0.35 (p = 0.0066 for difference from HUI2). The mean SF-12 physical components (PC) score was 43.6 +/- 12.1, and the mean SF-12 mental components (MC) score was 49.8 identical with 40.1. The mean ESS score was 10.5 + 5.2, and the mean FOSQ score was 16.4 +/- 3.5. Significant bivariate correlations were found between HUI2 and HUI3 as well as between both of these and age, SF-12, SF-12 PC score, ESS, and FOSQ. Stepwise multivariate regression revealed significant independent correlations between HUI2 and age, SF-12 PC and the FOSQ, and between HUI3, SF-12 PC, and the FOSQ. There were no differences in HUI scores between obstructive sleep apnea (OSA) and non-OSA patients: (1) HUI3 scores are lower than HUI2 scores, (2) both HUI2 and HUI3 are correlated with other indices of QoL in sleep patients, and (3) the HUI surveys should be considered in QoL and economic impact studies in patients with sleep disorders.
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PMID:Construct validity for the Health Utilities Index in a sleep center. 1745 30

Sleep apnea-hypopnea syndrome (SAHS) causes serious symptoms and may induce patients' quality of life impairment. The aim of this study was to assess health related quality of life (HRQOL) in Greek patients with various severity SAHS before and after CPAP implementation in comparison with conservative therapy and Greek population normative data. In 180 patients (152 males, 28 females) with SAHS (apnea-hypopnea index, AHI 56 +/- 25.4/h), daytime sleepiness was assessed with the Epworth sleepiness scale (ESS) and measurements of health status were performed using the short form-36 health survey (SF-36) questionnaire and the General Health Questionnaire (GHQ-30). One hundred and thirty five patients underwent CPAP treatment and 45 were assigned to a conservative therapy. After 3 months the measurements were repeated in 105 patients under CPAP treatment and in 15 patients from the conservative group. HRQOL in all patients was lower than Greek normative data before any treatment. In patients with CPAP therapy the ESS decreased (p<0.01) and a significant improvement was observed in SF-36 dimensions (p<0.01). The improvement was more obvious in patients with severe SAHS (p<0.05) than in patients with moderate disease severity. In the majority of patients (60.9%), GHQ-30 score was high and it was negatively related to some SF-36 dimensions and positively to ESS. In patients under conservative therapy, no significant changes were observed in any measure. HRQOL in patients with SAHS at the time of diagnosis was low and reached general population levels in patients treated with CPAP. The improvement was greater in those with severe syndrome.
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PMID:Health related quality of life in Greek patients with sleep apnea-hypopnea syndrome treated with continuous positive airway pressure. 1969 96

Favorable health outcomes at 2 years postbariatric surgery have been reported. With exception of the Swedish Obesity Subjects (SOS) study, these studies have been surgical case series, comparison of surgery types, or surgery patients compared to subjects enrolled in planned nonsurgical intervention. This study measured gastric bypass effectiveness when compared to two separate severely obese groups not participating in designed weight-loss intervention. Three groups of severely obese subjects (N = 1,156, BMI >or= 35 kg/m(2)) were studied: gastric bypass subjects (n = 420), subjects seeking gastric bypass but did not have surgery (n = 415), and population-based subjects not seeking surgery (n = 321). Participants were studied at baseline and 2 years. Quantitative outcome measures as well as prevalence, incidence, and resolution rates of categorical health outcome variables were determined. All quantitative variables (BMI, blood pressure, lipids, diabetes-related variables, resting metabolic rate (RMR), sleep apnea, and health-related quality of life) improved significantly in the gastric bypass group compared with each comparative group (all P < 0.0001, except for diastolic blood pressure and the short form (SF-36) health survey mental component score at P < 0.01). Diabetes, dyslipidemia, and hypertension resolved much more frequently in the gastric bypass group than in the comparative groups (all P < 0.001). In the surgical group, beneficial changes of almost all quantitative variables correlated significantly with the decrease in BMI. We conclude that Roux-en-Y gastric bypass surgery when compared to severely obese groups not enrolled in planned weight-loss intervention was highly effective for weight loss, improved health-related quality of life, and resolution of major obesity-associated complications measured at 2 years.
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PMID:Health outcomes of gastric bypass patients compared to nonsurgical, nonintervened severely obese. 1949 44