Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0037315 (sleep apnea)
 8,000 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It has been reported that a relationship exists between obstructive sleep apnea syndrome (OSAS) and cardiovascular and cerebrovascular diseases. To address this issue, we evaluated whether OSAS is associated with adhesion molecules and inflammatory signs, important indicators of atherosclerosis. Levels of high-sensitivity CRP (hs-CRP) and intercellular adhesion molecule-1 (ICAM-1) were measured in 30 patients with ischemic heart disease, confirmed by coronary arteriography (IHD group). Twenty healthy volunteers without sleep apnea were used as controls (Group N). Sleeping respiratory information was collected using a portable sleep polygraph, together on information about oronasal flow, tracheal sound, chest respiration, and percutaneous oxygen saturation (SpO2) to obtain the apnea-hypopnea index (AHI). In the IHD group, 9 (30%) of the 30 patients showed evidence of OSAS [IHD(AHI> or = 40) group] and 21 did not [IHD(AHI<40) group]. The levels of hs-CRP and ICAM-1 were significantly higher in the IHD group than in the N group (p<0.01). Moreover, the levels of hs-CRP and ICAM-1 were significantly higher in the IHD(AHI > or = 40) group than in the IHD(AHI<40) group (p<0.01). However, after the administration of valsartan, angiotensin II receptor antagonists (ARB) to both IHD groups, the levels of hs-CRP and ICAM-1 decreased significantly in both groups. Moreover, a multivariate analysis revealed that the levels of hs-CRP and ICAM-1 were associated with the severity of sleep apnea. These findings suggest that, in OSAS the levels of hs-CRP and ICAM-1 are decreased and that the administration of ARB decreases the risk of atherosclerosis.
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PMID:Relationship between adhesion molecules with hs-CRP and changes therein after ARB (Valsartan) administration in patients with obstructive sleep apnea syndrome. 1653 6

Revised version of the Japanese Society of Hypertension Guidelines for the Management of Hypertension 2009 (JSH2009) has been delivered in Jan. 2009 (Hypertens Res 32: 3-107, 2009). Followings are the main points of JSH2009 guidelines : (1) CV risk stratification and strategy of hypertension management are revised in consideration with of high-normal BP, metabolic syndrome(risk stratum-2), and CKD(risk stratum-3). (2) Tight control of BP levels < 130/85 mmHg is recommended in general hypertensive patients. More tight control is recommended in patients with DM, CKD, and post MI : BP < 130/80 mmHg. (3) Final target of BP in the elderly is < 140/90 mmHg. However BP should be reduced carefully by setting an intermediate target of < 150/90 mmHg in patients with 75 yrs or over. (4) BP control over 24 hours and usefulness of home BP measurement are stressed. Masked hypertension, morning surge, night-time hypertension, and sleep apnea syndrome are particularly important issues. (5) CCB, ARB, ACE inhibitor, diuretic, and beta-blocker are recommended as initial antihypertensive drugs, combination therapy such as ARB+diuretics or CCB are often necessary to achieve BP target. (6) Tight BP control and specific consideration for choice of drugs such as RA inhibitors are required in hypertension associated with organ damage and hypertension complicated with diabetes, CKD and metabolic syndrome.
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PMID:[Characterisitics of Japanese Guidelines for the Management of Hypertension 2009]. 2211 9