Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0037315 (
sleep apnea
)
8,000
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In excitable cells, small-conductance Ca2+-activated potassium channels (SK channels) are responsible for the slow after-hyperpolarization that often follows an action potential. Three SK channel subunits have been molecularly characterized. The
SK3
gene was targeted by homologous recombination for the insertion of a gene switch that permitted experimental regulation of
SK3
expression while retaining normal
SK3
promoter function. An absence of
SK3
did not present overt phenotypic consequences. However,
SK3
overexpression induced abnormal respiratory responses to hypoxia and compromised parturition. Both conditions were corrected by silencing the gene. The results implicate
SK3
channels as potential therapeutic targets for disorders such as
sleep apnea
or sudden infant death syndrome and for regulating uterine contractions during labor.
...
PMID:Respiration and parturition affected by conditional overexpression of the Ca2+-activated K+ channel subunit, SK3. 1098 76
