Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0037315 (sleep apnea)
 8,000 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A patient had recurrent acute nocturnal pulmonary oedema following an anterior myocardial infarction despite a normal maximal stress electrocardiogram. He had a history of chronic heavy snoring and other symptoms to suggest a diagnosis of obstructive sleep apnoea (OSA) which was supported by an overnight sleep study. The recurrent acute pulmonary oedema was most likely due to a combination of poor left ventricular function and obstructive sleep apnoea.
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PMID:Recurrent acute pulmonary oedema associated with obstructive sleep apnoea. 789 6

The study included 112 patients with acute myocardial infarction and elevated ST segment on ECG depending on the presence of obstructive sleep apnoea syndrome (OSAS). Dynamic analysis clinico-instrumental characteristics after the hospital-based treatment revealed insufficient reduction of ST segment by day 14 of therapy that correlated with severity of the disease estimated from the apnoea/hypopnoea index. Only these patients responded to the treatment by a decrease of the left ventricular ejection fraction as a marker of systolic dysfunction. Apnoea/hypopnoea index over 15 episodes/hr, the history of diabetes mellitus and anterior myocardial infarction were the most significant factors determining the relative risk of OSAS influence on the development of myocardial infarction. The authors emphasize the importance of early diagnostics of OSAS in patients with acute myocardial infarction and the necessity of cardiorespiratory monitoring in addition to hemodynamic one.
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PMID:[Obstructive sleep apnoea syndrome in patients with acute myocardial infarction: the efficacy of treatment and risk factors]. 2351 66