Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0037315 (sleep apnea)
 8,000 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of adenotonsillar enlargement from chronic lymphatic leukaemia leading to severe obstructive sleep apnoea (OSA) is described. Nasal continuous positive airway pressure (nCPAP) therapy was poorly tolerated because even at high pressures (+15 cm H2O) obstructive hypopnoeas persisted. Tonsillectomy resulted in significant improvement, though OSA persisted. nCPAP was reintroduced and at low pressures (+6 cm H2O) was efficacious in alleviating the patient's symptoms. This report highlights the need to consider OSA as a cause of constitutional symptoms in adults with lymphoreticular disease, especially where there is involvement of Waldeyer's ring.
 ...
PMID:Chronic lymphatic leukaemia presenting as severe obstructive sleep apnoea. 944 Nov 19

It was concluded, that airway stenosis in the pharyngeal area is the most frequent cause of sleep apnea syndrome among children. The basis of research were children treated at The Clinic from 1999-2002 and it was stressed that the best way to cure is surgical therapy. Partial tonsillectomy or adenoidectomy is a stable method of dilatation of the airway. Proper treatment depends on correct recognition made by the laryngologist based on interview, clinical examination and pulsoxymetry examination. The less extensive procedures were stressed specially among children because of role of pharyngeal and palatine tonsil, which are the most significant factors of lymphoid tissue of Waldeyer's ring.
 ...
PMID:[Reduction of overgrown lymphatic system among children as a method of restoration of upper airways]. 1531 88