Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0037315 (sleep apnea)
 8,000 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 40-year-old man with severe sleep apnoea syndrome presented significant sinus pauses during a 48 h electrocardiogram Holter recording. Holter analysis showed one sinus pause of 6.4 s duration, and many pauses greater than 3 s. The 48 h Holter reevaluation, after a continuous positive air pressure device was applied, showed no pauses. The electrophysiological study was negative for sick sinus syndrome.
 ...
PMID:Excessive sinus pauses and their elimination in a patient with sleep apnea syndrome. 989 10

The relationship between pacing mode and sleep is not yet known, and therefore polysomnography was used to evaluate the effect. A total of 16 patients (8 men and 8 women; mean age, 72 +/- 9 years) with DDD pacemakers made up the study population. Of these 16 patients, 8 patients had complete AV block and 8 patients had sick sinus syndrome. The recording was done twice in VVI and DDD modes. Between VVI mode and DDD mode, sleep latency time (VVI mode: 38 +/- 25, DDD mode 23 +/- 27 min), frequency of temporary waking (8.3 +/- 6.7, 3.7 +/- 2.9 times), the number of episodes of apnea (59 +/- 84, 36 +/- 55 times, the apnea-hypopnea index (AHI) (15 +/- 18, 10 +/- 13), and efficacy of sleep (72% +/- 10%, 81% +/- 11%) were significantly different. Also, the apnea index improved significantly in DDD mode. There was no significant difference in total sleep time and in total duration of temporary waking between the two groups. From the study results, a reduction in sleep disturbance was achieved when DDD pacing mode was chosen, rather than VVI mode. Furthermore, efficacy of sleep also improved significantly compared with VVI mode. Interestingly, sleep apnea syndrome in four patients with AHI > or = 15 notably ameliorated when DDD mode was chosen; however, the mechanism involved in amelioration is still ambiguous and needs further assessment.
 ...
PMID:Effect of pacing mode on sleep disturbance. 1459 11

The relationship between central sleep apnea (CSA) and bradyarrhythmia remains unclear. We report the case of a 70-year-old man with severe obstructive sleep apnea and bradyarrhythmia due to sick sinus syndrome in whom concomitant CSA was alleviated after pacemaker implantation.
...
PMID:Bradyarrhythmias may induce central sleep apnea in a patient with obstructive sleep apnea. 2474 48

We report on an 83-year-old male with traumatic brain injury after syncope with a fall in the morning. He had a history of seizures, coronary artery disease and paroxysmal atrial fibrillation (AF). No medical cause for seizures and syncope was determined. During rehabilitation, the patient still complained of seizures, and also reported sleepiness and snoring. Sleep apnea diagnostics revealed obstructive sleep apnea (SA) with an apnea-hypopnoea index of 35/h, and sudden onset of tachycardia with variations of heart rate based on paroxysmal atrial fibrillation. Additional tests showed nocturnal AF which spontaneously converted to sinus rhythm mid-morning with an arrest of 5 s (sick sinus syndrome) and seizures. A DDD-pacer was implanted and no further seizures occurred. SA therapy with nasal continuous positive airway pressure was refused by the patient. Our findings suggests that screening for SA may offer the possibility to reveal causes of syncope and may introduce additional therapeutic options as arrhythmia and SA often occur together which in turn might be responsible for trauma due to syncope episodes.
...
PMID:Trauma and syncope-evidence for further sleep study? A case report. 2581 Aug 17