Gene/Protein
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Symptom
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Compound
Pivot Concepts:
Gene/Protein
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Target Concepts:
Gene/Protein
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Query: UMLS:C0037315 (
sleep apnea
)
8,000
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A systematic review of the 19th-century literature related to sleep disorders revealed that patients with obstructive sleep apnea were vividly described in the second half of the century. Also, there were documented observations on the linkage between airway obstructions and noisy snoring, nocturnal insomnia, and excessive somnolence. The coining of the term "pickwickian" to describe an obese somnolent patient was made in 1889 during a clinical presentation of a patient with
sleep apnea
. Respiratory failure in sleep because of "failure of the chest and diaphragmatic movements" was defined as a specific sleep disorder by Silas Weir
Mitchell
in 1890. The two main reasons for overlooking the
sleep apnea syndrome
for so long have been misdiagnosis of patients with
sleep apnea
as having narcolepsy and skepticism regarding the validity of excessive somnolence as a clinical sign.
...
PMID:Nothing new under the moon. Historical accounts of sleep apnea syndrome. 638 98
