Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0037116 (silicosis)
 1,822 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
collagen 132
Sep 113
Mol 71
cytokine 52
tumor necrosis factor 42
TNF 28
TNF-alpha 22
superoxide dismutase 21
Fas 20
CD4 19
IL-6 19
lactate dehydrogenase 18
fibronectin 17
lipopolysaccharide 16
BAL 15
Mal 15
inducible nitric oxide synthase 15
Fas ligand 14
IL-10 14
MRC 14
SMA 13
IL-4 13
catalase 13
p53 12
interleukin-6 12
SMR 12
smooth muscle actin 12
NLRP3 11
IgA 11
rheumatoid factor 11
vimentin 11
caspase-3 11
albumin 11
IL-18 11
HLA 11
GSH 10
IL-1 10
lymphoid 10
glutathione peroxidase 10
E-cadherin 10
CD8 9
myeloperoxidase 9
IL-13 9
interferon-gamma 9
FEV 9
COPD 9
chemokine 8
MAPK 8
ash 8
interferon 8
LDH 7
TGF-beta 7
IFN-gamma 7
Ang II 7
She 7
ANA 6
angiotensin II 6
IFN 6
IL-8 6
p38 6
rat) 6
ECM 6
Pol 6
p21 6
IL-2 6
ATP 6
caspase-8 6
SOD 6
MCP-1 5
IgE 5
cyclooxygenase 5
PBS 5
A-I 5
PDGF 5
macrophage receptor with collagenous structure 5
C-reactive protein 5
IL-23 4
platelet-derived growth factor 4
Bcl-2 4
monocyte chemoattractant protein-1 4
endoplasmic reticulum 4
collagenase 4
chronic renal failure 4
ACE 4
lysozyme 4
ADP 4
ERK 4
ROS 4
B10 4
ras 4
CD95 4
renin 4
transforming growth factor-beta 1 4
FDG 4
p62 4
ESI 4
Nrf2 4
AKT 4
type I collagen 4
thymus 4
RhoA 4
MyD88 4
PI3K 4
NALP3 4
HLA-DR 4
catenin 4
MRI 4
THP 4
IL-17 3
bradykinin 3
mTOR 3
von Willebrand factor 3
nitric oxide synthase 3
GLI 3
Hua 3
p65 3
Gen 3
CRP 3
Cytokine 3
metalloproteinase 3
interleukin-10 3
haptoglobin 3
calcium channel 3
nodal 3
AII 3
thioredoxin 3
topoisomerase I 3
FGF 3
gem 3
interleukin-4 3
transferrin 3
HLA class II 3
mast cell 3
Smad2 3
MMP-9 3
PMS 3
STAT 3
AP-1 3
IkappaBalpha 3
white cell 3
acid phosphatase 3
telomeric 3
vitronectin 3
Smad3 3
FasL 3
Angiotensin-converting enzyme 3
P2X7 3
ceruloplasmin 3
K-ras 3
pyrin 3
transforming growth factor-beta 3
MIP 3
monocyte chemotactic protein 3
ICD 3
NMR 3
SIL 3
tyrosine kinase 3
peroxidase 3
Interferon-gamma 3
EPA 3
matrix metalloproteinase 3
cytochrome 3
TLR4 3
vascular endothelial growth factor 3
L-selectin 3
MIP-1alpha 3
COX-2 3
CO2 3
TOF 2
PARP 2
TGF-beta type II receptor 2
peroxisome proliferator-activated receptor gamma 2
NOD 2
COL1A1 2
ZEB1 2
c-Jun 2
LPS 2
DQB1 2
EPR 2
mitogen-activated protein 2
GLI3 2
ANOVA 2
San 2
HLA-DQB 2
IL-22 2
CD25 2
GPT 2
PUMA 2
poly(ADP-ribose) polymerase 2
Cad 2
5'-nucleotidase 2
Tumor necrosis factor alpha 2
ERK1 2
HOP 2
Y chromosome 2
insulin-like growth factor 2
desmoglein 3 2
cyclin D1 2
TNF receptor 2
ATPase 2
BCL2 2
AKT1 2
HO-1 2
Myeloperoxidase 2
TH1 2
histone 2
EMT 2
IL-1 alpha 2
IL-1 beta 2
hedgehog 2
FGA 2
CD163 2
connexin 2
LC3 2
LTB 2
MMP-2 2
Beclin-1 2
BLT1 2
T cell receptor 2
anonymous 2
thioredoxin reductase 2
glycoprotein 2
JNK 2
CD204 2
BAX 2
group-specific component 2
mucin 2
ID1 2
CD36 2
4-1BB 2
interleukin-1 receptor antagonist 2
LAMP2 2
intercellular adhesion molecule-1 2
IL-5 2
non-Hodgkin's lymphoma 2
alkaline phosphatase 2
ZC3H4 2
plasminogen activator inhibitor-1 2
Smad7 2
extracellular signal-regulated kinase 2
interferon gamma 2
beta-glucuronidase 2
Fc receptor 2
microsomal 2
HECTD1 2
CD28 2
ESR 2
surface antigen 2
Men 2
CD69 2
SP-10 2
ferritin 2
APP 2
TAT1 2
MT-2 2
SP-C 2
purinergic receptor 2
plasminogen 2
HLA-B 2
HECTD1 protein 2
CCL 2
SP-A 2
cytochrome P-450 2
natural killer cell 2
cyclooxygenase-2 2
Cor 2
B18 2
calcitonin 2
PSS 2
GLO1 2
urokinase-type plasminogen activator 2
major histocompatibility complex 2
MCPIP1 2
PLC 2
ICP 2
UTR 2
Tumor necrosis factor 2
DR4 2
esterase 2
Albumin 2
5-lipoxygenase 2
IL-1RA 2
interleukin-2 2
phosphodiesterase 2
cathepsin B 2
protease inhibitor 2
STAT3 2
epsilon-globin 2
uPAR 2
RNase 2
elastin 2
GLI2 2
membrane-bound 2
TGFB1 1
EGF 1
CD86 1
RANTES 1
actin-like 1
Chymase 1
PARK2 1
CD40L 1
desmoglein 1 1
PIK3C3 1
H. influenzae 1
ACT 1
annexin V 1
sex determining region Y 1
ACG 1
matrix metalloproteinase 2 1
CXCL2 1
human leukocyte antigen 1
PPAR 1
zinc finger 1
HLA-DPB1 1
PARP-1 1
DR11 1
vasopressin 1
CAS 1
SCH 1
protein S 1
more...
Disease
silicosis 1822
pneumoconiosis 255
tuberculosis 216
lung cancer 200
asbestosis 153
pulmonary fibrosis 153
cancer 134
lung disease 111
sarcoidosis 82
occupational disease 68
pulmonary tuberculosis 62
PSS 59
emphysema 53
chronic obstructive pulmonary disease 53
occupational lung disease 52
asthma 51
silicotuberculosis 51
idiopathic pulmonary fibrosis 44
rheumatoid arthritis 41
tumor 39
systemic lupus erythematosus 38
interstitial lung disease 37
bronchitis 36
bronchitis 36
chronic bronchitis 33
scleroderma 32
hypertension 28
respiratory disease 28
hypersensitivity pneumonitis 27
Mycobacterium 27
pneumonia 26
mesothelioma 22
diabetes 21
pneumothorax 20
HIV 20
carcinogenesis 20
carcinoma 20
vasculitis 19
respiratory failure 19
glomerulonephritis 18
lymphadenopathy 17
beryllium disease 17
bronchogenic carcinoma 17
autoimmune disease 16
pulmonary hypertension 15
arthritis 14
interstitial pneumonia 14
anthracosis 13
immunodeficiency 12
renal failure 12
AIDS 11
cor pulmonale 11
adenocarcinoma 11
renal disease 11
Raynaud's phenomenon 10
malignant mesothelioma 10
Thorax 10
bronchiectasis 10
depression 10
GSH 10
proteinuria 9
pulmonary alveolar proteinosis 9
lymphoma 9
byssinosis 9
squamous cell carcinoma 9
lupus 9
COPD 9
Thoracic 9
gout 9
bronchiolitis 8
talcosis 8
Moore 8
infectious diseases 8
cirrhosis 8
ash 8
siderosis 8
lymphocytosis 7
West 7
broncholithiasis 7
metastases 7
atherosclerosis 7
cold 7
lung carcinoma 7
anthracosilicosis 7
Wegener's granulomatosis 6
dermatomyositis 6
leukemia 6
pulmonary edema 6
hepatitis 6
amyloidosis 6
carcinomatosis 6
gastric cancer 6
connective tissue disease 6
IgA nephropathy 6
cystic fibrosis 6
heart failure 6
pericarditis 5
chronic disease 5
malnutrition 5
aspergillosis 5
Langerhans cell histiocytosis 5
dysphagia 5
Chronic silicosis 5
chronic renal failure 5
Still 5
lupus 5
osteoporosis 5
Hodgkin's disease 4
anemia 4
fungal infection 4
Caplan's syndrome 4
myocardial ischemia 4
pleurisy 4
adult respiratory distress syndrome 4
cardiovascular disease 4
systemic disease 4
rare disease 4
aggression 4
alcoholism 4
histoplasmosis 4
MAC 3
MIP 3
ICD 3
SLE 3
bronchopulmonary dysplasia 3
bronchopneumonia 3
pleural plaque 3
Fabry 3
thrombocytopenia 3
respiratory infection 3
stroke 3
pulmonary granuloma 3
ischemia 3
neoplastic transformation 3
eosinophilia 3
Poland 3
Chronic necrotizing pulmonary aspergillosis 3
MIN 3
MIN 3
nephritis 3
plaque 3
sepsis 3
influenza 3
Progressive massive fibrosis 3
Cryptococcus neoformans 3
skin disease 3
sepsis 3
lymphadenitis 3
non-Hodgkin's lymphoma 2
dysplasia 2
genetic disorder 2
malaria 2
erythema nodosum 2
pachymeningitis 2
paracoccidioidomycosis 2
prostate cancer 2
purpura 2
substance abuse 2
hemosiderosis 2
coccidioidomycosis 2
Interstitial fibrosis 2
elephantiasis 2
PSS 2
Gaucher disease 2
SEM 2
bone cancer 2
NOD 2
left ventricular failure 2
wasting 2
Castleman's disease 2
aspiration pneumonia 2
sclerodactyly 2
Churg-Strauss syndrome 2
stannosis 2
lipidosis 2
glomerulosclerosis 2
ICP 2
pemphigus 2
right heart failure 2
Legionella 2
farmer's lung 2
disabling disease 2
meningitis 2
PSS 2
Alzheimer's disease 2
blastomycosis 2
tumorigenesis 2
allergic rhinitis 2
gammopathy 2
neuropathy 2
CCL 2
type 2 diabetes 2
cardiomyopathy 2
mixed connective tissue disease 2
lymphatic vessels 2
renal insufficiency 2
tumor progression 2
lymphangioleiomyomatosis 2
dermatitis 2
adenoma 2
collagenosis 2
hyperthyroidism 2
Simple pneumoconiosis 2
dengue 2
Silicotics 2
NAME 2
multiple myeloma 2
EMT 2
Crohn's disease 2
Acute silicosis 2
neuritis 2
rheumatism 2
bacterial infection 2
interstitial nephritis 2
extrapulmonary tuberculosis 2
Granuloma 2
tuberculous pleurisy 2
cholestasis 2
Edwards 1
atypical mycobacterial infection 1
angiosarcoma 1
Thoracic Disease 1
Respiratory morbidity 1
Tumour necrosis 1
pulmonary embolism 1
MacLeod 1
myocardial infarction 1
dementia 1
tularemia 1
hemopericardium 1
folliculitis 1
pulmonary insufficiency 1
bronchospasm 1
TTP 1
chylothorax 1
brain cancer 1
oligohydramnios 1
hepatitis B 1
Kartagener's syndrome 1
psychological stress 1
chronic hepatitis 1
lymphopenia 1
Q fever 1
asthmatic bronchitis 1
lymphoproliferative disorders 1
Raynaud 1
aortic aneurysm 1
Latent tuberculosis 1
hernia 1
collagen disease 1
collagen disease 1
epithelial tumor 1
colorectal cancer 1
chalicosis 1
mycosis fungoides 1
anthrax 1
breast cancer 1
coma 1
arterial embolization 1
bone metastases 1
Syndrome 1
Lupus erythematodes 1
colon cancer 1
EEC 1
neoplastic process 1
parkinsonism 1
antiphospholipid syndrome 1
ATM 1
lymphoepithelioma 1
autoimmune hemolytic anemia 1
conjunctivitis 1
Larynx 1
bacterial pneumonia 1
uremia 1
Mesothelioma 1
Pancoast 1
lymphomatoid granulomatosis 1
tuberculosis; chest 1
tinea pedis 1
suicide 1
secondary hypertension 1
hepatocellular carcinoma 1
thymoma 1
endometriosis 1
Esophageal 1
Chemical pneumonitis 1
SCH 1
esophageal cancer 1
colitis 1
PML 1
pleural disorder 1
rash 1
carcinoma in situ 1
Best 1
Chronic kidney disease (CKD) 1
skin cancer 1
bronchioloalveolar carcinoma 1
Erdheim-Chester disease 1
biliary colic 1
uveitis 1
tracheitis 1
trachoma 1
mediastinitis 1
Giant 1
PCP 1
sarcoma 1
melanoma 1
viral pneumonia 1
immaturity 1
arteriolitis 1
PHA 1
restrictive cardiomyopathy 1
gangrene 1
pemphigoid 1
chemical carcinogenesis 1
melioidosis 1
large cell carcinomas 1
Larynx 1
vascular disease 1
Pemphigus vulgaris 1
more...
Symptom
dyspnea 54
cough 39
hemoptysis 14
respiratory distress 10
chest pain 8
weakness 7
wheezing 7
anesthesia 6
arthralgia 6
pain 6
fatigue 6
exertional dyspnea 5
shortness of breath 5
chronic cough 5
rales 5
Respiratory symptoms 4
headache 4
ataxia 3
productive cough 2
asthenia 2
chest tightness 2
clubbing 2
cyanosis 2
tremor 2
non-productive cough 2
chills 1
hypersomnia 1
myalgia 1
insomnia 1
hypothermia 1
muscle rigidity 1
abdominal discomfort 1
hepatosplenomegaly 1
abnormal breath sounds 1
personality change 1
neuralgia 1
hoarseness 1
night sweats 1
apathy 1
thinning 1
adenitis 1
back pain 1
dizziness 1
sleepiness 1
Chest discomfort 1
ENT 1
anorexia 1
catarrh 1
limb pain 1
hypercapnia 1
dysuria 1
emaciation 1
Spots 1
tachypnea 1
skin irritant 1
collapse 1
Ill 1
abdominal pain 1
hepatomegaly 1
forgetfulness 1
stigma 1
Drug
Silica 110
SiO2 31
Leaf 16
MRC 14
Dermatol 8
TiO2 6
IFN-gamma 6
IL-2 6
ROS 4
lysine 3
ascorbate 3
Tuberculin 3
BCG vaccine 2
Albumin 2
Nephron 2
vitamin E 2
Talc 2
ROC 2
Silica gel 2
CCL 2
ENT 2
NBT 2
Captopril 2
Nephron 2
Terlipressin 1
BLM 1
Cardiovasc 1
ACT 1
NAG 1
Asthma 1
Stenorol 1
Dasatinib 1
Clopidogrel 1
Terlipressin 1
Isoniazid 1
Kaolin 1
Pumice 1
Monit 1
niacin 1
Atractylodes rhizome 1
Flunisolide 1
TMX 1
TAK 1
Gelatin 1
Bosutinib 1
Emodin 1
Award 1
Mutagen 1
ZnO 1
CSF 1
ID2 1
Paraffin 1
Fangji 1
Ferric oxide 1
Emodin 1
Prednisone 1
Ethanol 1
DNase I 1
Dial 1
CTX 1
EPA 1
Enzyme
superoxide dismutase 26
lactate dehydrogenase 18
BAL 15
mitogen-activated protein kinase 14
catalase 13
peroxidase 12
glutathione peroxidase 10
caspase-3 9
ACE 9
ERK 8
lysozyme 5
luciferase 5
beta-galactosidase 5
collagenase 5
arginase 5
caspase-1 5
reverse transcriptase 4
elastase 4
protein kinase C 4
type III procollagen 4
renin 4
ceruloplasmin 3
focal adhesion kinase 3
NADPH oxidase 3
RNase 3
MIP 3
RNase 3
ATPase 3
hexosaminidase 3
caspase-8 3
acid phosphatase 3
alanine aminotransferase 3
NADPH oxidase 3
phosphodiesterase 2
NO synthase 2
topoisomerase 2
urokinase-type plasminogen activator 2
hyaluronidase 2
topoisomerase 2
beta-glucuronidase 2
MMP 2
cathepsin B 2
PARP 2
xanthine oxidase 2
alkaline phosphatase 2
thioredoxin reductase 2
trypsin 2
5'-nucleotidase 2
protein phosphatase 2A 2
neutrophil elastase 2
plasmin 1
ribonuclease 1
lipase 1
collagenase 3 1
protein kinase 1
proteinase-3 1
phospholipase A2 1
APC 1
meprin 1
phospholipase C 1
hyaluronidase 1
glycerol-3-phosphate dehydrogenase 1
ribonuclease 1
matrix metalloproteinase 2 1
lysyl oxidase 1
PDK1 1
phosphatidylinositol 3-kinase 1
cathepsin X 1
peroxiredoxin 1
chitinase 1
glutathione reductase 1
chondroitinase 1
cdc2 1
phosphoglucomutase 1
aspartate aminotransferase 1
adenosine deaminase 1
NOS 1
GK2 1
chondroitinase 1
glutathione S-transferase 1
alpha-galactosidase 1
adenosine deaminase 1
CPT 1
prolidase 1
Hageman factor 1
angiotensin-converting enzyme 2 1
CPT 1
chymase 1
succinate dehydrogenase 1
prolyl hydroxylase 1
ACS 1
glycerol-3-phosphate dehydrogenase 1
MEK 1
thrombin 1
CPT 1
galactosylhydroxylysyl glucosyltransferase 1
MCS 1
PAM 1
CPR 1
tryptase 1
tissue plasminogen activator 1
Compound
silicon 177
Dec 129
oxygen 84
SiO2 62
Clin 57
DNA 50
iron 47
water 31
aluminum 28
TNF 28
Tetrandrine 27
Tetrandrine 27
Tetrandrine 27
Tetrandrine 27
hydrogen 20
calcium 17
BAL 15
titanium 15
chromium 14
nitric oxide 12
phosphate 12
copper 12
tin 12
proline 12
Asbestos 11
cobalt 11
acetate 11
nickel 11
GSH 10
ANCA 10
GSH 10
CO2 10
nitrogen 9
tungsten 8
creatinine 8
cysteine 7
ASA 7
zinc 7
tyrosine 7
sulfate 7
ANA 6
ATP 6
H2O2 6
sodium 6
ANA 6
potassium 5
MDA 5
Hydroxyproline 5
vinyl 5
silver 5
barium 4
Ang II 4
ADP 4
ADP 4
mercury 4
lysine 4
Asp 4
Hematoxylin 4
leucine 4
DMSO 4
BCG 4
THP 4
N-acetylcysteine 4
THP 4
ADP 4
Collagen 4
His 4
alanine 4
benzene 3
2-vinylpyridine 3
pyrene 3
PGE2 3
tryptophan 3
2-vinylpyridine 3
arginine 3
INH 3
manganese 3
tryptophan 3
pyridine 3
salt 3
tryptophan 3
tryptophan 3
MTT 3
2-vinylpyridine 3
glucose 3
Ascorbic acid 3
iodine 2
238A 2
oxalate 2
galactose 2
serine 2
GPT 2
hexose 2
cadmium 2
Angiotensin II 2
aldehyde 2
Dioscin 2
Lead 2
Xenon 2
Cardiol 2
PMA 2
aspartic acid 2
molybdenum 2
PEG 2
Dioscin 2
aspartic acid 2
nitrate 2
TOF 2
DTPA 2
aspartic acid 2
Nodular 2
Proline 2
Rifampicin 2
aldehyde 2
aspartic acid 2
Malondialdehyde 2
PEG 2
fluorine 2
PMA 2
NBT 2
selenium 2
nicotinamide 2
CAT 1
DFO 1
DBA 1
Sodium 1
CPT 1
5-formyltetrahydrofolate 1
kaempferol 1
pyrrolidine 1
ABA 1
Ginsenoside Rg1 1
Bordeaux 1
aflatoxin B1 1
Genistein 1
MEK 1
Azathioprine 1
PPD 1
PPi 1
ornithine 1
oxalic acid 1
Mannan 1
APS 1
Diazepam 1
BCNU 1
hexose 1
phosphorus 1
methyl palmitate 1
formic acid 1
Lea 1
oxalic acid 1
piperidine 1
formic acid 1
NH2 1
oxalic acid 1
Verapamil 1
Nifedipine 1
Tumor Necrosis Factor 1
oxalic acid 1
DEAE 1
Rubiadin 1
Nicorandil 1
CAT 1
DAP 1
prostaglandin E1 1
oxalic acid 1
Janus Green B 1
ornithine 1
cyclohexanol 1
TGR 1
formic acid 1
Rapamycin 1
Tanshinone 1
Prednisone 1
A 71 1
HCO 1
Vinyl chloride 1
vanadium 1
acetonitrile 1
oxalic acid 1
8-OHdG 1
NO3 1
Protect 1
oxalic acid 1
HgCl2 1
XTT 1
NADPH 1
oxalic acid 1
FK506 1
hydrazine 1
MAK 1
Vimentin 1
urea 1
LTD 1
DBA 1
Carrageenan 1
PGD2 1
4-methylpyridine 1
oxalic acid 1
CCl4 1
oxalic acid 1
oxalic acid 1
oxalic acid 1
DBD 1
formic acid 1
Ellagic acid 1
piperazine 1
neopterin 1
CPT 1
MTX 1
oxalic acid 1
formic acid 1
Lac 1
DAP 1
hydroxide 1
formaldehyde 1
formic acid 1
formic acid 1
ornithine 1
Oleanolic acid 1
Carvedilol 1
ACS 1
Methotrexate 1
Emodin 1
valine 1
DBA 1
EDTA 1
threonine 1
glutamine 1
PAS 1
DTA 1
Benin 1
piperidine 1
DPI 1
Ural 1
Vitamin D 1
CTX 1
oxalic acid 1
formaldehyde 1
glutamic acid 1
glutamate 1
UTP 1
SPF 1
isoquinoline 1
EPA 1
Isoproterenol 1
methionine 1
pyrrolidine 1
PGE 1
Baicalin 1
formic acid 1
Tamoxifen 1
hexose 1
Tin 1
NADPH 1
cAMP 1
Phosphatidylinositol 1
Emodin 1
5-HT 1
6-12 1
SO2 1
oxalic acid 1
aldosterone 1
oxalic acid 1
8-hydroxy-5-quinolinesulfonic acid 1
formic acid 1
Pac 1
Dial 1
formic acid 1
Flunisolide 1
Verapamil 1
Dextran 1
ornithine 1
hyaluronic acid 1
prostacyclin 1
ACS 1
BLM 1
Ethambutol 1
Hydroxylysine 1
A 3 1
ethanol 1
COX 1
TTA 1
EDTA 1
CAT 1
superoxide radical 1
Taurine 1
Glibenclamide 1
Lip 1
hexose 1
cyclohexanol 1
oxalic acid 1
PPD 1
ornithine 1
chlorine 1
Haloperidol 1