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Query: UMLS:C0037116 (silicosis)
 1,822 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

CWP is a disease distinct and separate from silicosis. Simple CWP is clearly related to the amount of dust deposited within the lungs. Complicated CWP (PMF) results from dust deposition plus other factors. Immunologic and local cellular factors may contribute to the development of this form of the disease. Studies of lung cell response and function may further elucidate mechanisms and mediators of lung dust reaction. Complicated CWP (PMF) is clearly associated with alterations in ventilatory, mechanical, and vascular function of the lungs. These abnormalities in PMF contribute to the observed premature morbidity and mortality of this disease.
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PMID:Coal workers' pneumoconiosis. 151 52

Findings of the follow-up examination of slate-pencil workers after 16 months are described. The progression of silicosis with this short duration was very rapid with high mortality among those who had conglomerate silicosis at the initial examination. Twenty-three workers had died during this period at a mean age of only 34.7 years, with a mean duration of exposure of 11.9 years. This high mortality is attributed to exposure to high concentrations of silica dust leading to early onset of PMF at a relatively young age. The progression of silicosis within this period was related to the intensity and duration of dust exposure, and also to the severity of silicosis found at the initial examination. Smoking habits had an adverse, though statistically nonsignificant, effect on the evolution of silicosis.
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PMID:Rapid progression of silicosis in slate pencil workers: II. A follow-up study. 299 39

To clarify the management and treatment for the refractory cases of secondary spontaneous pneumothorax (SSP), we analyzed the clinical features in SSP complicating three cases of advanced silicosis, and discussed the available treatment. All three cases were males of age ranging from 60 to 70 years, and had silicosis with massive progressive fibrosis (PMF), classified as type 4 (PR4) according to the ILO guidelines. There was no correlation between the onset of SSP and the smoking habit, or the duration of the occupational exposure to silica. In a total of ten episodes of SSP, a refractory episode occurred in each of the three patients. No surgical treatment was possible because of some complications. Therefore, we administered conservative treatments under mechanical ventilation. The conservative treatments used were tube drainage with suction in each episode and pleurodesis by the combination of minocycline and OK-432 in one case. Approximately one month was the average time required for the air leak cessation. A significant decline in arterial oxygen tension (PaO2) was observed after the treatment of one case, suggesting further respiratory deterioration. These results imply that the more aggressive treatments for refractory SSP should be limited because of the patient status and progression. More information might be required before performing these options safely and effectively.
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PMID:Treatment of secondary spontaneous pneumothorax complicating silicosis and progressive massive fibrosis. 1223 70