Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0037116 (silicosis)
 1,822 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A pilot study was performed to assess the prevalence of hyperreactive bronchial system (HBS) in various occupational lung diseases. 204 patient records were evaluated with the following diagnosis: Allergic rhinitis: (N = 25, 12%), allergic bronchial asthma (N = 70, 34%), toxic asthma (N = 22, 11%), silicosis (N = 12, 6%), asbestosis (N = 15, 7%), farmer's lung (N = 12, 6%), chronic unspecific respiratory syndrome (N = 48, 24%). In each case an inhalative methacholine test (MCHT) was performed. HBS was considered to be present whenever there was a resistance increase of more than 100% of the baseline values. The prevalence of HBS varied between 50% (asbestosis) and 77% (toxic asthma); the average was 68%. Allergic diseases showed a higher prevalence of 71% in comparison to nonallergic diseases with 65%. Patients with silicosis or asbestosis and without additional chronic bronchitis or emphysema demonstrate a "normal" prevalence of HBS of 11%. Age, gender, smoking, alcohol, family history of allergy and repeated bronchitis, the number of eosinophils in the blood. IgE concentration in serum showed no significant association with an increased prevalence of HBS. The coincidence of anamnestically affirmed or denied bronchial hypersensitivity to environmental factors, and the positive or negative result of the MCHT test, was relatively low, being only 43% in case of a "positive" test and 17% in case of a "negative" test.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Pilot study of the prevalence of a hyperreactive bronchial system in various occupationally-induced lung diseases]. 238 88

The numbers of total lymphocyte and lymphocyte subsets in peripheral blood of patients with silicosis and their serum immunoglobulin (Ig) levels were studied to evaluate their immune status. The numbers of total lymphocytes and OKT4+ and OKT8+ cells tended to be decreased and the numbers of OKT3+ cells was significantly decreased (p less than 0.001), but that of OKIa-1+ cells was increased (p less than 0.001) in the patients. In the lymph nodes of the lung hilus, the ratio of OKT4+ cells to total lymphocytes was increased but that of OKT8+ cells to total lymphocytes was decreased. The serum levels of IgG and IgA were elevated in the patients with reduction in the numbers of total lymphocytes and OKT4+ cells in peripheral blood. The serum IgE levels in 17 of 82 patients were above 400 IU/ml. In 8 patients with serum IgE 82 patients were above 400 IU/ml. In 8 patients with serum IgE levels of more than 1,000 IU/ml, the numbers of total lymphocytes and OKT3+ and OKT4+ cells were decreased compared with those in controls. The following suggestions are proposed from the results: Increase and activation of helper T cells may be caused by the presentation of silica dust to macrophages in the lymph nodes, and these cells may then stimulate B cell proliferation and Ig production by B cells, resulting in increase in the serum Ig (IgG, IgA and IgE) level. Reduction in the number of OKT4+ cells helper/inducer T cells) in peripheral blood may be due to migration of helper T cells into the lymph nodes. These immunological events in patients with silicosis are probably due to the adjuvant effect of silica dust.
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PMID:Alterations in lymphocyte subsets and serum immunoglobulin levels in patients with silicosis. 361 59

Humoral and/or cell-mediated immune responses may contribute to the tissue injury in patients with certain types of occupational asthma, hypersensitivity pneumonitis, silicosis, and asbestosis. Numerous diagnostic modalities are available to the clinician investigating the etiology of these disorders. Among the current immunologic techniques discussed in this article are immunoassays for specific anti-IgE antibody, gel diffusion reactions, immunoelectrophoresis, ANA assays, complement studies, and immune complex assays.
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PMID:Immunologic techniques utilized in the diagnosis of occupational lung disease. 643 25

The efficacy of beclomethasone dipropionate (CAS 5534-09-8, BDP, beclomethasone) inhalation therapy over the course of 12 months were evaluated in 42 patients with established chronic silicosis. Their pulmonary functions were monitored every 3 months and volume of sputum production was established daily. Subjects were divided randomly into two groups; 21 patients (BDP group) were treated with BDP (400 micrograms/day) by way of a metered-dose inhaler, while the 21 controls did not receive the BDP inhalation therapy. Although FVC (forced vital capacity), FEV1 (forced expiratory volume in 1 s), MMEF (maximal mean expiratory flow) and arterial blood oxygen tension did not improve significantly, sputum production significantly decreased in the BDP group. The patients who responded most dramatically to the treatment presented with sputum eosinophilia and elevated serum IgE levels prior to therapy. Pulmonary tuberculosis or exacerbation of chronic airway infection was not observed in any of the patients. These results suggest that corticosteroid inhalation therapy is helpful in the management of chronic silicosis, especially in patients with sputum eosinophilia. Positive atopic factors may be related to the pathogenesis of eosinophilic bronchitis, a complication of chronic silicosis.
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PMID:Effect of beclomethasone dipropionate inhalation on eosinophilic bronchitis in patients with silicosis. 945 Jan 66

The study has defined criteria for the concomitant development of tuberculosis as secondary to silicosis. Factorial and discriminant analyses identified the most significant factors of immune homeostasis in silicotuberculosis. The major signs of possible development of tuberculosis in the presence of silicosis are the elevated levels of total IgE and IgG, fibronectin; the cells expressing CD4+ and CD20+ markers; and the decreased concentration of the mucinic antigen 3EG5. The findings were used to construct models of immunity in tuberculosis, silicosis, and silicotuberculosis. The use of a complex of immunological studies promoted the better early diagnosis of silicotuberculosis.
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PMID:[Immunological parameters in the diagnosis of silicotuberculosis]. 1531 28